Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 18,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Ken-ichi Hosoya
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama

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27,407 registered articles
(updated on July 17, 2019)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Featured article
Volume 67 (2019) Issue 7 Pages 693-698
Transition in Longgu Surface Associated with Decoction Process of Keishikaryukotsuboreito Read more
Editor’s picks

Longgu is a fossil crude drug used in Kampo prescriptions, but its role in the decoction is still unclear. The authors hypothesized that it adsorbs foreign organic compounds into its superficial pores, and aimed to reveal it indirectly by 1H magic angle spinning NMR spectroscopic analysis, thermogravimetric analysis and nitrogen adsorption isotherm. These analyses revealed that longgu was macroporous material, and it adsorbed organic compounds during the decoction process. Although further study is required, the authors suggest that the significance of longgu is in adjusting the component profiles in Kampo decoctions as an adsorbent.

Volume 67 (2019) Issue 7 Pages 620-631
Chemical Studies on Bioactive Natural Products Directed toward Development of Novel Antiinfective and Anticancer Medicines Read more
Editor’s picks

Natural products are potential sources of lead compounds, especially intractable chemotherapeutic targets that require molecules with three-dimensional diversity rather than flatter “drug-like” molecules. This review article highlights the author’s efforts toward establishing synthetic routes to natural anti-tuberculosis and anti-tumor products, including structure−activity relationship studies. The synthetic targets, caprazamycin C, intervenolin, and leucinostatin A, exhibit striking biologic properties, such as antibacterial activity toward highly resistant strains of tuberculosis and interference with growth signals from stromal cells to tumor cells.

Volume 67 (2019) Issue 7 Pages 609-619
Discovery of Nuclear Receptor Ligands and Elucidation of Their Mechanisms of Action Read more
Editor’s picks

The author developed a series of vitamin D analogues which act as agonist, partial agonist, or antagonist for vitamin D receptor (VDR). The author examined the structures of the ligand-binding domain (LBD) of VDR complexed with the analogues by the X-ray crystal structural analysis, and small-angle X-ray scattering analysis combined with molecular dynamics simulation. All states of the VDR-LBD, which include agonist-, partial agonist- and antagonist-binding structures and apo-state structure, were clarified. Thus the author elucidated the mechanisms of VDR agonism, partial agonism, and antagonism based on structural changes (differences) in VDR-LBD induced by ligand binding.

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Journal news & Announcements
  • Chem. Pharm. Bull. Vol. 67 No. 7
    Current Topics: Recent Research in Bioactive Natural Products from Traditional Medicinal Plants

  • Chem. Pharm. Bull. Vol. 67 No. 4
    Current Topics: Recent Progress in Biophysical Research of Biological Membrane Systems

  • Chem. Pharm. Bull. Vol. 67 No. 3
    Current Topics: Drug Discovery: Recent Progress and the Future