Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 18,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Ken-ichi Hosoya
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama

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27,194 registered articles
(updated on June 23, 2018)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Featured article
Volume 66 (2018) Issue 6 Pages 660-667
Mirilactams C–E, Novel Polycyclic Macrolactams Isolated from Combined-Culture of Actinosynnema mirum NBRC 14064 and Mycolic Acid-Containing Bacterium Read more
Editor’s picks

Actinobacteria are the rich source of natural products while the large parts of biosynthetic gene clusters (BGCs) are silent under the standard culture conditions. The authors previously demonstrated that co-culture with mycolic acid-containing bacterium (MACB) effectively activates the silent BGCs in actinobacteria. In this study, the authors investigated the actinobacterium which produces a polyene macrolactam, mirilactam A. The authors tested co-culture of the mirilactam A producer strain with MACB, and successfully obtained three novel polycyclic macrolactams, mirilactams C-E, by activating silent biosynthetic genes responsible for the epoxidation and cyclization of the polyene mirilactam A.

Volume 66 (2018) Issue 6 Pages 642-650
Identification of Two Phenanthrene Derivatives from Australasian Allied Species in Genus Dendrobium Read more
Editor’s picks

The genus Dendrobium (Orchidaceae) is comprised of more than 1,000 species and divided into two major groups, Asian and Australasian clades. There are many ethnobotanical important species in this genus and various phenanthrenes and bibenzyl derivatives have been isolated from Dendrobium in previous studies. Secondary metabolites produced by species of the Australasian clade have not been studied well, even though several species of this group have also been used as traditional herbal remedies. The authors provide an overview of secondary metabolites of Dendrobium by combined non-target metabolomics and multivariate analysis, and identified characteristic compounds from several closely related Australasian species.

Volume 66 (2018) Issue 6 Pages 632-636
Estimating the Diffusion Coefficients of Sugars Using Diffusion Experiments in Agar-Gel and Computer Simulations Read more
Editor’s picks

This article describes the estimation of the diffusion coefficients of sugars and a related compound.  A simple and handy experimental system with agar-gel was built and used to observe diffusion of small molecules. The correlation formulas derived from computer simulations of the experimental diffusion system were then applied to estimate diffusion coefficients. The values obtained for these coefficients agree reasonably well with those published in the literature. This finding supports the efficacy of the approach for estimating diffusion coefficients, leading to the elucidation of the diffusion coefficients of galactose, trehalose and glycerol.

Volume 66 (2018) Issue 6 Pages 624-631
Stable and Selective Antiparallel Type Triplex DNA Formation by Targeting a GC Base Pair with the TFO Containing One N2-Phenyl-2′-deoxyguanosine Read more
Editor’s picks

The antiparallel triplex DNA is formed by the interaction between purine-rich triplex forming oligonucleotides (TFOs) and the homo-purine region within a duplex DNA. The formation of such a structure with the genome DNA promises to control the gene expression in a living cell. In this paper, in an attempt to enhance the stability of the triplex DNAs, the authors have designed and synthesized the N2-arylated deoxyguanosine derivatives. The TFOs containing N2-phenyl-2′-deoxyguanosine (PhdG) showed a stable and selective triplex DNA formation with the GC base pair as compared to the natural dG/GC triplet.

Volume 66 (2018) Issue 6 Pages 602-607
Modeling Analysis of Potential Target of Dolastatin 16 by Computational Virtual Screening Read more
Editor’s picks

Dolastatin 16 is a cyclic depsipeptide isolated from cyanobacterium Lyngbya majuscula, however, its bioactivity has been a historical question. In this study, FKBP1A was predicted as a potential target of dolastatin 16 via PharmMapper as well as verified using chemical-protein interactome (CPI) and molecular docking. The lowest binding energy of dolastatin 16-FKBP1A complex was -7.4 kcal/mol. The ligand dolastatin 16 formed three hydrogen bonds and seven hydrophobic interactions within the active site residues. And the pharmacophore model was shown feasibly matching with the molecular feature of dolastatin 16.

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Journal news & Announcements
  • Chem. Pharm. Bull. Vol. 66 No. 5
    Current Topics: Natural Products Chemistry of Global Tropical and Subtropical Plants

  • Chem. Pharm. Bull. Vol. 66 No. 3
    Current Topics: Drug Discovery: Recent Progress and the Future

  • Chem. Pharm. Bull. Vol. 66 No. 2
    Current Topics: Medicinal and Bioorganic Chemistry of Nucleosides and Nucleotides

  • Chem. Pharm. Bull. Vol. 66 No. 1
    Current Topics: Recent Progress in Medicinal Chemistry