Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 15,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Sumio Ohtsuki
Faculty of Life Sciences, Kumamoto University
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27,973 registered articles
(updated on August 19, 2022)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
2021 Journal Impact Factor (JIF)
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Featured article
Volume 70 (2022) Issue 8 Pages 506
Foreword Read more
Editor's pick

Biomembranes constitute the boundary between the living organism and the external environment, and their function is essential for maintaining biological activities. Quantitative understanding and precise control of the transport and conversion of various substances across biomembranes are important issues in biophysics and cell biology, but dealing with biomembranes, which are multi-component, heterogeneous, and complex systems, is not an easy task. In the Current Topics, investigators who are boldly tackling this area of research introduce recent advances in biophysical and molecular biological aspects and technology.

Volume 70 (2022) Issue 8 Pages 540-543
Site-Selective α-Alkylation of 1,3-Butanediol Using a Thiophosphoric Acid Hydrogen Atom Transfer Catalyst Read more
Editor's pick

The linear 1,3-diol structure is a common motif in biologically active molecules. C-H functionalization at an α-position of alcohols leads to efficient synthesis of sugars and polyols. However, regioselective conversions at the alcohol α-position of linear 1,3-diols have been limited. Nakao et al. developed secondary-alcohol-selective C-H alkylation of 1,3-butane diol by combining an acridinium photoredox catalyst and a thiophosphoric acid hydrogen atom transfer (HAT) catalyst. The use of DCM as a solvent with a relatively small dipole moment improved secondary α-alkoxy C-H selectivity by making the C-H abstraction process the rate-limiting step.

Volume 70 (2022) Issue 8 Pages 558-565
Determination of Hardness of a Pharmaceutical Oral Jelly by Using T2 Relaxation Behavior Measured by Time-Domain NMR Read more
Editor's pick

Hardness is a critical quality characteristic of pharmaceutical oral jelly. The purpose of this study is to determine the hardness using time-domain NMR (TD-NMR). After measurement of the T2 relaxation curves of the test jellies by TD-NMR, the acquired data were analyzed by partial least squares (PLS) regression analysis. Eventually, an accurate and reliable PLS model was created that enabled accurate assessment of the hardness of the test jellies. TD-NMR enables the measurement of samples nondestructively and rapidly with low cost, and so could be a promising method for evaluation of the hardness of pharmaceutical oral jellies.

Volume 70 (2022) Issue 8 Pages 566-572
Aryne Generation from o-Triazenylarylboronic Acids Induced by Brønsted Acid Read more
Editor's pick

This paper describes acid-mediated aryne generation from o-triazenylarylboronic acids. The authors previously reported these practical aryne precursors generate arynes by the treatment with silica gel. In this paper, they reported acids including Brønsted acids, Lewis acids, and solid acids are also effective for aryne generation from the precursors. In particular, the use of camphorsulfonic acid provided high yields in reactions with a range of arynophiles, and enabled chemoselective reaction with a furan in the presence of an amine. Hammett plot analyses revealed that an aryne generation mechanism induced by the acid is distinct from the mechanism induced by silica gel.

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Announcements from publisher
  • Chem. Pharm. Bull. Vol. 70 No. 8
    Current Topics: Recent Progress in Research on Membrane Dynamics and Membrane Transport
  • Chem. Pharm. Bull. Vol. 70 No. 5
    Current Topics: New Modalities and Strategies in Drug Delivery and Discovery
  • Announcement of Academic Journals’ Awards
    Chemical and Pharmaceutical Bulletin (CPB)
  • Chem. Pharm. Bull. Vol. 70 No. 1
    Current Topics: Liquid Chromatographic Techniques in Food Sciences
  • Chem. Pharm. Bull. Vol. 69 No. 10
    Current Topics: Analytical Chemistry in Biology and Medicine