Biological and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 18,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Sumio Ohtsuki
Faculty of Life Sciences, Kumamoto University
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10,290 registered articles
(updated on September 22, 2020)
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
1.863
2019 Journal Impact Factor (JIF)
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Featured article
Volume 43 (2020) Issue 9 Pages 1293-1300
Current Understanding of the Intestinal Absorption of Nucleobases and Analogs Read more
Editor’s picks

Knowledge of the intestinal absorption of nucleobases and analogs has accumulated, as is generally the case, mainly from studies using non-primate experimental animals. However, the recent identification of sodium-dependent nucleobase transporter 1, which plays a major role in their absorption in such animals, has led to exposing the fact that this important transporter is genetically missing in humans. To help to embark on efforts now needed to elucidate the mechanism of intestinal absorption of nucleobases and analogs in humans, which could be totally different from that in non-primate experimental animals, this article presents a comprehensive review on relevant knowledge and issues.

Volume 43 (2020) Issue 9 Pages 1315-1323
Osthole Improves Cognitive Function of Vascular Dementia Rats: Reducing Aβ Deposition via Inhibition NLRP3 Inflammasome Read more
Editor’s picks

Vascular dementia (VD) is a common neurodegenerative disease, in the progress of which neuroinflammation and beta-amyloid (Aβ) deposition act as vital elements. In this study, lots of Aβ and nod-like receptor protein 3 (NLRP3) inflammasome were found in VD rats’ brains induced by bilateral common carotid artery occlusion. A traditional Chinese medicine-Shechuangzi (osthole) extracted from the fruit of Cnidium monnieri (L.) possesses multiple pharmacological characteristics. This study has been proved the effect of osthole on VD rat evidenced by improving the behavior function, inhibiting the activation of microglia and reducing NLRP3 content, as well as decreasing the Aβ formation.

Volume 43 (2020) Issue 9 Pages 1346-1355
Synergistic Interaction of Ochratoxin A and Acrylamide Toxins in Human Kidney and Liver Cells Read more
Editor’s picks

The toxicity of each ochratoxin A and acrylamide is known but there is uncertainty about the cumulative toxicity of two compounds. In this research, Pyo et al. demonstrated that there is a synergistic relationship between ochratoxin A and acrylamide that raises oxidative stress, reduces antioxidant enzymes and causes apoptosis, exacerbating liver and kidney toxicity. These findings indicate that the risk could be increased further by the food-borne toxicant 's interaction with the toxicant produced during processing.

Volume 43 (2020) Issue 9 Pages 1367-1374
Influence of Crocetin, a Natural Carotenoid Dicarboxylic Acid in Saffron, on L-Type Ca2+ Current, Intracellular Ca2+ Handling and Contraction of Isolated Rat Cardiomyocytes Read more
Editor’s picks

Crocetin is a major bioactive component in saffron (Crocus sativus L.) and it has favorable cardiovascular protective effects. This study investigated the regulative effects of crocetin on L-type Ca2+ current (ICa-L), contractility, and the Ca2+ transients in rat ventricular cardiomyocytes using patch-clamp technique and Ion Optix system. The results indicated that crocetin inhibited ICa-L, intracellular Ca2+ concentration and contractility of cardiomyocytes. Crocetin (600 μg/ml) reduced cell shortening and the crest value of the ephemeral Ca2+ by 28.6 ± 2.31%, 31.87 ± 2.57%, respectively. These findings reveal that crocetin could be a potential calcium blocker for the treatment of cardiovascular disease.

Volume 43 (2020) Issue 9 Pages 1398-1406
Development of a Diagnostic Screening Strategy for Niemann–Pick Diseases Based on Simultaneous Liquid Chromatography-Tandem Mass Spectrometry Analyses of N-Palmitoyl-O-phosphocholine-serine and Sphingosylphosphorylcholine Read more
Editor’s picks

Niemann-Pick diseases are classified into types A/B and C and early definitive diagnosis of them is important for better prognosis of the diseases. The authors developed a novel diagnostic screening strategy for Niemann-Pick diseases using a combination of serum concentrations of N-Palmitoyl-O-phosphocholine-serine and sphingosylphosphocholine based on analyses by liquid chromatography/tandem mass spectrometry. In this study, a rapid method and a validated analysis were developed. The former was useful for screening and the latter were useful for differentiation of Niemann–Pick diseases. This strategy may be useful for screening of Niemann-Pick diseases in clinical practice.

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Announcements from publisher
  • Biol. Pharm. Bull. Vol. 43 No. 4 Current Topics: Recent  Advances  in  Research  on  Particulate  Formulations  such  as  Lipoproteins,  Liposomes,  Extracellular  Vesicles,  and  iPS-Derived  Cells
  • Biol. Pharm. Bull. Vol. 43 No. 3
    Current Topics: Drug Discovery: Recent Progress and the Future

  • Biol. Pharm. Bull. Vol. 43 No. 2
    Current Topics: Challenges in the Control of Environmental Pathogenic Microbes
  • Biol. Pharm. Bull. Vol. 43 No. 1
    Current Topics: Recent Advances in Research on the Mechanisms and Regulation of Allergic Diseases



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