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Ryo Omura
1988 Volume 1988 Issue Supplement27 Pages
1-16
Published: October 30, 1988
Released on J-STAGE: November 27, 2012
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The effect of Gentamicin on the vestibular system was studied using bullfrogs. The ototoxicity was compared using 3 different routes of administration, i. e., intraperitoneally (IP), intramuscularly (IM) and intralabyrinthine (IL). Morphological change of the posterior canal crista was observed by SEM. The poterior canal am pullary nerve action potentials (AP) in response to 3 classes of mechanical endo- lymphatic flow were recorded. The change in AP maximum spike count was compared with SEM findings of the sensory epithelia.
SEM revealed no damage in the crista of IP-injected animals. In IM-injected animals, mild changes were found. IL injection, however, resulted in servere damage. The damage started at the portion between the center and the periphery of the ctista and developed toward the center and finally toward the periphery. The damage also progressed with the lapse of time after injection, indicating “delayed ototoxicity”. Changes in the AP were already noticed even in the animals without damage in the surface structure. Decrease in the AP maximum spike count was minimum in IP-injected animals and was maximum with IL injection. With any type of injection, the decrease in the AP tended to correlate with the degree of the damage in the sensory epithelia. The bullfrog may serve as a good model for evaluating both physiological and morphological effects of ototoxicity
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Noriyuki Fukushima
1988 Volume 1988 Issue Supplement27 Pages
17-26
Published: October 30, 1988
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Supporting cells of the guinea pig macula and thc ampullary crista were observed using TEM and SEM. Morphological structure of the macular supporting cell was basically identical to that of the ampullary crista. The reticular membrane found in the upper part of the supporting cell body consisted of aggregated intermediate filaments. The possible function of the reticular membrane is to enhance the stiffness of the supporting cell frame work, but also to play some role in maintaining the suspension of the sensory cells. Abundant granules were observed in the supporting cell and the granules were secreted from the cell surface. Structure of the granule and pattern of the secretion did not differ between the macula and the crista. Functional relationship between the granules and neighboring structure, such as the cupula or the otolithic membrane should be further studied.
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Mamoru Itoh
1988 Volume 1988 Issue Supplement27 Pages
27-36
Published: October 30, 1988
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The contours and the internal ultrastractures of the geniculate ganglion cells of the facial nerve of guinea pigs were three-dimensionally observed using a scanning electron microscope (SEM) and transmission electron microscope (TEM).
Geniculate ganglion cells are pseudounipolars. Their axions c o nvolved the cell body and flowed away from the cell body. Some of them branched of or U-turned immediately after convolving. Geniculate ganglion cells could be divided by SEM into light cells and dark cells. Light cells had well-developed intracellular organella, such as mitochondria, endoplasmic reticulum (ER), Golgi apparatus and dense body, and occupied most of the geniculate ganglion cells.
Dark cells were smaller than light cells. Lik e light cells, dark cells had well-developed intracellular organella, but most of them were occupied by stratified rough endoplasmic reticulum Mitochondria of dark cells were smaller than those of light cells and many of them were globular.
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Takako Ohya
1988 Volume 1988 Issue Supplement27 Pages
37-47
Published: October 30, 1988
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The fine structure of the vestibular ganglion of the guinea pig was studied by transmission electron microscope and scanning electron microscope. All vestibular ganglion cells were myelinated bipolar cells. The intracellular organella, Golgi apparatus, endoplasmic reticulum, mitochondria, and lysosome were clearly observed. Schwann cells were also seen.
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Mamoru Suzuki, Jack L Pulec, James C Smith
1988 Volume 1988 Issue Supplement27 Pages
48-53
Published: October 30, 1988
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Eighty nine cases of peripheral vestibular lesions were examined by the sinusoidal harmonic acceleration test, SHA, and the results were compared with caloric test abnomalities. The average phase lag of SHA decreased in the rotation to the lowest frequency (0.01 Hz), resulting in a typical “peripheral type” curve. Even the patients with a normal caloric response showed a significant decrease in the phase lag at the lowest frequency. In the rotation to 0.02 Hz, the phase lag tended to decrease according to the degree of the caloric canal paresis. The above findings indicate that SHA is more sensitive in detection of peripheral lesions than the conventional caloric test. Furthermore, SHA to 0.02 Hz appears to be useful for diagnosing more extensive vestibular lesions.
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Ototaka Kaki, Shuso Arishige, Masuhiro Noda
1988 Volume 1988 Issue Supplement27 Pages
54-58
Published: October 30, 1988
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Auditory brain-stem response (ABR) and electrocochlcography (ECoG) were recorded on II children with congenital hypothyroidism. The mean N
1latency increased and its latency-intensity (L-I) curve became steeper at a low intensity (P<0.01). The mean N
1-V interval tended to decrease and its L-I curve tended to become steeper at a low intensity. These findings suggest that the cochlear abnormality causes hearing impairment in congenital hypothyroidism.
