Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 18,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Sumio Ohtsuki
Faculty of Life Sciences, Kumamoto University



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27,621 registered articles
(updated on August 06, 2020)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
1.416
2019 Journal Impact Factor (JIF)
JOURNALS PEER REVIEWED FREE ACCESS FULL-TEXT HTML ADVANCE PUBLICATION
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Featured article
Volume 68 (2020) Issue 8 Pages 683-693
Development of Transition-Metal-Catalysed Cross-Coupling Reactions through Ammonium C–N Bond Cleavage Read more
Editor’s picks

Amine groups occur widely in many naturally abundant chemicals and artificial functional molecules. Efficient C–N bond conversion methods suitable for late-stage functionalization would greatly expand their synthetic utility. However, transformation of C–N bond is generally difficult, due to the high stability. Ammonium salt is an ideal pre-activation form for amine, since it can be obtained quantitatively from amine via simple protocol. In this review, synthetic transformations through ammonium C–N bond cleavage developed by the author’s group are summarised, describing a new trend for utilization of amine in organic synthesis.

Volume 68 (2020) Issue 8 Pages 753-761
Screening, Synthesis, and Evaluation of Novel Isoflavone Derivatives as Inhibitors of Human Golgi β-Galactosidase Read more
Editor’s picks

The authors previously reported novel β-galactosidase activity in the human Golgi apparatus and predicted the precursor GLB1 isoform 1 as the enzyme responsible for this activity. GLB1 isoform 1 is involved in lysosomal storage diseases and widely used as a biomarker of cellular senescence. Inhibitor-derived chemical probes may serve as powerful tools for identifying the enzyme. In this study, the authors screened inhibitors from two compound libraries. One of the obtained inhibitors showed increased inhibitory activity following redesigning using molecular docking simulations. This inhibitor may be useful for developing chemical probes to identify the enzyme discovered by the authors.

Volume 68 (2020) Issue 8 Pages 762-765
Simple and Rapid Evaluation of the Unique Manuka Factor in Manuka Honey Using Fluorescence Fingerprints and Principal Component Analysis Read more
Editor’s picks

Honey produced from manuka in New Zealand has exceptionally high antibacterial activity and is approved as a medicine for wound care. In this paper, authors developed a simple and rapid evaluation method for the antibacterial activity of manuka honey by using a fluorescence fingerprint (excitation and emission matrix). Three distinct wavelength combinations of fluorescence were obtained from the honey samples. A correlation between the fingerprint and the antibacterial activity was indicated by a multivariate analysis, and authors succeeded in the evaluation of the activity from the fingerprint. Furthermore, some chemicals (leptosperin and leptosperin) were indicated as antibacterial compounds in the honey.

Volume 68 (2020) Issue 8 Pages 773-778
Risk Prediction Method for Anticholinergic Action Using Auto-quantitative Structure–Activity Relationship and Docking Study with Molecular Operating Environment Read more
Editor’s picks

There are a lot of medicines having anticholinergic actions as side effect. However, it is sometimes difficult to examine side effect only in clinical studies because of various limitations. Therefore, the authors tried to predict anticholinergic activity on the basis of compound’s structures by quantitative structure-activity relationship (QSAR) and docking study. These methods might be helpful for risk assessment of anticholinergic side effects.

Volume 68 (2020) Issue 8 Pages 791-796
Robust Nanoparticle Morphology and Size Analysis by Atomic Force Microscopy for Standardization Read more
Editor’s picks

Because of the complexity of nanomedicines, analysis of their morphology and size has attracted considerable attention. The atomic force microscope (AFM) has emerged as a powerful tool for providing detailed morphological characteristics of nanoparticles. To assess the applicability of standardization of AFM as an analytical methodology of nanomedicines, in this study, authors identified robust conditions for assessing the morphology and size of nanoparticles based on a polystyrene nanoparticle certified reference material standard. Under the optimized conditions, there were no significant inter-instrument differences in the analyzed size values of polystyrene nanoparticles both in air and under aqueous conditions.

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  • Chem. Pharm. Bull. Vol. 68 No. 7
    Current Topics: Recent Progress in Drug Delivery System for Cancer Therapy
  • Chem. Pharm. Bull. Vol. 68 No. 3
    Current Topics: Drug Discovery: Recent Progress and the Future
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