Biological and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 15,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics, which then merged the Journal of Health Science, another former Society’s journal, in 2012. It covers various biological topics in the pharmaceutical and health sciences. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English. The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, scientific communication, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Hidehiko Nakagawa
Graduate School of Pharmaceutical Sciences, Nagoya City University
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11,466 registered articles
(updated on June 23, 2024)
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
2022 Journal Impact Factor (JIF)
Scopus Pubmed
Featured article
Volume 47 (2024) Issue 4 Pages 868-871
Carbon Monoxide Alleviates Post-ischemia–reperfusion Skeletal Muscle Injury and Systemic Inflammation Read more
Editor's pick

Carbon monoxide (CO) exhibits versatile bioactivities; its preventive effect on the progression of ischemia-reperfusion injury in various organs has been reported. The authors developed CO-bound red blood cells (CO-RBC) as a bioinspired CO delivery donor and investigated the therapeutic potential of CO-RBC against ischemia-reperfusion injury in the hind limbs of rats. As a result, CO-RBC alleviated the skeletal muscle injury and systemic inflammation following ischemia-reperfusion in the rat model. The present study significantly contributes to the advancement of CO-based therapeutic strategies for treating skeletal muscle ischemia-reperfusion injury.

Volume 47 (2024) Issue 4 Pages 840-847
Maitake Beta-Glucan Enhances the Therapeutic Effect of Trastuzumab via Antibody-Dependent Cellular Cytotoxicity and Complement-Dependent Cytotoxicity Read more
Editor's pick

HER2 overexpression is observed in 15-20% of breast cancers and is associated with an aggressive phenotype and poor prognosis. Trastuzumab is the primary treatment for HER2-positive breast cancers. However, trastuzumab resistance is often observed, highlighting the need for novel therapeutic approaches to improve clinical benefits. This study showed that Maitake beta-glucan MD-Fraction enhanced the therapeutic effect of trastuzumab in HER2-positive xenograft models. MD-Fraction enhances trastuzumab-induced antibody-dependent cellular cytotoxicity, complement-dependent cellular cytotoxicity, and complement-dependent cytotoxicity. These findings suggest that the combination of trastuzumab and MD-Fraction could be beneficial for the treatment of HER2-positive breast cancer.

Volume 47 (2024) Issue 4 Pages 764-770
Monocarboxylate Transporters 1 and 2 Are Responsible for L-Lactate Uptake in Differentiated Human Neuroblastoma SH-SY5Y Cells Read more
Editor's pick

Lactate transport via monocarboxylate transporters (MCTs) in the central nervous system is crucial for the memory formation. The present study aimed to identify transporters that contribute to lactate transport in differentiated human neuroblastoma SH-SY5Y cells, which are used as a model for neurons. Kinetic analysis suggested that lactate transport was biphasic. Selective inhibitors for MCT1 and MCT2 significantly inhibited lactate transport. Therefore, the authors found that MCT1 and MCT2 are major contributors to lactate transport in differentiated SH-SY5Y cells. These results lead to a better understanding of the involvement of MCTs in the memory formation and central nervous system disease.

Volume 47 (2024) Issue 4 Pages 791-795
Interactions between Age-Related Type 2 Diabetes and the Small Intestine Read more
Editor's pick

This study examined the pathological mechanisms in the small intestine and the aging effects using a mouse model of type 2 diabetes (KK-Ay/TaJcl) aged 10  and 50 weeks. The results showed that Advanced glycation end products (AGEs) and mast cell expression increased, whereas diamine oxidase (DAO) decreased in the small intestine with age. Increased TNF-α and histamine levels occurred in plasma and the small intestine. The cell adhesion molecules ZO-1 and claudin-1 expression decreased in the small intestine. These findings may explain the pathological mechanisms and complications of type 2 diabetes.

Volume 47 (2024) Issue 4 Pages 809-817
Angiotensin II Is Involved in MLKL Activation During the Development of Heart Failure Following Myocardial Infarction in Rats Read more
Editor's pick

[Highlighted Paper selected by Editor-in-Chief]
Angiotensin II is known to be an important factor in the development of chronic heart failure. The authors showed that angiotensin II is involved in the induction of necroptosis, a type of programmed necrosis-like cell death, during the development of heart failure in rats following myocardial infarction and in cultured cells. This finding suggests a new mechanism of action for angiotensin II inhibitors and is expected to contribute to a novel therapeutic strategy for heart failure by targeting necroptosis.

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Announcements from publisher
  • Announcement of Academic Journals’ Awards Biological and Pharmaceutical Bulletin (BPB)
  • Biol. Pharm. Bull. Vol. 47 No. 5
    Current Topics: Pharmaceutical Research for Viral Infectious Diseases
  • Biol. Pharm. Bull. Vol. 46 No. 9
    Current Topics: Recent Advances in Understanding Nervous System Responses against Physical, Chemical, and Biological Stresses