Drug Delivery System
Online ISSN : 1881-2732
Print ISSN : 0913-5006
ISSN-L : 0913-5006
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Volume 26, Issue 5
Displaying 1-5 of 5 articles from this issue
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Feature articles “DDS in pain relief” Editor : Yasuhiro Matsumura
  • Current state and future of topically applied drug formulations against pain relief
    Kenji Sugibayashi
    2011 Volume 26 Issue 5 Pages 450-456
    Published: 2011
    Released on J-STAGE: January 17, 2012
    DOIhttps://doi.org/10.2745/dds.26.450
    JOURNAL FREE ACCESS
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    Topical formulations containing NSAIDs or anesthetics and transdermal delivery systems of(narcotic and non-narcotic)opioid analgesics are presently used for cure and relief of pain in Japan. Second generation of NSAID tape and hydrogel formulations enable direct migration of the drugs into the pain sites under the skin, resulting in typical DDS for the NSAID topical formulations.
    Lidocain tape is also applied for the pain relief caused by injection using intravenous indwelling needles, whereas lidocain hydrogel is utilized for pain relief in the postherpetic neuralgia in USA. Transdermal opioid delivery systems are mostly paid attention as the present and future items to be developed. Fentanil and buprenorphine patches are of examples. Combination products with the patches and iontophoresis/microneedles, and transdermal delivery systems containing analgesic additives or adjuvants are future R & D issues for the pain relief.
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  • NGF and pain
    Atsushi Yamaguchi
    2011 Volume 26 Issue 5 Pages 457-460
    Published: 2011
    Released on J-STAGE: January 17, 2012
    DOIhttps://doi.org/10.2745/dds.26.457
    JOURNAL FREE ACCESS
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    NGF(Nerve growth factor)is essential for neuronal development, survival and maintenance. NGF plays a critical role in the generation of chronic pain, and its antagonism is expected to be an effective therapy. Recent advances in the research field are summarized in this review.
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  • Opioids in cancer pain management
    Seiji Hattori, Tae Igarashi, Junko Takarada, Hiromi Sano, Tsutomu Oshi ...
    2011 Volume 26 Issue 5 Pages 461-467
    Published: 2011
    Released on J-STAGE: January 17, 2012
    DOIhttps://doi.org/10.2745/dds.26.461
    JOURNAL FREE ACCESS
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    Opioid is golden standard medication for treating cancer pain. Manufacturers had provided many kinds of drug preparation in order to ease cancer pain treatment. Oral, suppository, transdermal and injections. This paper will outline current status of opioid preparation in Japan.
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  • DDS of nonsteroidal anti-inflammatory drugs(NSAIDs)
    Natsuko Kusunoki, Shinichi Kawai
    2011 Volume 26 Issue 5 Pages 468-475
    Published: 2011
    Released on J-STAGE: January 17, 2012
    DOIhttps://doi.org/10.2745/dds.26.468
    JOURNAL FREE ACCESS
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    A lot of topical NSAIDs have been developed to reduce adverse reactions such as gastrointestinal events. Oral selective COX-2 inhibitors are considered as molecular targeting DDS. They could obviously reduce gastrointestinal event, however, incidences of other adverse reactions such as cardiovascular or renal events might not be changed when compared with conventional NSAIDs.
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  • Current development in analgesic administration routes
    Yoshihisa Matsumoto, Hiroya Kinoshita
    2011 Volume 26 Issue 5 Pages 476-479
    Published: 2011
    Released on J-STAGE: January 17, 2012
    DOIhttps://doi.org/10.2745/dds.26.476
    JOURNAL FREE ACCESS
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    The use of analgesics and adjuvant analgesics are often limited because of adverse effects or limited administration routes. The ideal analgesic would be expected to have adequate analgesic effects with minimum adverse events and have multiple administration routes and absorption pathways.
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