Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 17,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Sumio Ohtsuki
Faculty of Life Sciences, Kumamoto University



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27,776 registered articles
(updated on June 15, 2021)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
1.416
2019 Journal Impact Factor (JIF)
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Featured article
Volume 69 (2021) Issue 6 Pages 503-515
Target Protein-Oriented Isolations for Bioactive Natural Products Read more
Editor’s picks

Structure and bioactivities of natural products are often beyond human knowledge and imagination. In this article, the author developed original screening methods based on protein binding activity. Protein beads method and protein plate method were described. Protein beads method led to the discovery of neural stem cell differentiation activators which inhibited Hes1 dimer formation as a new mechanism. The author also developed protein plate method for protein-protein interaction inhibitors to find new cancer drug candidates. Because protein binding ability is tightly related to bioactivity, protein-based natural products isolation is a powerful means to find new candidate medicines.

Volume 69 (2021) Issue 6 Pages 516-525
Development of Catalytic Reactions for Precise Control of Chemoselectivity Read more
Editor’s picks

A cooperative catalyst comprising a soft Lewis acid/hard Brønsted base enabled chemoselective activation of a hydroxyl group over an amino group. The present chemoselective catalysis could be applicable for a variety of amino alcohols, including pharmaceuticals, without requiring a tedious protection-deprotection process. Chemoselective enolization and subsequent α-functionalization of carboxylic acid derivatives were also achieved by a redox active catalyst through the radical process, providing unnatural α-amino/hydroxy acid derivatives bearing a complex carbon framework and a diverse set of functionalities. The present chemoselective catalysis described herein offers new opportunities to expand the chemical space for innovative drug discovery research.

Volume 69 (2021) Issue 6 Pages 526-528
Fluorescent-Oxaboroles: Synthesis and Optical Property by Sugar Recognition Read more
Editor’s picks

The optical property of fluorescent unit-conjugated aliphatic oxaboroles has been investigated in this featured article. The authors described the synthesis of fluorescent-oxaboroles by originally developed methods and the optical behavior of the boroles with various sugars. The oxaboroles provide good fluorescence quantum yields and selective recognition toward D-ribose and D-ribose-containing molecules. The molecular recognition induced significant fluorescence quenching. The authors also revealed the positive correlation between the LUMO energy of the oxaborole and the relative fluorescence intensity. The property of the boroles showed the possibility of the boron-based NAD sensor probe.

Volume 69 (2021) Issue 6 Pages 537-547
A New Bitterness Evaluation Index Obtained Using the Taste Sensor for 48 Active Pharmaceutical Ingredients of Pediatric Medicines Read more
Editor’s picks

Quantitative evaluation for bitterness of pediatric medicine is essential for adherence.  The authors proposed criteria, change in concentration-dependent potential (CCDP), dose-response slope of the sensor outputs of active pharmaceutical ingredients measured by an artificial taste sensor, which is new and useful bitterness evaluation index for 48 pediatric medicines from the recent edition of the WHO model list of essential medicines for children (7th ed., 2019). CCDP by individual basic bitterness sensor well correlated to various physicochemical factors related hydrophilicity and hydrophobicity. Therefore, CCDP proved to be useful as a bitterness evaluation index of APIs in pediatric medicines.

Volume 69 (2021) Issue 6 Pages 564-572
Discoveries and Syntheses of Highly Potent Antimalarial Troponoids Read more
Editor’s picks

Novel 25 derivatives of puberulic acid were synthesized by utilizing the authors’ total synthetic route. According to previous structure-activity relationships information, they focused on the carboxylic acid moiety in puberulic acid and converted it into the corresponding esters, amides and ketones. Antimalarial evaluations in vitro and in vivo of these derivatives were carried out and revealed detailed SAR information. It was clarified that several ester and ketone derivatives conserve strong antimalarial activity similar to that of puberulic acid without any obvious toxicity in oral dose of 15 mg/kg.

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Announcements from publisher
  • Announcement of Academic Journals’ Awards Chemical and Pharmaceutical Bulletin (CPB)
    https://cpb.pharm.or.jp/award/award.pdf
  • Chem. Pharm. Bull. Vol. 69 No. 1
    Current Topics: Pharmaceutical Research for Quality Evaluation and Characterization of Foods and Natural Products
  • Chem. Pharm. Bull. Vol. 68 No. 12
    Current Topics: New Era of Polyphenol Research
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