Antimicrobial Activity of Cationic Gemini Surfactant Containing an Oxycarbonyl Group in the Lipophilic Portion against Gram-positive and Gram-negative Microorganisms

Taiga Tatsumi; Yoshitane Imai; Kakuhiro Kawaguchi; Naoko Miyano; Isao Ikeda

doi:10.5650/jos.ess13089

Detergents and Interface Science

Antimicrobial Activity of Cationic Gemini Surfactant Containing an Oxycarbonyl Group in the Lipophilic Portion against Gram-positive and Gram-negative Microorganisms

Taiga Tatsumi, Yoshitane Imai, Kakuhiro Kawaguchi, Naoko Miyano, Isao Ikeda

著者情報

キーワード: antimicrobial activity, biodegradability, cationic surfactant, Gemini surfactant, Gram-positive microorganism, Gram-negative microorganism

ジャーナルフリー

2014 年 63 巻 2 号 p. 137-140

DOI https://doi.org/10.5650/jos.ess13089

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詳細

抄録

We evaluated the antimicrobial activities of a cationic Gemini surfactant, trans-1,4-bis[2-(alkanoyloxy)ethyldimethylammonio]-2-butene dichloride [II-m-2(t-butene)] and its derivatives against Gram-positive and Gram-negative microorganisms. The II-m-2(t-butene) compound was previously shown to have good surface activity and biodegradability. A dodecanoyloxy derivative (m = 12) of II-m-2(t-butene) showed excellent antimicrobial activity against Gram-positive Streptococcus aureus [minimum inhibitory concentration (MIC): 7.8 μg/mL] and Gram-negative Escherichia coli (MIC: 31.2 μg/mL).

責任著者(Corresponding author)

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