Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 18,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Ken-ichi Hosoya
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama

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27,110 registered articles
(updated on February 21, 2018)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Featured article
Volume 66 (2018) Issue 2 Pages 170-177
Simulation Study on Complex Conformations of Aβ42 Peptides on a GM1 Ganglioside-Containing Lipid Membrane Read more
Editor’s picks

Aggregation of amyloid β-peptide (Aβ) is closely linked to several neurodegeneration diseases including Alzheimer’s disease. Molecular dynamics simulations were performed to clarify the initial stage of Aβs interaction on the lipid membrane that mimicked a micro-domain on the neuronal cell surface. Stable complexes of Aβ peptides were not rapidly generated in simulation, instead a binding of two Aβs was gradually developed. In a stable two Aβs complex, one is bound to the membrane surface, while the other is attached to the first one without strong contact with membrane. A parallel β-sheet structure is formed between the C-terminal sides of them.

Volume 66 (2018) Issue 2 Pages 116
Foreword Read more
Editor’s picks

Nucleosides and nucleotides have fascinated chemists and biologists, because nucleosides and nucleotides are of vital importance not only as components of ribo- and deoxyribonucleic acids in central dogma, but also as a wide variety of biofunctional molecules. This current topic summarized the recent progress on chemical ligation of oligonucleotides, nucleoside antibiotics, unnatural base pairs, antiviral/antitumor nucleoside analogues, protecting groups for oligonucleotide prodrugs, and nucleotide second messengers.

Volume 66 (2018) Issue 2 Pages 105-115
Synthetic Studies on Heteropolycyclic Natural Products: Development of Divergent Strategy Read more
Editor’s picks

Three divergent total syntheses of heteropolycyclic natural product groups, namely gelsedine-type alkaloids, amathaspiramide alkaloids, and erythrina alkaloids, are outlined. These syntheses employed the strategy for designing a late-stage pluripotent common synthetic intermediate that is prepared via the formulation of original and innovative transformations. Brief description of the philosophy and criteria for choosing synthetic targets and common synthetic precursors, as well as the details of development of the overall synthetic schemes mapped around the designed common intermediate are discussed.

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Journal news & Announcements
  • Coming soon
    Current Topics: Medicinal and Bioorganic Chemistry of Nucleosides and Nucleotides

  • Chem. Pharm. Bull. Vol. 66 No. 1
    Current Topics: Recent Progress in Medicinal Chemistry