Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 18,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Ken-ichi Hosoya
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama

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27,074 registered articles
(updated on December 14, 2017)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Featured article
Volume 65 (2017) Issue 12 Pages 1099-1112
Development of Highly Sensitive Analytical Methods for Biologically Relevant Materials and Their Pharmaceutical Applications Read more
Editor’s picks

Analytical methods for disease diagnosis require high sensitivity and specific methods. For neonatal mass screening of congenital metabolic disorders, a 3 mm diameter disc of dried filter paper blood obtained from one drop of newborn blood is used, and one disc contains about 4 μL of blood. Diagnosis is performed by measuring hormones and genes in this disc. In hormone analysis, chemiluminescent enzyme immunoassay was developed. In genetic analysis, pyrophosphate generated by PCR amplification reaction or DNA fragment as amplification product was analyzed by luciferase bioluminescence method and capillary electrophoresis, respectively. In addition, identification of reactive oxygen species generated from natural medicines and antianginal drugs and their physiological action mechanism are described.

Volume 65 (2017) Issue 12 Pages 1167-1174
Synthesis of Tetrahydrobiphenylene via Pd(0)-Catalyzed C(sp2)–H Functionalization Read more
Editor’s picks

This paper describes the development of a synthetic method for tetrahydrobiphenylenes and derivatives based on a palladium(0)-catalyzed C(sp2)−H functionalization. This is a new direct method for accessing partially hydrogenated biphenylenes. The derivatization of a tetrahydrobiphenylene is also reported.

Volume 65 (2017) Issue 12 Pages 1144-1160
Novel Non-carboxylate Benzoylsulfonamide-Based Protein Tyrosine Phosphatase 1B Inhibitors with Non-competitive Actions Read more
Editor’s picks

A novel series of benzoylsulfonamide derivatives were synthesized and biologically evaluated. Among them, compound 18K was shown to inhibit protein tyrosine phosphatase 1B (PTP1B) activity potently and non-competitively (IC50=0.25 μM). Molecular dynamics simulation demonstrated that 18K binds to the allosteric site of PTP1B. Compound 18K showed high oral absorption in mice, rats, and beagles, and markedly reduced plasma glucose levels, TG levels, and HOMA values with no side effects at 30 mg/kg (p.o.) for one week in db/db mice. In conclusion, the substituted benzoylsulfonamide is a novel scaffold of non-competitive allosteric PTP1B inhibitors, and compound 18K is a promising candidate for an efficacious and safe anti-diabetic drug with anti-obesity effects.

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Journal news & Announcements
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    Current Topics: Medicinal and Bioorganic Chemistry of Nucleosides and Nucleotides

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