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Yuji Watanabe, Mamoru Suzuki, Katsuhiro Hirakawa, Makoto Shirane, Yosh ...
1988 Volume 1988 Issue Supplement27 Pages
59-63
Published: October 30, 1988
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Seventeen cases (nineteen ears) of conductive hearing loss with normal tympanic membrane treated were studied. Seventeen cases were as follows: 5 cases (5 ears), incudostapedial joint dislocation; 5 cases (7 ears), congenital ossicular malformation; 6 cases (7 ears) otosclerosis.
The postoper ative hearing-gain was 23.8 dB for incudostapedial joint dislocation and 21.4 dB for congenital ossicular malformation and 22.9 dB for otosclerosis.
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Michinori Kurokawa, Akira Nagasawa, Shiroh Kajihara
1988 Volume 1988 Issue Supplement27 Pages
64-70
Published: October 30, 1988
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A 64-year-old man who developed right total cranial nerve palsies (Garcin's syndrome)during the past three years and 8 months is reported. Biopsy from the right external auditory canal revealed a squamous cell carcinoma. Intraarterial administration of cisplatinum from the maxillary artery markedly improved the symptoms both subjectively and objectively. The tumor was suspected to have originated from some area below the skull base.
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Katsuhiro Hirakawa, Mamoru Suzuki, Yoshihiko Kohno, Toshitada Sakai, Y ...
1988 Volume 1988 Issue Supplement27 Pages
71-76
Published: October 30, 1988
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Five cases of congenital stapes fixation and syndactylia or symphalangism occurring in one family are reported. Three of the five cases had syndactylia between second and third toes on both feet and one had ankylosis of the middle joint of the fifth finger of left hand. All five patients had conductive deafness. Stapes surgery was performed and satisfactory postoperative hearing was gained.
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Ototaka Kaki, Shuso Arishige, Masuhiro Noda, Hiroshi Akamizu
1988 Volume 1988 Issue Supplement27 Pages
77-82
Published: October 30, 1988
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Eosinophilic granuloma is a benign lytic lesion of bone, probably arising from an abnormal proliferation of histeocytes. A 10-year-old boy with eosinophilic granuloma of the left temporal bone is reported. An aural polyp was found along the posterior bony canal wall. The temporal lesion produced a characteristic “punchedout” radiolucent defect without surrounding sclerosis. These two characteristics are strongly suggestive of eosinophilic granuloma and allow early differentiation from cholesteatoma, acute mastoiditis and external otitis.
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Midoriko Itoh, Mamoru Itoh, Michinori Kurokawa, Takako Ohya, Koji Yaji ...
1988 Volume 1988 Issue Supplement27 Pages
83-88
Published: October 30, 1988
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A rare case of leiomyosarcoma of nasal cavity is reported. The patient was a 59-year-old woman who complained of recurrent epistaxis from the right nasal cavity. The tumor was removed by surgery. Histological examination revealed spindle-like, shaped cells which gathered together to form a corded arrangement and immunoperoxidase demonstration was positive and diagnosed as leiomyosarcoma.
The patient had no recurrence one year after the operation.
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Koji Sera, Koji Yajin, Nobuharu Tagashira, Katsuhiro Hirakawa, Yutaka ...
1988 Volume 1988 Issue Supplement27 Pages
89-96
Published: October 30, 1988
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A rare case of sigmoid colon cancer that metastasized to the maxillary sinus was reported. The patient was a 74-year-old female with complaints of left cheek swelling and pain. She had undergone an operation for adenocarcinoma of sigmoid colon four years earlier. She also had metastases to the right lung and liver. A biopsy of maxillary tumor revealed that th. e. maxillary tumor was metastatic adenocarcinoma. The patient was treated with radiotherapy, but died about 7 months later.
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
1988 Volume 1988 Issue Supplement27 Pages
97-100
Published: October 30, 1988
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A case of so-called carcinosarcoma of the right maxillary sinus is reported. The patient was a 74-year-old female with complaints of right cheek pain and hemopurulent rhinorrhea. The X-ray examinations revealed a unilateral shadow in the right maxillary sinus but no destruction of its bony wall. Caldwell-Luc antrostomy was carried out, and the polyp-like tumor in the sinus was removed. The histopathological examinations revealed that the tumor was epithelial in origin, and it was diagnosed socalled carcinosarcoma.
Following the surgery, the patient was treated by FAR therapy (5-FU, vitamin A, and radiation). There has been no evidence of disease for 8 months after the first treatment.
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Yoshihiko Kohno, Hiroyuki Takahashi, Shin-Ichi Kushida, Yasuo Harada, ...
