2001 年 50 巻 11 号 p. 889-894
Although dietary conjugated linoleic acid (CLA) has been shown to have anti-diabetic activity in Zucker diabetic fatty fa/fa rats, the long-term administration of glycerides rich in CLA (TG-CLA) had no effect on diabetic status in C57BLKS-Leprdb/leprdb(db/db) mice. In the present study, the effect of TG-CLA on blood glucose control in diabetic db/db mice was examined. Mice were fed a diet supplemented with either 1.2% safflower oil (control) or 1.2% TG-CLA. Oral glucose tolerance tests (OGTTs) were performed after 5 and 11 weeks of TG-CLA treatment. The body weight, fat pad weight and amounts of food consumed were lower in the TG-CLA fed mice than in the control. The administration of TG-CLA for 5 and 11 weeks suppressed the blood glucose increase after oral glucose ingestion. Furthermore, the insulin level during OGTTs had increased after 5 weeks of treatment, but it was suppressed after 11 weeks. These results that revealed beneficial effects of TG-CLA on blood glucose control in diabetic db/db mice, in addition to improved insulin sensitivity after a transient increase in insulin secretion, indicate the need for further study in human subjects.