Aggregation of amyloid β-peptide (Aβ) is closely linked to several neurodegeneration diseases including Alzheimer’s disease. Molecular dynamics simulations were performed to clarify the initial stage of Aβs interaction on the lipid membrane that mimicked a micro-domain on the neuronal cell surface. Stable complexes of Aβ peptides were not rapidly generated in simulation, instead a binding of two Aβs was gradually developed. In a stable two Aβs complex, one is bound to the membrane surface, while the other is attached to the first one without strong contact with membrane. A parallel β-sheet structure is formed between the C-terminal sides of them.
Nucleosides and nucleotides have fascinated chemists and biologists, because nucleosides and nucleotides are of vital importance not only as components of ribo- and deoxyribonucleic acids in central dogma, but also as a wide variety of biofunctional molecules. This current topic summarized the recent progress on chemical ligation of oligonucleotides, nucleoside antibiotics, unnatural base pairs, antiviral/antitumor nucleoside analogues, protecting groups for oligonucleotide prodrugs, and nucleotide second messengers.
Three divergent total syntheses of heteropolycyclic natural product groups, namely gelsedine-type alkaloids, amathaspiramide alkaloids, and erythrina alkaloids, are outlined. These syntheses employed the strategy for designing a late-stage pluripotent common synthetic intermediate that is prepared via the formulation of original and innovative transformations. Brief description of the philosophy and criteria for choosing synthetic targets and common synthetic precursors, as well as the details of development of the overall synthetic schemes mapped around the designed common intermediate are discussed.
In Vitro Anti-Propionibacterium Activity by Curcumin Containing Vesicle System
April 01, 2013 | Volume 61 Issue 4 Pages 419-425
Chi-Hsien Liu, Hsin-Ying Huang
INHIBITORS OF PROSTAGLANDIN BIOSYNTHESIS FROM GINGER
March 31, 2008 | Volume 30 Issue 2 Pages 754-757
Fumiyuki Kiuchi, Masaaki Shibuya, Ushio Sankawa
Fluorescent Imaging Analysis for Distribution of fluorescent dye labeled- or encapsulated- liposome in Monocrotaline-induced Pulmonary Hypertension model rat
January 06, 2018 |
Article ID c17-00811
Yo Muraki, Midori Yamasaki, Hirohisa Takeuchi, Kimio Tohyama, Noriyasu Sano, Takanori Matsuo
New Cannabinoid-Like Chromane and Chromene Derivatives from Rhododendron anthopogonoides
November 01, 2011 | Volume 59 Issue 11 Pages 1409-1412
Naoki Iwata, Susumu Kitanaka