A thin-film coating of hexamethyldisiloxane (HMDSO) and an O
2-plasma treatment were carried out on titanium (Ti) plates. The contact angle of HMDSO-coatings without O
2-plasma treatment against double-distilled water was more than 100 degrees, and dramatically decreased after the O
2-plasma treatment with less than 5 degrees, resulting superhydrophilicity. Cell proliferation and the alkaline-phosphatase activity of osteoblast-like cells increased on the surfaces of HMDSO-coating with O
2-plasma treatment compared to on the Ti and HMDSO-coatings without O
2-plasma treatment. SEM observation revealed that the cultured cells were spread on O
2-plasma modified surfaces. These results indicated that HMDSO-coating with O
2-plasma treatment was a promising for fabricating with osteogenesis surface of scaffolds.
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