Chemical and Pharmaceutical Bulletin

The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 18,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Ken-ichi Hosoya
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama

Published by The Pharmaceutical Society of Japan

27,350 registered articles
(updated on April 22, 2019)

Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363

1.258
2017 IMPACT FACTOR

JOURNALS PEER REVIEWED FREE ACCESS FULL-TEXT HTML ADVANCE PUBLICATION

Featured article

Volume 67 (2019) Issue 4 Pages 367-371

A Simple and Easy Method of Monitoring Doxorubicin Release from a Liposomal Drug Formulation in the Serum Using Fluorescence Spectroscopy

Ayako Watanabe, Shuhei Murayama, Koji Karasawa, Eiichi Yamamoto, Satoru Morikawa, Ryo Takita, Shigeo Murata, Masaru Kato

Formulation of a drug as liposomes facilitates its delivery to the disease target. Rightly, liposomes are gaining popularity in the medical field. In order for the drug to show efficacy, release of the encapsulated drug from the liposome at the target site is required. However, the release is affected by the permeability of the lipid bilayer of the liposome, and it is important to examine the effect of the surrounding environment on the permeability. In this study, we showed the usefulness of fluorescence analysis, especially fluorescence fingerprint, for a rapid and simple monitoring of release of an encapsulated anticancer drug (doxorubicin) from its liposomal formulation (DOXIL). Our result indicated that the release is accelerated by the existence of membrane permeable ions, such as tris(hydroxymethyl)aminomethane, and blood proteins like albumin. Hence, monitoring of doxorubicin release by fluorescence analysis is useful for the efficacy evaluation of DOXIL in a biomimetic environment.

Editor’s picks

In order to maximize the effect of drugs, nanomedicines, drug-containing nanoparticles, have become popular in the field of medicine as they allow selective delivery of drugs to the disease target. It is important to understand the drug release form nanomedicine at the disease target. In this study, the authors developed a simple and easy method of monitoring drug release from nanomedicine using a fluorescence analysis, especially fluorescence fingerprint. The authors used DOXIL as a typical nanomedicine and found out that the release of the encapsulated drug, doxorubicin, is accelerated by albumin which is the most abundant protein in the blood.

Volume 67 (2019) Issue 4 Pages 289-298

Cyclodextrin-Based Molecular Accessories for Drug Discovery and Drug Delivery

Taishi Higashi

Recently, active pharmaceutical ingredients (APIs) have been dramatically expanding from low-molecular weight drugs to peptides, proteins, antibodies, genes, oligonucleotides, cells, and machines. Therefore to develop pharmaceutical technologies and drug delivery systems (DDS) for these APIs, advanced molecules and novel concepts are needed. In this review, we introduce cyclodextrin-based supramolecular accessories such as molecular necklace, molecular earring, and intelligent molecular necklace, and describe their application for pharmaceutical technology and DDS. In addition, we also introduce utility of supramolecular accessories as antitumor drugs. Finally, we propose a new concept in pharmaceutical sciences termed as “supramolecular pharmaceutical sciences,” which combines pharmaceutical sciences and supramolecular chemistry. This concept could be useful for developing new ideas, methods, hypotheses, strategies, materials, and mechanisms in pharmaceutical sciences.

Editor’s picks

A person may choose to wear an accessory so as to enhance their appearance and give them confidence and thus a change of character. So what happens when accessories are decorated with drugs? The author has developed molecular accessories for drugs through supramolecular chemistry to create new medicines and pharmaceutical technologies. In this article, the author introduces cyclodextrin-based supramolecular accessories such as molecular necklace, molecular earring, and intelligent molecular necklace, and describes their application in pharmaceutical sciences. Moreover, the author proposes a new concept in pharmaceutical sciences termed as “supramolecular pharmaceutical sciences,” which combines pharmaceutical sciences and supramolecular chemistry.

View the past featured articles

2019 Volume 67 Issue 4

Structure and Function of Δ9-Fatty Acid Desaturase Kohjiro Nagao, Akira Murakami, Masato Umeda
Discovery of Novel PRMT5 Inhibitors by Virtual Screening and Biological Evaluations Hongrui Tao, Xue Yan, Kongkai Zhu, Hua Zhang
Evaluation of Interbilayer and Transbilayer Transfer Dynamics of Phospholipids Using Time-Resolved Small-Angle Neutron Scattering Minoru Nakano
Bilayer Tablet Dissolution Kinetics Based on a Degassing Cyclic Flow UV-Vis Spectroscopy with Chemometrics Yuta Otsuka, Akira Ito, Toru Takahashi, Saki Matsumura, Masaki Takeuchi, Hideji Tanaka

View all articles in Current issue

Register with J-STAGE for free!