Biological and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 15,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Sumio Ohtsuki
Faculty of Life Sciences, Kumamoto University
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11,025 registered articles
(updated on January 27, 2023)
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
2021 Journal Impact Factor (JIF)
Scopus Pubmed
Featured article
Volume 46 (2023) Issue 1 Pages 1-11
Chemical Activation of Piezo1 Alters Biomechanical Behaviors toward Relaxation of Cultured Airway Smooth Muscle Cells Read more
Editor's pick

Inspired by the well-known phenomenon of stretch-induced airway dilation in normal lung and the emerging stretch-responsive Piezo1 channels, the authors in this study demonstrated that chemical activation of Piezo1 channels by agonist YODA1 dramatically reduced the contractility of cultured ASMCs in terms of cells stiffness, traction force, migration, and expression of molecules associated with cell mechanics. These findings indicate that chemical activation of Piezo1 can indeed modulate biomechanical behaviors of ASMCs towards relaxation. And this novel regulatory mechanism as alternative to the conventional b2-adrenergic receptor for relaxation of ASMCs may provide a potentially new target for bronchodilation in asthma therapy.

Volume 46 (2023) Issue 1 Pages 19-25
Impact of Drugs and Patient Characteristics on Life Expectancy during the Induction Phase of Dialysis Read more
Editor's pick

Various factors affect the prognosis of dialysis patients. Analysis of the drugs used and clinical and demographic characteristics of the patient at the time of dialysis initiation is a useful means of estimating prognosis. The authors investigated the drugs used by dialysis patients during the induction phase of dialysis and performed a detailed analysis of variables predictive of prognosis. As a result, antihypertensives, hemoglobin, and age at start of dialysis were found to have significant effects on dialysis duration. It was posited that antihypertensives prolong dialysis duration, thereby improving life expectancy. These findings may be used to improve drug adherence in dialysis patients and guide physicians in their treatment.

Volume 46 (2023) Issue 1 Pages 86-94
Altered Pharmacological Efficacy of Phenobarbital with the Treatment of 7,8-Dihydroxyflavone, an Agonist of Tropomyosin Receptor Kinase B, in Rats Read more
Editor's pick

Tropomyosin receptor kinase B (TrkB) may be a key modulator of the pharmacological effects of barbiturates. Suzuki, et al., used a TrkB agonist 7,8-dihydroxyflavone (DHF) in the animal study for phenobarbital-induced general anesthesia, demonstrating that rats receiving the DHF pretreatment readily fell into anesthesia in a shorter time than those without the pretreatment. They then showed that DHF promotes the TrkB to be phosphorylated and that the protein expression of the potassium chloride transporter KCC2 was consequently suppressed. It was thus revealed that DHF potentiates the pharmacological effects of phenobarbital as it causes the functional activation of the TrkB.

Volume 46 (2023) Issue 1 Pages 102-110
Specific Cellular Effects of Low Bortezomib Concentrations on Purified Cultures of Schwann Cells, Satellite Glial Cells, Macrophages, and Dorsal Root Ganglion Neurons Read more
Editor's pick

Bortezomib is widely used in treating multiple myeloma, but causes serious adverse effects, such as peripheral neuropathy, leading to discontinuation of Bortezomib treatment. To explore the mechanism, the authors, unlike previous reports, applied relatively low concentrations of bortezomib at clinical concentration, to primary cultured Schwann cells, satellite glial cells, macrophages, and dorsal root ganglion neurons. The results showed that bortezomib caused Schwann cell dedifferentiation, increased GFAP levels in satellite glial cells without inducing inflammatory responses, and decreased ion channel expression in dorsal root ganglion neurons. This may explain the mechanism of bortezomib-induced peripheral neuropathy.

Volume 46 (2023) Issue 1 Pages 111-122
Transforming Growth Factor-β1 and Bone Morphogenetic Protein-2 Inhibit Differentiation into Mature Ependymal Multiciliated Cells Read more
Editor's pick

Ependymal cilia on the ventricular surface play pivotal roles in cerebrospinal fluid flow. Authors newly constructed the polarized primary culture system of ependymal multiciliated cells (MCCs) from undifferentiated glial cells using a permeable filter in which they retained ciliary movement. Fetal bovine serum (FBS) on the ventricular side of culture inhibited the differentiation with ciliary movement. Transforming growth factor-b1 (TGF-b1) and Bone morphogenetic protein (BMP)-2 mimic the inhibitory action of FBS. The inhibition on the differentiation by FBS was recovered by the TGF-b1 and BMP-2 inhibitors in combination. Taken together, TGF-b1 and BMP-2 are found to be major inhibitors in the differentiation of ependymal MCCs.

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  • Biol. Pharm. Bull. Vol. 45 No. 10
    Current Topics: Rotational Catalysis and Diverse Functions of Proton-Pumping ATPases