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Volume 1988, Issue Supplement26
Displaying 1-5 of 5 articles from this issue
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Tetsuya Shima1988 Volume 1988 Issue Supplement26 Pages 1-14
Published: September 30, 1988
Released on J-STAGE: November 27, 2012
JOURNAL FREE ACCESSArachidonic acid metabolites in nasal secretion, retention fluid and the nasal mucosa were investigated. The nasal secretion was obtained from patients with chronic sinusitis, and the retention fluid was from post-operative maxillary sinus cyst. The mucosa of the inferior turbinates in hypertrophic rhinitis, the nasal polyps and the sinus mucosa in chronic sinusitis were also investigated. Leukotriene (LT)B4,5-,12- and 15hydroxyeicosatetraenoic acid (HETE) were analyzed by reverse-phase high performance liquid chromatography and spectrophotometry, and LTC4, D4 and E4 were analyzed by RP-HPLC.
The levels of LTB4 and 5-HETE in nasal secretion and mucosae were higher than the concentration that induced chemotactic activity in polymorphonuclear cells. The predominant metabolites of arachidonic acid in the nasal mucosae were 12- and 15-HETE, and that in nasal secretion was 12-HETE. Sulfidopeptide LTs such as LTC4, D4, E4 were detected, even in non-allergic samples.
LTB4 and 5-HETE are presumed to ha ve important roles in nasal mucosal inflammation with leukocytes migration. The roles of 12- and 15-HETE in the nasal mucosa also seemed to be important because of their predominance in the arachidonic acid cascade. LTC4, D4, E4, which are slow-reacting substances in anaphilaxis, were considered to mediate not only nasal allergy but also the inflammation of the nasal mucosae.View full abstractDownload PDF (2445K) -
Yasuhiro Miyazaki1988 Volume 1988 Issue Supplement26 Pages 15-31
Published: September 30, 1988
Released on J-STAGE: November 27, 2012
JOURNAL FREE ACCESSWe have developed a contact Nd-YAG laser technique with excellent incisional capabilities. The effects of the contact Nd-YAG laser irradiation on the wound healing in the rabbit skin and tongue was evaluated with respect to, (1) histological and immunohistochemical findings, (2) hydroxyproline levels in the wound and (3) reduction in the initial wound area. The histology and immunohistochemistry of the specimens treated by a contact Nd-YAG laser irradiation at 14 watts revealed numerous neutrophils and histiocytes with strong inflammatory reaction in the region adjacent to the incised areas 3 and 7 days after operation. Fibronectin could be seen around the incised areas. On the 12th day, inflammatory cells could still be seen, although the wound healing characterized by fibrosis and regeneration of the epithe lium was in advanced stages. The hydroxyproline levels in the wounds were signifi-- cantly lower in the laser groups 3 and 7 days after operation than in the surgical scalpel group (control group). On the 14th day, the level was slightly lower in the laser groups than in the control group. The reduction in the initial wound area in the laser groups, especially in the group irradiated at 14 watts, was slightly delayed compared to that in the control group. These findings suggested that the cure of wound, especially within 7 days after operation was slightly delayed following contact Nd-YAG laser irradiation at 14 watts compared to that by using the usual surgical scalpel. The contact Nd-YAG laser technique was clinically applied to the surgical operation of head and neck diseases in 238 patients: 105 malignant head and neck tumors,32 with benign tumors,96 with inflammatory diseases and 5 with other diseases. Satisfactory results were obtained. It was suggested that under appropriate irradiation conditions, the contact Nd-YAG laser technique was useful for operation of head and neck diseases.View full abstractDownload PDF (23820K) -
Ryuji Kiyota1988 Volume 1988 Issue Supplement26 Pages 32-37
Published: September 30, 1988
Released on J-STAGE: November 27, 2012
JOURNAL FREE ACCESSIt has been reported that healthy persons with normal hearing and without complain of tinnitus have perceivable tinnitus, when the ambient noise level is low. Such tinnitus was observed in 44 (72.1%) of 61 healthy adults with normal hearing in a sound-proof room. In most (91%) of them, tinnitus resembled pure tone, and was composed of middle or high pitch tone.
Since their frequency was conce n trated in some ranges relating to each other as multiples, it is suggested that some resonance mechanism in the body is involved in the generation of this type of tinnitus.View full abstractDownload PDF (3527K) -
Ryuji Kiyota1988 Volume 1988 Issue Supplement26 Pages 38-47
Published: September 30, 1988
Released on J-STAGE: November 27, 2012
JOURNAL FREE ACCESSThe effects of intravenous administration of lidocaine (1 mg/kg) on tinnitus perceived by normal adults in a sound-proof room were compared with those in patients with hearing disorders. Intravenous administration of lidocaine caused a 50-100%reduction of subjective loudness of tinnitus in 36 of 68 patients, but in only 2 of 19 normal subjects in the sound-proof room. It was interesting that subjective loundness of tinnitus was enhanced in 15 of the latter. Lidocaine had no effect on hearing threshold. However, hearing threshold of the subjects with tinnitus in the sound-proof room, who exhitited increased loudness, revealed a tendency to rise at a pitch of their tinnitus.
These results suggest that the generation of this type of tinnitus stems from change of activity of some inhibitory neurons. This study showed that th e effect of lidocaine differed with the kind of tinnitus.
Thus intravenous administration of lidocaine may be useful for differential diagnosis of tinnitus.View full abstractDownload PDF (1881K) -
Shoji Matsune1988 Volume 1988 Issue Supplement26 Pages 48-63
Published: September 30, 1988
Released on J-STAGE: November 27, 2012
JOURNAL FREE ACCESSTo elucidate the pathogenesis of sinusitis, the microvasculature and surface- ultrastructure of ostium in rabbits were examined by scanning electron microscopy, in addition to histochemical investigation of the mucosa.
The scanning electron microscopic obse r vation by the injection replica method revealed that the microvasculature around the ostium was different from that in other parts of the nasal cavity such as the nasal turbinate and septal mucosa. Capillaries around the ostium had a relatively flat and reticular structure, whereas those in the turbinate had a three dimensional network composed of many loops.
Histochemical study on ostium mucosa was performed in rabbi t s with experimentally induced sinusitis. The rabbits were divided into three groups; a) a control group, b) a sensitization group with egg albumin, c) a sinusitis group induced by injection of endotoxin of H. Influenzae after egg albumin sensitization.
The number of goblet cells lining the surface of the epi t h elium around the ostium was higher but that of ciliated cells was lower in both the sensitization and the sinusitis groups than in the control group. A characteristic findings was that reaction products were observed in the goblet cells stained with lectins, which bind to specific sugar residues, in all of the groups.
It was concluded that the pathogenesis of the sinusitis was closely related to the pathology of the ostium.View full abstractDownload PDF (16877K)
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