抄録
The dissolution rates of cholesterol monohydrate as a model of cholesterol gallstone in typical liquid terpenes (ketone, alcohol and ester derivatives) were measured at 37°C by the static disk method. All the terpenes were found to be excellent dissolution agents for cholesterol monohydrate whose dissolution rate was found to depend the number of isoprene residues in the terpene molecules and the rates of terpenes with the same number of isoprene residues decreased in the order of ketone, ester and alcohol.
One of the terpenes was injected directly into the gallbladders of controll mice and found to be an effective dissolution agent for cholesterol gallstones.
