Biological and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 18,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Sumio Ohtsuki
Faculty of Life Sciences, Kumamoto University
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10,382 registered articles
(updated on December 01, 2020)
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
2019 Journal Impact Factor (JIF)
Scopus Pubmed
Featured article
Volume 43 (2020) Issue 12 Pages 1815-1822
Pharmaceutical Technology Innovation Strategy Based on the Function of Blood Transport Proteins as DDS Carriers for the Treatment of Intractable Disorders and Cancer Read more
Editor’s picks

Hemoglobin and albumin are biogenic molecules with unique and interesting inherent characteristics. The utilization of their inherent characteristics makes it possible to develop innovative pharmaceutical and biomedical preparations for the treatment and diagnosis of intractable disorders that can be a groundbreaking strategy to resolve and improve several clinical problems. In this review, author introduces the pharmaceutical technology, strategies, and therapeutic application of drug delivery system carriers that have been designed on the basis of the structure and function of hemoglobin and albumin.

Volume 43 (2020) Issue 12 Pages 1884-1892
JTE-952 Suppresses Bone Destruction in Collagen-Induced Arthritis in Mice by Inhibiting Colony Stimulating Factor 1 Receptor Read more
Editor’s picks

Bone damage in rheumatoid arthritis (RA) occurs in an early stage after disease onset, and osteoclasts play a pivotal role in its progression and subsequent irreversible structural destruction of joints. Colony stimulating factor 1 receptor (CSF1R) is a receptor protein tyrosine kinase specifically expressed in monocytic-lineage cells such as macrophages and osteoclasts. Authors investigated the effect of JTE-952, a novel CSF1R tyrosine kinase inhibitor, on osteoclast formation in vitro and on bone destruction in an animal model of RA. In this article, Uesato et al. suggested that JTE-952 effectively prevents the progression of the structural destruction of joints, a major unmet clinical need for RA.

Volume 43 (2020) Issue 12 Pages 1899-1905
Anti-metastatic Effects of Baicalein by Targeting STAT3 Activity in Breast Cancer Cells Read more
Editor’s picks

Signal transducer and activator of transcription 3 (STAT3) plays an essential role in a pro-carcinogenic inflammatory microenvironment, both at the initiation of malignant transformation and during cancer progression. In this study, Hayakawa and colleagues found that baicalein, a flavone isolated from the roots of Scutelleria baicalensis, inhibited STAT3 transcriptional activity and its phosphorylation, and further exhibited anti-proliferative effects in breast cancer cells. Moreover, baicalein suppressed the production of IL-6 and the metastatic potential of breast cancer cells both in vitro and in vivo. This study suggests baicalein as an attractive phytochemical compound for reducing metastatic potential of breast cancer cells by regulating STAT3 activity.

Volume 43 (2020) Issue 12 Pages 1911-1916
The Carboxyl-Terminal Penta-Peptide Repeats of Major Royal Jelly Protein 3 Enhance Cell Proliferation Read more
Editor’s picks

Royal jelly (RJ) is a well-known functional foodstuff derived from honey bees and contains various functional substances.  In this report, the authors focused on major royal jelly protein 3 (MRJP3), which is one of the major protein components in RJ, and found that MRJP3 possessed cell proliferation activities in cultured cell lines.  The activities were identified in the tandem penta-peptide repeats (TPRs) consisting of Q-N-x-N-[K/R] at its C-terminus of MRJP3.  As the cell proliferation activities remained even after treatment of TRPs with trypsin, it is plausible that the penta-peptide is the minimal functional unit.

Volume 43 (2020) Issue 12 Pages 1924-1930
Silver Nanoparticles Induce DNA Hypomethylation through Proteasome-Mediated Degradation of DNA Methyltransferase 1 Read more
Editor’s picks

In this study, Maki et al., evaluated changes in DNA methylation induced by silver nanoparticles and attempted to elucidate the induction mechanism. The results showed that silver nanoparticles with diameter of 10 nm (nAg10) induces DNA hypomethylation accompanied with a decrease in the level of Dnmt1 in A549 alveolar epithelial cells. We The authors also revealed that nAg10 promotes the degradation of Dnmt1 by the proteasome system. Collectively, these results suggest that nAg10 induced DNA hypomethylation through a proteasome-mediated degradation of Dnmt1. This paper provides basic evidence for the effect of silver nanoparticles on DNA methylation.

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Announcements from publisher
  • Biol. Pharm. Bull. Vol. 43 No. 4 Current Topics: Recent  Advances  in  Research  on  Particulate  Formulations  such  as  Lipoproteins,  Liposomes,  Extracellular  Vesicles,  and  iPS-Derived  Cells
  • Biol. Pharm. Bull. Vol. 43 No. 3
    Current Topics: Drug Discovery: Recent Progress and the Future

  • Biol. Pharm. Bull. Vol. 43 No. 2
    Current Topics: Challenges in the Control of Environmental Pathogenic Microbes
  • Biol. Pharm. Bull. Vol. 43 No. 1
    Current Topics: Recent Advances in Research on the Mechanisms and Regulation of Allergic Diseases