Suppressive Effect of Dietary Fiber on Elevation of Serum Uric Acid Concentration Induced by Dietary Adenosine and Adenosine-5'-Monophosphate in Rats

抄録

This study was performed to examine the effects of several kinds of dietary fiber (DF) with different physical properties on the elevation of serum uric acid concentration induced by dietary adenosine and adenosine-5'-monophosphate (5'-AMP). Male Wistar strain rats, 4 weeks old, were fed diets with purine compounds-free and adenosine or 5'-AMP (30 mmoll kg diet each) together with or without 50g1 kg diet of DF (cellulose, chitin, chitosan or xanthan gum) for 20 days. The concentrations of uric acid, allantoin and urea nitrogen in serum elevated by additions of purine compounds to the fiber-free diet were significantly suppressed by the test DF as compared with fiber-free. This phenomenon was remarkable in the xanthan gum group. The suppressive effect of chitin and chitosan on the elevation of serum uric acid concentration induced by 5'-AMP was stronger than that induced by adenosine. The present results reveal that the elevation of serum uric acid concentration induced by dietary adenosine and 5'-AMP can be suppressed by DF, and the suppressive effect of DF varied with the type of DF.