Data are submitted which show that two factors are concerned in the production and cure of the acrodynia-like dermatitis. One is water-soluble factor, viz., vitamin B₆; the other is fatty acid factor similar to linoleic acid.
The evidence suggests that vitamin B₆ is connected in some way with the metabolism of the fatty acids.
I wish to thank Professor U. SUZUKI for his many helpful suggestions concerning this work. I am also indebted to Misses M. Takahashi and H. Sasaki for their generous assistance in preparing the materials and feeding the animals.

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