Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 18,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Ken-ichi Hosoya
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama



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27,207 registered articles
(updated on July 16, 2018)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
1.258
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Featured article
Volume 66 (2018) Issue 7 Pages 748-756
Optimization of Premix Powders for Tableting Use Read more
Editor’s picks

The triangle contour diagram of the Hausner ratio (HR) was represented as a function of lactose (LAC), cornstarch (CS), and microcrystalline cellulose (MCC). The HR is given as the ratio of tapped density to bulk density of powders, and the value is often used as an index of powder fluidity. Although the fluidity of most formulations was acceptable, an increase in the amount of MCC led to poor fluidity (high HR values), which suggested that the upper limit of MCC was required to secure better fluidity of premix powders.

Volume 66 (2018) Issue 7 Pages 732-740
Synthesis and Antimicrobial Activity of 2-Trifluoroacetonylbenzoxazole Ligands and Their Metal Complexes Read more
Editor’s picks

New Zn(II), Mg(II), Ni(II), Cu(II), Pd(II), and Ag(I) complexes of 2-trifluoroacetonylbenzoxazole ligand have been synthesized. Their structures were determined by single-crystal X-ray diffraction analyses. Some metal complexes have more antibacterial effects in comparison with the free ligand. Noticeably, the Ag(I) complex 2h exhibited low MIC value of 0.7 μM against Pseudomonas aeruginosa, which was even superior to Norfloxacin with that of 1.5 μM. 2h is bacteriostatic, exerts the cell surface damage observed by scanning electron microscopy and is less likely to develop resistance. 2h has been found to display effective antimicrobial activity against a series of bacteria.

Volume 66 (2018) Issue 7 Pages 714-720
Carotenoid Stereochemistry Affects Antioxidative Activity of Liposomes Co-encapsulating Astaxanthin and Tocotrienol Read more
Editor’s picks

The antioxidative activity of liposomes co-encapsulating stereoisomer 3S,3’S-astaxanthin (Asx-S) and α-tocotrienol (α-T3) was higher than the calculated additive activity, which results from intermolecular interactions between both antioxidants. The optimal Asx-S/α-T3 ratio for antioxidation was 1:2. Consequently, the Asx stereochemistry affects the intermolecular interaction of Asx/T3, and it was suggested that the intermolecular interaction caused a change in the electronic state of the Asx-S polyene moiety by the presence of double bond in the α-T3 triene moiety.

Volume 66 (2018) Issue 7 Pages 708-713
Protective Effect of Taohong Siwu Decoction on Abnormal Uterine Bleeding Induced by Incomplete Medical Abortion in Rats during Early Pregnancy Read more
Editor’s picks

Abnormal uterine bleeding (AUB) induced by incomplete abortion, which is a common gynecological disease. Taohong Siwu decoction (TSD) has been developed to treat AUB for hundreds of years. In this study, it demonstrated that TSD significantly shortened the duration and reduced the quantity of uterine bleeding. These results suggested that TSD promoted endometrial repair and had a protective effect on uteri. The mechanism may be concerned with up-regulation of the levels of E2 and ERα expression.

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  • Chem. Pharm. Bull. Vol. 66 No. 5
    Current Topics: Natural Products Chemistry of Global Tropical and Subtropical Plants




  • Chem. Pharm. Bull. Vol. 66 No. 3
    Current Topics: Drug Discovery: Recent Progress and the Future

  • Chem. Pharm. Bull. Vol. 66 No. 2
    Current Topics: Medicinal and Bioorganic Chemistry of Nucleosides and Nucleotides



  • Chem. Pharm. Bull. Vol. 66 No. 1
    Current Topics: Recent Progress in Medicinal Chemistry



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