Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 18,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Ken-ichi Hosoya
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama



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27,295 registered articles
(updated on January 22, 2019)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
1.258
2017 IMPACT FACTOR
JOURNALS PEER REVIEWED FREE ACCESS FULL-TEXT HTML ADVANCE PUBLICATION
Featured article
Volume 67 (2019) Issue 1 Pages 64-70
Synthetic Studies of Isoschizogamine: Alternative Preparation of the Key Intermediate Read more
Editor’s picks

Isoschizogamine is a member of the schizozygane family of indole alkaloids. Its highly fused hexacyclic structure containing an aminal adjacent to a quaternary stereocenter makes it a challenging synthetic target. While the authors reported the total synthesis of (–)-isoschizogamine in 2012, this paper describes an alternative preparation of their pivotal synthetic intermediate. The synthesis features a stereoselective construction of a quaternary carbon by the Claisen-Johnson rearrangement and a stereoselective rhodium-mediated 1,4-addition of arylboronic acid. The reliability of this synthetic route enables a sufficient supply of the intermediate for the total synthesis of isoschizogamine.




Volume 67 (2019) Issue 1 Pages 59-63
Assessment of Repeatability in Supercritical Fluid Chromatography with Electrochemical Detection Based on the ISO 11843 Part 7 Read more
Editor’s picks

Assessment of repeatability in supercritical fluid chromatography with electrochemical detection (SFC-ECD) system is necessary to construct an SFC-ECD as a quantitative method with satisfactory precision.   This article is the first report that a method for the assessment of repeatability in SFC-ECD has been proposed by means of the ISO 11843 part 7 which can theoretically provide detection limits and standard deviation (SD) through the stochastic properties of baseline noise without repetitive measurements of real samples.   The present method is practically useful, and both experimental time and chemicals can be saved to estimate the repeatability in SFC-ECD.   




Volume 67 (2019) Issue 1 Pages 47-58
Discovery of Novel 7-[(1R,5S)-1-Amino-5-fluoro-3-azabicyclo[3.3.0]octan-3-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropane]-8-(methoxy or methyl)quinolones Read more
Editor’s picks

A series of 8-methoxy or 8-methylquinolones bearing novel 3-aminooctahydrocyclopenta[c]pyrrole derivatives at the C-7 position was synthesized, and the pharmacological, physicochemical, and toxicological properties of the individual compounds were evaluated. Novel 7-[(1R,5S)-1-amino-5-fluoro-3-azabicyclo[3.3.0]octan-3-yl]-6-fluoro-8-methylquinolone 7 exhibited potent and better activity than LVFX and MFLX against streptococci, staphylococci, enterococci, E. coli, A. baumannii, and anaerobes. Compound 7 also demonstrated favorable pharmacokinetic and pharmacodynamic properties and an acceptably safe toxicological profile. Consequently, compound 7 was selected as a clinical candidate for further evaluation as a new-generation, broad-spectrum quinolone antibiotic. Compound 7 is expected to become an option for antibacterial therapy against multidrug-resistant A. baumannii.




Volume 67 (2019) Issue 1 Pages 32-40
Repurposing of Approved Cardiovascular Drugs against Ischemic Cerebrovascular Disease by Disease–Disease Associated Network-Assisted Prediction Read more
Editor’s picks

Polygenetic and complex diseases are great burden and challenge of human, such as ischemic cerebrovascular disease (ICD) and cardiovascular diseases (CVD). Drug repositioning, is one important approach to reexamine the new indications of marketed drugs, especially drugs with multi-targets. Based on the interplay among diseases, genes (targets) and drugs, new method can be applied to dissect the association information. A multi-database, in silico target identification, gene function enrichment, and network pharmacology analysis integrated methods were proposed to investigate the approved CVD drugs repurposing for ICD. It provides promising alternative to inferring novel disease indications for existing safe and effective drugs.




Volume 67 (2019) Issue 1 Pages 1-17
Development of New Synthetic Methods Using Oxiranyl Anions and Application in the Syntheses of Polycyclic Ether Marine Natural Products Read more
Editor’s picks

Oxiranyl anions are very unstable and uncommon nucleophiles while epoxies are widely used as electrophiles in organic chemistry. A sulfonyl-stabilized oxiranyl anion reacts efficiently with a triflate to afford an alkylated product in high yield. The high synthetic potential of the oxiranyl anion chemistry was demonstrated by the total synthesis of gymnocin-A, a cytotoxic polycyclic ether marine natural product produced by the red tide organism Karenia mikimotoi.




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