Biological and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 16,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Sumio Ohtsuki
Faculty of Life Sciences, Kumamoto University
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10,814 registered articles
(updated on May 29, 2022)
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
2020 Journal Impact Factor (JIF)
Scopus Pubmed
Featured article
Volume 45 (2022) Issue 5 Pages 576-582
The Effects of Sacran, a Sulfated Polysaccharide, on Gut Microbiota Using Chronic Kidney Disease Model Rats Read more
Editor's pick

Sacran, a type of new sulfated polysaccharide, is a biomaterial with excellent water solubility and safety, and is expected to be used in pharmaceuticals of the future. In the present study, sacran suppressed oxidative stress and inhibited the progression of chronic kidney disease (CKD). Sacran also had a multifaceted effect on the progression of CKD by altering the mix of intestinal microflora as a prebiotic in addition to the above effects. Thus, sacran is expected to have an effective nephroprotective effect especially when oxidative stress initially appears at the early stage of renal failure.

Volume 45 (2022) Issue 5 Pages 614-624
PI3K/AKT1 Signaling Pathway Mediates Sinomenine-Induced Hepatocellular Carcinoma Cells Apoptosis: An in Vitro and in Vivo Study Read more
Editor's pick

Hepatocellular carcinoma is one of the most frequent cancers. Sinomenine (SIN) is a compound derived from Sinomenium acutum. Authors’ investigations have found that SIN suppressed SK-Hep-1 cells’ proliferation, enhanced the collapse of potential of the mitochondrial membrane, triggered cell apoptosis, down-regulated PI3K p85α, AKT1, BCL-2, Pro-Caspase 9, Pro-Caspase 3 expressions, and up-regulated Cleaved Caspase 9 and Cleaved Caspase 3 expressions. In addition, insulin-like growth factor-1 could reverse the high apoptosis of SK-Hep-1 cells induced by SIN. Therefore, authors revealed that inhibition of PI3K/AKT1 signaling cascade by SIN induced hepatocellular carcinoma cells apoptosis.

Volume 45 (2022) Issue 5 Pages 635-642
Chronic Volume Overload Caused by Abdominal Aorto-Venocaval Shunt Provides Arrhythmogenic Substrates in the Rat Atrium Read more
Editor's pick

Atrial enlargement often provides arrhythmogenic substrates, leading to the induction of atrial fibrillation. The authors examined the anatomical, molecular biological, and electrophysiological characteristics of remodeled atria in rats with 8- and 12-week of aorto-venocaval shunt (AVS). It is noteworthy that marked electrophysiological changes were detected only in the AVS-12W rat despite obvious increments in atrial and ventricular tissue weights and altered gene expression in the AVS-8W rat, which suggests that the electrical remodeling observed in the atrium is preceded by structural remodeling after AVS surgery. These findings provide important information on experimental evidence regarding the timing of generation of arrhythmogenic substrate in the atria.

Volume 45 (2022) Issue 5 Pages 649-658
Transforming Growth Factor Beta Promotes the Expansion of Cancer Stem Cells via S1PR3 by Ligand-Independent Notch Activation Read more
Editor's pick

Breast cancer are originated from cancer stem cells (CSCs), which contribute to drug resistance and recurrence. The authors examined the effects of transforming growth factor beta (TGFβ) signaling on proliferation of breast CSCs. TGFβ induced the proliferation of CSCs via phosphorylation of sphingosine kinase 1 (SphK1) via a Smad-independent manner and subsequent production of sphingosine-1-phosphate (S1P). Moreover, Notch pathway was involved in the S1P response via S1P receptor 3. These results suggest that TGFβ-SphK1-S1P-Notch signaling pathway is a novel therapeutic target in breast cancer.

Volume 45 (2022) Issue 5 Pages 664-667
Ca2+ Signaling and Proliferation via Ca2+-Sensing Receptors in Human Hepatic Stellate LX-2 Cells Read more
Editor's pick

Hepatic stellate cells (HSCs) are a key player in the pathogenesis of hepatic fibrosis including cirrhosis. The development of hepatic fibrosis is associated with enhanced calcium signaling in HSCs. However, the regulatory mechanism of calcium signaling in HSCs is largely unknown. In addition, there is no specific therapeutic drug for hepatic fibrosis currently. This report reveals that calcium-sensing receptors are expressed in human HSCs and function in the regulation of calcium signaling and cell proliferation. These findings help to elucidate the molecular mechanism of hepatic fibrosis and develop a potential therapeutic target for hepatic fibrosis.

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Announcements from publisher
  • Biol. Pharm. Bull. Vol. 44 No. 11
    Current Topics: Recent Advances in the Understanding of Nuclear Receptors- and Drug-Metabolizing Enzymes-Mediated Inter-Individual Differences
  • Biol. Pharm. Bull. Vol. 44 No. 10
    Current Topics: Recent Advances in Research on Vascular Permeability to Establish Novel Therapeutic and Drug Delivery Strategies for Intractable Diseases