Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 18,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Ken-ichi Hosoya
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama



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27,328 registered articles
(updated on March 22, 2019)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
1.258
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Featured article
Volume 67 (2019) Issue 3 Pages 271-276
A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules Read more
Editor’s picks

Wet granulation is one of the fundamental unit operations for manufacturing pharmaceutical solid dosage forms including tablets. This study investigated in detail the states of water incorporated in wet granules composed of different fillers. The key instrument to evaluate the state of water was a low-field benchtop 1H-NMR time-domain NMR (TD-NMR). This study successfully concluded that the state of water significantly affected the wet granulation process and the characteristics of the resultant granules. The findings can offer valuable knowledge on wet granulation process from the viewpoint of molecular mobility of water.




Volume 67 (2019) Issue 3 Pages 258-264
A Retrospective Analysis of the Effect of Tigecycline on Coagulation Function Read more
Editor’s picks

A number of clinical trials demonstrated that tigecycline was effective and well tolerated in the treatment of patients with various bacterial infections, but few literatures had shown the coagulopathy induced by tigecycline. The retrospective analysis in this paper to assess the impact of tigecycline on coagulation parameters in 50 patients showed that the plasma fibrinogen (FIB) level decreased during treatment, which was statistically significant (P < 0.001). The mean values of activated partial thromboplastin time (aPTT) and prothrombin time (PT) were significantly increased, respectively. It is necessary for practitioners routinely monitor coagulation level in at-rick patient populations treated with tigecycline.




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  • Chem. Pharm. Bull. Vol. 67 No. 3
    Current Topics: Drug Discovery: Recent Progress and the Future




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