The present study investigated changes in extremity muscle mass of obese middle-aged and elderly women who lost weight by participating in a diabetes prevention program. Subjects comprised 15 consenting middle-aged and elderly obese women with ≥30% body fat (mean age, 62.7±2.3 years). For estimation of body composition, including extremity muscle mass, a 12-lead bioelectrical impedance muscle analyzer was used (Muscle-α, 50 kHz, 500 μA). Muscle mass of the forearm, upper arm, thigh and lower leg was measured. The diabetes prevention program lasted 6 months and mainly comprised nutrition and exercise guidance. Subjects participated in water-based exercises once a week and performed strength training on their own at home. After the program, body weight, fat mass and fat-free mass were significantly decreased (body weight: -2.6±1.0 kg; fat mass: -1.2±1.0 kg; and fat-free mass: -1.4±0.6 kg). The present study measured extremity muscle mass, and the results confirmed that as body weight decreased, muscle mass of the extremities (forearm, thigh and lower leg) decreased significantly. The degree of decrease was significantly higher for the lower leg than for other segments. Furthermore, degree of decrease was significantly higher for leg muscle mass than for arm muscle mass. The reduction in leg muscle mass due to body weight loss was attributable to the leg having to support less weight, or in other words, physiological adaptation. In addition, the degree of decrease in muscle mass of the thigh was lower than that of the lower leg, and this was attributed to water-based exercise and home strength training suppressing decreases in muscle mass loss.
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