Artemisia ketone and its related compounds were prepared from alkenylmagnesium chloride and lower carboxylic acids. By the reaction of 2, 2-dimethyl-3-butenoic acid and methallylmagnesium chloride, isoartemisia ketone was obtained in yield of 28%. Isomerization of isoartemisia ketone with p-toluenesulfonic acid gave artemisia ketone in yield of 84%. Similarly, 2, 5, 5, 8-tetramethyl-1, 7-nonadien-4-one was prepared from 2, 2, 5-trimethyl-4-hexenoic acid. (±) -ar-Turmerone was obtained from 3- (p-methylphenyl) butyric acid in the similar manner.
