Biological and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 18,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Sumio Ohtsuki
Faculty of Life Sciences, Kumamoto University
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10,214 registered articles
(updated on June 02, 2020)
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
2018 Journal Impact Factor (JIF)
Scopus Pubmed
Featured article
Volume 43 (2020) Issue 6 Pages 932-937
Ziyuglycoside II Inhibits Rotavirus Induced Diarrhea Possibly via TLR4/NF-κB Pathways Read more
Editor’s picks

In the present study, Ziyuglycoside II inhibits rotavirus (RV) induced diarrhea via toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) signaling pathway. Ziyuglycoside II inhibited the proliferation of MA104 cells infected with RV via suppressing RV duplication. The combination of Ziyuglycoside II and Ribavirin protected against RV-induced diarrhea through regulating TLR4/NF-κB signaling pathway. Moreover, the combined treatment suppressed the level of pro-inflammation cytokines and overexpressed anti-inflammation cytokine. Moreover, the combined therapy improved the lesion changes and inhibited the cell apoptosis in vivo. Thus Ziyuglycoside II may function as protective role in RV-induced diarrhea.

Volume 43 (2020) Issue 6 Pages 959-967
Characterization and Immunological Activities of Polysaccharides from Polygonatum sibiricum Read more
Editor’s picks

Polygonatum sibiricum first appeared in ancient Chinese medicine books around 1000 years ago and is used to tonify the spleen and nourish the lungs. The authors present here a kind of natural polysaccharides (PSP) extracted from Polygonatum sibiricum were purified, characterized and assayed both in vitro and in vivo for its immunomodulatory activity and mechanism. It is of interest to note that PSP not only regulated the immune function of normal mice, but participated in the protection against immunosuppression in cyclophosphamide-treated mice, highlighting its potential as an immunostimulant.

Volume 43 (2020) Issue 6 Pages 968-975
Potential Mechanisms Underlying the Hepatic–Protective Effects of Danshensu on Iron Overload Mice Read more
Editor’s picks

Danshensu (3-(3,4-dihydroxyphenyl)-(2R)-lactic acid) is one of the water-soluble active ingredients of Salvia miltiorrhizae, a traditional Chinese medicine for the treatment of cardiovascular diseases. This study investigated the protective effects of Danshensu on the acute liver injury induced by iron overload in mice. The results indicated that the underlying mechanisms at least partly involve anti-oxidation, anti-inflammation, anti-apoptosis, and decreasing hepatic iron deposition possibly through down-regulating the expression of iron uptake related proteins, such as DMT1, TfR, and L-type Ca2+ CP α1C. Therefore, they conclude Danshensu could be a promising prophylactic or therapeutic agent for iron overload diseases.

Volume 43 (2020) Issue 6 Pages 1007-1015
Detection of Abacavir-Induced Structural Alterations in Human Leukocyte Antigen-B*57 : 01 Using Phage Display Read more
Editor’s picks

The interaction of human leukocyte antigen (HLA) with specific drugs induces structural alteration in HLA and delayed-type hypersensitivity reactions, which cause severe cutaneous toxicity. Shirayanagi et al. selected specific phage antibodies able to recognize HLA-B*57:01 and evaluated structural alterations in HLA-B*57:01 complexes induced by abacavir. The affinity of selected phage antibodies increased because of structural alterations in HLA-B*57:01 following exposure to abacavir, indicating that specific phage antibodies can identify drug-mediated structural changes in HLA complexes. These results suggest that phage display technology is a useful method for detecting structural changes in HLA complexes.

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Announcements from publisher
  • Biol. Pharm. Bull. Vol. 43 No. 4 Current Topics: Recent  Advances  in  Research  on  Particulate  Formulations  such  as  Lipoproteins,  Liposomes,  Extracellular  Vesicles,  and  iPS-Derived  Cells
  • Biol. Pharm. Bull. Vol. 43 No. 3
    Current Topics: Drug Discovery: Recent Progress and the Future

  • Biol. Pharm. Bull. Vol. 43 No. 2
    Current Topics: Challenges in the Control of Environmental Pathogenic Microbes
  • Biol. Pharm. Bull. Vol. 43 No. 1
    Current Topics: Recent Advances in Research on the Mechanisms and Regulation of Allergic Diseases