Acid-form Sophorolipids Exhibit Minimal Cytotoxicity, Similar to Solvents and Oils Used in Personal Care Products, despite Being Surfactants

Wataru Kumano; Michiaki Araki; Akiko Shimada; Yoriko Kato; Yuka Oda; Yoshihiko Hirata

doi:10.5650/jos.ess23259

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Acid-form Sophorolipids Exhibit Minimal Cytotoxicity, Similar to Solvents and Oils Used in Personal Care Products, despite Being Surfactants

Wataru Kumano, Michiaki Araki, Akiko Shimada, Yoriko Kato, Yuka Oda, Yoshihiko Hirata

著者情報

キーワード: sophorolipids, biosurfactant, Starmerella bombicola, cytotoxicity, irritation, OECD TG439

ジャーナルオープンアクセス早期公開

論文ID: ess23259

DOI https://doi.org/10.5650/jos.ess23259

この記事には本公開記事があります。

The final version of this article is now available: Vol. 73 (2024), No. 9 pp. 1169-1175

詳細

抄録

Surfactants are amphiphilic substances that induce surface tension reduction, washing, and emulsification and are used for various purposes. Recently, biosurfactants manufactured from renewable resources and with high biocompatibility have gained increasing attention. Sophorolipid (SL), a type of biosurfactant derived from Starmerella bombicola, possesses detergency and emulsification properties, making it suitable for household and personal care applications. However, there are limited toxicological data on SLs. In this study, we conducted cytotoxicity and skin-irritation tests using SLs, revealing that cytotoxicity and skin irritation induced by SLs were extremely low (logIC₅₀ = 4.76 mg/L) and equivalent to those of solvents and oils used in personal care products.

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