Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 15,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Sumio Ohtsuki
Faculty of Life Sciences, Kumamoto University
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28,256 registered articles
(updated on May 26, 2024)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
2022 Journal Impact Factor (JIF)
Scopus Pubmed
Featured article
Volume 72 (2024) Issue 4 Pages 393-398
Discovery of a Novel Lidocaine Metabolite by Human Liver Microsome and Identification of Microbial Species Which Produces the Same Metabolite Read more
Editor's pick

Preparation of drug metabolites at the milligram scale is essential for determining their structure and toxicity. However, their preparation using recombinant proteins and human liver microsomes is often difficult because of technical and ethical issues. In this study, authors found that bacteria isolated from “natto” can produce an unknown lidocaine metabolite, which is produced by human liver microsome. Then, they prepared a fraction containing the metabolite through mass cultivation of Bacillus subtilis, then identified the metabolite by NMR. Authors demonstrated that food microorganisms can be a tool to prepare drug metabolites at a low cost and without ethical issues.

Volume 72 (2024) Issue 4 Pages 349-359
Development of Methodologies toward the Unified Synthesis of Ellagitannins Read more
Editor's pick

This review describes the development of methodologies toward the unified synthesis of ellagitannins, a class of polyphenols with divergent structures, as reported by the Yamada group at Kwansei Gakuin University during 2017–2023. Efficient methods for constructing 3,6-O-(aR)- and 4,6-O-(aR)-hexahydroxydiphenoyl-bridged glucose moieties, in addition to various C–O digallate structures, are disclosed. The total synthesis of corilagin, mallotusinin, neostrictinin, and rugosin C is also achieved via application of the established methods, which are expected to enable increase of the number of ellagitannins that can be chemically synthesized.

Volume 72 (2024) Issue 4 Pages 360-364
Unexpected Formation of 11(9→7)-abeo-Steroid Skeleton in Synthetic Studies toward Batrachotoxin Read more
Editor's pick

The authors previously disclosed two synthetic routes to batrachotoxin, a potent cardio- and neurotoxic steroid isolated from certain species of frogs.  The manuscript reports the attempted assembly of its ABCD-ring by an alternative strategy.  While Pd/Ni-promoted Weix coupling linked the AB-ring and D-ring fragments, samarium(II) iodide-mediated pinacol coupling did not cyclize the C-ring.  Instead, samarium(II) iodide promoted a 1,4-addition of the α-alkoxy radical intermediate to produce the unusual 11(9→7)-abeo-steroid skeleton.  Thus, this study demonstrates the convergent assembly of the skeleton of the natural product matsutakone in 11 steps from commercially available 2-allyl-3-hydroxycyclopent-2-en-1-one.

Volume 72 (2024) Issue 4 Pages 374-380
A Method for the Tensile Strength Prediction of Tablets with Differing Powder Plasticities Read more
Editor's pick

This study provided the prediction equation of tablet strength of binary powder mixture with different plastic deformability. The five materials from the general pharmaceutical powders were selected based on their plastic deformability, and their compression properties were evaluated by the Heckel analysis and the compression energy analysis. The plastic deformability of the powder mixture was evaluated to estimate the tablet strength using the compression properties of powder mixture. This finding indicated that the ideal mass fraction of plastic powders to form tablets with sufficient tablet strength could be predicted from the compression properties of single material.

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