Biological and Pharmaceutical Bulletin

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Volume 41 (2018) Issue 9 Pages 1456-1462

Effects of Supplementary Seleno-L-methionine on Atopic Dermatitis-Like Skin Lesions in Mice

Tomohiro Arakawa, Takahiro Sugiyama, Haruka Matsuura, Tomofumi Okuno, Hirofumi Ogino, Fumitoshi Sakazaki, Hitoshi Ueno

Effects of selenium supplementation on atopic dermatitis (AD) were investigated by administering seleno-L-methionine (SeMet) using a mouse model of AD caused by repeated application of 2,4,6-trinitrochlorobenzene (TNCB). BALB/c mice were sensitized with TNCB to the abdomen on day −7; then, TNCB was applied repeatedly to each ear three times a week from days 0 to 23. SeMet was orally administered to the mice from days 0 to 23. The efficacy of SeMet on AD was assessed by measuring ear thickness, histologic evaluation, serum total immunoglobulin (Ig) E levels, and expression of interleukin (IL)-4 in the ear and superficial parotid lymph node. Ear thickness was remarkably increased by repeated application of TNCB, and SeMet significantly suppressed ear thickness in BALB/c mice. SeMet inhibited epidermal hyperplasia and dense infiltration of inflammatory cells. The number of TNCB-induced mast cells was significantly decreased by SeMet. Serum total IgE levels that increased by the repeated application of TNCB were significantly suppressed by SeMet. Repeated application of TNCB induced expression of IL-4, a T-helper (Th) 2 cytokine, in the ear and superficial parotid lymph node of BALB/c mice and its expression was significantly inhibited by SeMet. These results demonstrated that SeMet supplementation suppresses AD-like skin lesions in BALB/c mice and inhibits the expression of total IgE and IL-4.

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Seleno-L-methionine (SeMet) is a major form of selenium compounds in foods. The article by Arakawa et al. demonstrated that ear thickness was increased by repeated application of 2,4,6-trinitrochlorobenzene (TNCB) to the ear, and SeMet significantly suppressed ear thickness in mice. SeMet inhibited epidermal hyperplasia and dense infiltration of inflammatory cells. Serum total immunoglobulin (Ig) E levels were suppressed by SeMet. Interleukin (IL) 4 expression in the ear and superficial parotid lymph node was inhibited by SeMet. These results demonstrated that SeMet suppresses atopic dermatitis-like skin lesions and inhibits the expression of total IgE and IL-4.

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2018 Volume 41 Issue 9

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