Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 16,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Sumio Ohtsuki
Faculty of Life Sciences, Kumamoto University
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27,886 registered articles
(updated on January 24, 2022)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
2020 Journal Impact Factor (JIF)
Scopus Pubmed
Featured article
Volume 70 (2022) Issue 1 Pages 1-9
Elucidation of Complex Dynamic Intermolecular Interactions in Membranes Read more
Editor’s picks

A combination of biophysical techniques revealed various complex molecular interactions in membranes.  Antimicrobial peptides form toroidal pores with surrounding lipids, followed by translocation into the cytosol.  Amyloid β-protein recognizes clusters of monosialoganglioside GM1 on neuronal membranes, forming toxic amyloid fibrils containing 2-residue-shifted antiparallel β-sheets.  The coiled–coil labeling method enables a quantitative analysis of membrane protein associations.  The introduction of a GXXXG motif drives the formation of an otherwise unfavorable parallel dimer of a model transmembrane helix.

Volume 70 (2022) Issue 1 Pages 10-11
Foreword Read more
Editor’s picks

These current topics introduce the latest research on the liquid chromatographic techniques utilized in food analysis. These liquid chromatographic techniques are based on various detection methods including UV detection, fluorescence detection, electrochemical detection and MS. These methods incorporate innovations that go beyond simple chromatography, such as derivatization to improve detectability of analyte, effective separation from matrices by fluorous chemistry, multidimensional chromatography to separate a wide range of polar compounds, and the use of methylated reference for the determination without calibration curves using single reference liquid chromatography. The contents of the topics would provide useful suggestions to improve analysis of important ingredients in food samples.

Volume 70 (2022) Issue 1 Pages 57-65
Stabilizers for Osmium Isotopes in Microwave-Irradiated Acid Digestion and Inductively Coupled Plasma Mass Spectrometry Analysis Read more
Editor’s picks

The overestimation of osmium is often observed in spike recovery test by ICP-MS. This is because osmium formed the highly volatile osmium tetroxide in an oxidation reaction when microwave digestion. The authors investigated the methods to stabilize osmium by using four compounds, thiourea, ascorbic acid, sodium sulfite, and potassium metabisulfite, that could reduce the overestimation of osmium isotopes. All compounds were useful for stabilizing osmium and showed good spike recovery results. The influence of adding compounds against other elements defined by Q3D was also investigated.

Volume 70 (2022) Issue 1 Pages 74-81
Gray-box Soft Sensor for Water Content Monitoring in Fluidized Bed Granulation Read more
Editor’s picks

The authors developed accurate and descriptive three types of gray-box models to enhance process understanding and precise quality control in fluidized bed granulation. These gray-box models were constructed by integrating the heat and mass balance model (white-box model) and locally weighted partial least squares regression (LW-PLSR) model (black-box model). Their applicability was demonstrated using real operating data on a commercial scale with two formulations. Furthermore, the authors proposed the assessment method based on Hotelling’s T2 and Q residual for gray-box models using LW-PLSR, which contributes decision support to select gray-box or white-box model.

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Announcements from publisher
  • Chem. Pharm. Bull. Vol. 70 No. 1
    Current Topics: Liquid Chromatographic Techniques in Food Sciences
  • Chem. Pharm. Bull. Vol. 69 No. 10
    Current Topics: Analytical Chemistry in Biology and Medicine