Photographs of tropical and subtropical plants of Madagascar, Thailand, Vietnam, Indonesia and Okinawa, Japan by courtesy of the authors. And some chemical structures of new compounds isolated from these plants are shown. Upper left: Macaranga tanarius and a prenylflavanone, Upper middle: Senna siamea, Upper right: Croton tonkinensis and an ent-Kaurane diterpene, Middle left: Rhinacanthus nasutus, Central middle: Baobab; Adansonia grandidieri, Middle right: Impatiens balsamina, Lower left: Artemisia roxburghiana and X-ray crystallography of a guaianolide, Lower middle: Justicia gendarusa, Lower right: Croton cascarilloides and a plausible biosynthetic pathway of new skeletons.
The authors designed and synthesized a series of cell-penetrating peptides containing cationic proline derivatives (ProGu) that exhibited responsive changes in their secondary structures to the cellular environment. Effects of the peptide length and steric arrangement of the side chain in cationic proline derivatives [Pro4SGu and Pro4RGu] on their secondary structures and cell membrane permeability were investigated. Moreover, peptides 3 and 8 exhibited efficient intracellular delivery of plasmid DNA. These results indicate that the peptides containing cationic proline derivatives could be a useful tool to deliver the hydrophilic biomolecules into the cells.
A practical Pd-catalyzed carbonylation of (hetero)aryl bromides using a crystalline carbon monoxide (CO) surrogate, 2,4,6-trichlorophenyl formate (TCPF), was developed. This reaction proceeds without the slow addition technique that was previously required and with a low catalyst loading (1 mol%) on a gram scale. The utility of this Pd-catalyzed external-CO-free carbonylation using TCPF was demonstrated in the synthesis of a histone deacetylase inhibitor.
In this study, scale-up experiments of the lubricant mixing processes were conducted for V-type blenders under the same condition of fill level and Froude number. Three scales of V-type blender were used for the scale-up experiment. However, the physical properties of them were not corresponded either mixing time or number of revolution. Thus, the DEM simulations of three scales of V-type blender mixing were conducted to find the scale-up factor. As a result, it was found that a scale-up simulation based on the travel distance of particles is valid for lubricant mixing scale-up processes.
The authors established a HPLC-Q-TOF-MS method for rapid analysis of alkaloids in KHR98 (the extract of Uncaria rhynchophylla). A total of eight compounds, including four known alkaloids and four unknown components, were detected and identified. The structural information and fragmentation pathways of eight components were interpreted. A precise and sensitive HPLC-MS method was validated to simultaneously determine these substances. This study shed light on the standardization and quality control of the KHR98 and provided a foundation for the further research on pharmacology, follow-up clinical research and New Drug Applications.
Adsorption of Nitrite and Nitrate Ions from an Aqueous Solution by Fe–Mg-Type Hydrotalcites at Different Molar Ratios
Released: April 01, 2018 | Volume 66 Issue 4 Pages 458-465
Fumihiko Ogata, Noriaki Nagai, Yukine Kariya, Eri Nagahashi, Yuhei Kobayashi, Takehiro Nakamura, Naohito Kawasaki
Molecular Dynamics Simulation-Based Evaluation of the Binding Free Energies of Computationally Designed Drug Candidates: Importance of the Dynamical Effects
Released: July 01, 2014 | Volume 62 Issue 7 Pages 661-667
Takefumi Yamashita, Akihiko Ueda, Takashi Mitsui, Atsushi Tomonaga, Shunji Matsumoto, Tatsuhiko Kodama, Hideaki Fujitani
Methyl Vinyl Ketone, a Toxic Ingredient in Cigarette Smoke Extract, Modifies Glutathione in Mouse Melanoma Cells
Released: August 01, 2014 | Volume 62 Issue 8 Pages 772-778
Shizuyo Horiyama, Yuta Takahashi, Mayuko Hatai, Chie Honda, Kiyoko Suwa, Atsushi Ichikawa, Noriko Yoshikawa, Kazuki Nakamura, Masaru Kunitomo, Sachiko Date, Tsutomu Masujima, Mitsuo Takayama