Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 18,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Ken-ichi Hosoya
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama



Read more
27,369 registered articles
(updated on May 19, 2019)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
1.258
2017 IMPACT FACTOR
JOURNALS PEER REVIEWED FREE ACCESS FULL-TEXT HTML ADVANCE PUBLICATION
Featured article
Volume 67 (2019) Issue 5 Pages 397-403
Nickel-Catalyzed Hydrocyanation of Allenes and Its Application Read more
Editor’s picks

Regioselective cyanation of simple and non-activated carbon–carbon bonds catalyzed by nickel complexes is described. This protocol enables to use of the substituted allenes for regio- and stereocontrolled transformations and their applications for cyclization, 3-component coupling reaction, heterocycle formation as well as natural product synthesis are demonstrated. The author reveals the origin of the above selectivity by axial chirality transfer process using optically active allenes as substrates. Steric bulk of substituents is found to be a key factor for discrimination of allenyl carbon–carbon double bonds in hydrometallation step.

Volume 67 (2019) Issue 5 Pages 439-444
Measurement of Linezolid and Its Metabolites PNU-142300 and PNU-142586 in Human Plasma Using Ultra-Performance Liquid Chromatography Method Read more
Editor’s picks

This paper describes the development and validation of a method for measuring linezolid and its metabolites PNU-142300 and PNU-142586 in human plasma, using ultra-performance liquid chromatography (UPLC) method. This method enables the simultaneous measurement of these three components within 3 min. Further, plasma concentrations of linezolid, PNU-142300 and PNU-142586 in patients treated with linezolid could be measured. The developed method is a useful tool for therapeutic drug monitoring and clinical pharmacokinetic/pharmacodynamic (PK/PD) profiling of linezolid, as well as for dose optimization during treatment.

Volume 67 (2019) Issue 5 Pages 461-466
Study on Control of pH-Modulation Crystallization Utilizing Concept of Dissociation Equilibrium Read more
Editor’s picks

3-Alkenyl cephem compound is a pharmaceutical intermediate. It is typically crystalized by pH adjustment method. However, since the filtration time in the solid-liquid separator is a bottleneck in the production, there is a need to control crystal morphology while changing the pH. This study could be shorten filtration time by pH-modulation operation that repeating the crystallization operation in the vicinity of solubility. The obtained monodisperse particles were like a pseudo-growth body in which a large number of primary particles were aggregated and increased, rather than being a crystallite growth.

Volume 67 (2019) Issue 5 Pages 476-480
The Revised Structure of the Cyclic Octapeptide Surugamide A Read more
Editor’s picks

Surugamide A, a non-ribosomal peptide with cathepsin B inhibitory activity, and its closely related derivatives, surugamides B-E are cyclic octapeptides produced by several Streptomyces species. All these peptides except for surugamide B contain a D-Ile residue that involve Cβ-epimerization step during its biosynthesis. However, the genes responsible for this conversion is absent in the biosynthetic gene cluster of surugamides. To clarify this issue, surugamide A containing D-Ile as well as its epimer having D-allo-Ile were synthesized. HPLC and Marfey’s analyses showed that surugamide A actually possesses D-allo-Ile instead of D-Ile, requiring structural collection of this group of peptides.

View the past featured articles
View all articles in Current issue
Most viewed articles Apr.2019
Share this page
Select past volume & issue
Journal news & Announcements
  • Chem. Pharm. Bull. Vol. 67 No. 4
    Current Topics: Recent Progress in Biophysical Research of Biological Membrane Systems



  • Chem. Pharm. Bull. Vol. 67 No. 3
    Current Topics: Drug Discovery: Recent Progress and the Future




feedback
Top