Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 18,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Sumio Ohtsuki
Faculty of Life Sciences, Kumamoto University

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27,709 registered articles
(updated on January 24, 2021)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
2019 Journal Impact Factor (JIF)
Scopus Pubmed
Featured article
Volume 69 (2021) Issue 1 Pages 48-51
Four New Pregnane-10,2-carbolactones from an Epipolasis sp. Marine Sponge Read more
Editor’s picks

The extract of an Epipolasis sp. marine sponge collected in the Republic of Palau provided four new pregnane 10,2 carbolactone derivatives. The structures of these rare pregnane analogues were fully elucidated through HRMS measurements and detailed analysis of their one- and two-dimensional NMR spectroscopic data. Pregnane steroids possessing a 10,2-carbolactone ring have only been reported previously from Hawaiian collections of Myrmekioderma and Petrosia (Stongylophora) sponges, so the current results suggest this class of steroid is more widely distributed in the marine environment than previously recognized.

Volume 69 (2021) Issue 1 Pages 72-80
Phase Separation in Lipid Lamellae Result from Ceramide Conformations and Lateral Packing Structure Read more
Editor’s picks

The packing structure of intercellular lipids in the stratum corneum plays a critical role in the skin’s barrier function. The mechanism of packing structure disruption is not fully understood. The authors constructed models for collapsed skin intercellular lipids composed of short-chain free fatty acids and α-hydroxy ceramide. To investigate the packing structure’s characteristics, they changed the lipid composition and used temperature-scanning, simultaneous small-angle and wide-angle X-ray diffraction to determine resulting structural changes. The results suggest a change in ceramide conformation into a V-shape structure. The authors discussed the relationship between the V-shape structure formation and a reduction in the skin’s barrier function.

Volume 69 (2021) Issue 1 Pages 92-98
Characteristics of Raw and Acid-Activated Bentonite and Its Application for Improving Electrical Conductivity of Tap Water Read more
Editor’s picks

Authors evaluate the characteristics of acid-activated bentonite by focusing on its capability of improving the quality of tap water used during wire electrical discharge machining. This study shows that the acid activation of bentonite using sulfuric acid, nitric acid, and phosphoric acid solutions increases the specific surface area and pore volume. Additionally, authors revealed that the relationship between the concentrations of the removed ions and electrical conductivity were negatively correlated (correlation coefficient: -0.950). Thus, the acid-activated bentonite is useful in controlling the reduction in the electrical conductivity of tap water.

Volume 69 (2021) Issue 1 Pages 118-123
Absolute Purity Determination of a Hygroscopic Substance, Indocyanine Green, Using Quantitative NMR (qNMR) Read more
Editor’s picks

Quantitative NMR (qNMR) has emerged as a new absolute quantitation method for small molecules. Authors examined the absolute purity determination of a hygroscopic substance indocyanine green (ICG) using qNMR. The three different humidity conditions yielded comparable purity means of 86.12 ± 2.70%, 84.19 ± 0.47%, and 82.26 ± 0.19% under non-controlled humidity, controlled humidity using a saturated NaBr solution, and using a constant temperature and humidity box, respectively. As the results using the constant temperature and humidity box showed the lowest variability, it is recommended to use it if the reference standard of ICG with its purity value is needed for Japanese Pharmacopoeia assays.

Volume 69 (2021) Issue 1 Pages 124-140
β-Selective Glycosylation Using Axial-Rich and 2-O-Rhamnosylated Glucosyl Donors Controlled by the Protecting Pattern of the Second Sugar Read more
Editor’s picks

Stereoselectivity in chemical glycosylation frequently varies in reaction substrates. This paper describes the influence of the protecting groups on rhamnose connected to the 2-O position of a glucosyl donor with axial-rich conformation on stereoselectivity in its glycosylation with cholestanol. The authors revealed that two bulky silyl groups existing at the 3-O and 4-O positions of rhamnose synergistically enhanced β-selectivity. In contrast, the silyl group introduced to the 2-O position decreased the selectivity. These results suggest that appropriately designing a protecting-group pattern for another sugar far from the reaction center of a glycosyl donor can control the stereoselectivity of glycosylation.

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Announcements from publisher
  • Chem. Pharm. Bull. Vol. 69 No. 1
    Current Topics: Pharmaceutical Research for Quality Evaluation and Characterization of Foods and Natural Products
  • Chem. Pharm. Bull. Vol. 68 No. 12
    Current Topics: New Era of Polyphenol Research