1988 Volume 1988 Issue Supplement27 Pages
101-105
Published: October 30, 1988
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A 41-year-old man visited our clinic with the chief complaint of considerable trismus and swelling on the right parotid region following a tooth extraction. Clinical examination such as CT, MRI-CT and fine needle aspiration biopsy revealed abscess formation in the right parapharyngeal space. The patient was treated by antibiotics administration, heat therapy and draining the abscess by intraoral and extraoral incision. He was discharged on the 56th hospital day.
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Yuji Watanabe, Koji Yajin, Naoyuki Haguma, Yasuo Harada
1988 Volume 1988 Issue Supplement27 Pages
106-109
Published: October 30, 1988
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A case of chondrosarcoma in parapharyngeal space is reported. The patient was a 30-year-old man who complained of disturbance of opening mouth and tenderness from the left preauricular area to the angle of the mandible. CT revealed a tumor of left parapharyngeal space. The tumor was removed via a transparotid-cervical approach, and radiation therapy was done postoperatively.
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Wataru Tada, Yumi Fujiwara, Yoshihiko Kohno, Mamoru Suzuki, Koji Yajin ...
1988 Volume 1988 Issue Supplement27 Pages
110-114
Published: October 30, 1988
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A 57-year-old woman presented with a mass in the left upper neck and paralysis of the left XIIth cranial nerve. Sialo-CT scan showed an enhanced mass in the left parapharyngeal space. Carotid angiogram revealed that the tumor was hypervascular and that the bifurcation of the carotid artery was not widened. Surgery was performed. The tumor pushed the carotid vessels anteriorly. The vagus and hypoglossal nerves ran into the tumor, and were sacrificed; the carotid artery was preserved. Histopathological examination showed paraganglioma.
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Haruo Hirakawa, Nobuharu Tagashira, Yoshihiko Kohno, Yutaka Nagasawa, ...
1988 Volume 1988 Issue Supplement27 Pages
115-120
Published: October 30, 1988
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A case of triple squamous cell carcinomas occurring in the oral floor (T4NOMO), larynx (T4N2M0), and hard palate (T2NOMO) is reported. The patient was a 57-year-old male with complaints of hoarseness and swallowing pain. He had oral floor carcinoma and had undergone preoperative irradiation (3000 cGy) and surgery about 4 years earlier. The otorhinolaryngological examinations revealed the tumors of the left supraglottic region and hard palate. Surgery and postoperative irradiation (5040cGy) were performed. He is alive and well without evidence of disease at 20 months follow up.
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Yoshinori Sugata, Koji Yajin, Hiroyuki Takahashi, Seishi Tanaka, Yasuo ...
1988 Volume 1988 Issue Supplement27 Pages
121-125
Published: October 30, 1988
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Verrucous carcinoma is a distinct variant of well-differentiated squamous cell carcinoma. It is characterized by warty appearance, slow growth, local invasion and scarcity of metastases, and it has a typical clinical course.
A verrucous carcinoma of the hard palate and b u ccal mucosa occurring in a 68year-old woman is reported. This patient has been treated with laser surgery alone. Local recurrence developed, but after four laser surgeries there was no local recurrence and no distant metastasis.
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Akira Nagasawa, Michinori Kurokawa, Kazuko Hamanaka, Kenji Morita
1988 Volume 1988 Issue Supplement27 Pages
126-129
Published: October 30, 1988
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A 47-year-old male with secondary syphilis is reported. He had been misdiagnosed as having laryngeal carcinoma (squamous cell carcinoma) by punch out biopsy of right arytenoid.
He had no symptom of the throat, but was followed up for multiple leukoplakia of the pharynx and larynx, which was pointed out at another clinic and he recieved a biopsy. Then he was referred to our clinic for treatment. Serum syphilitic reaction at the admission revealed titers of 1: 64 by the glass plate method,1: 128 by the agglutination, and 1: 1280 by TPHA. He had no abnormality in the genitals or body surface.
Of 13 syphilis cases (J an,1985-May,1986; Onomichi General Hospital),7patients have no symptomatic. We concluded that nonsymptomatic syphilis, on the increase, should be discovered through various methods, such as pre-operative examination, other various medical examinations, and doctors' intensive observations.
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Takako Ohya, Yumi Fujiwara, Masaya Takumida, Nobuharu Tagashira, Koji ...
1988 Volume 1988 Issue Supplement27 Pages
130-135
Published: October 30, 1988
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Two cases of sebaceous carcinoma are reported. The first case (33-year-old female), was admitted for tumor formation of right parotid region to our department. At the admission she had been suffering from it for 11 years and the tumor size was 3.5 × 3.5 cm. In the operation the tumor rose from deep lobe to superficial lobe and was extirpated on March 18,1987. There is no evidence of the tumor reccurence. The second case (65-year-old female), had been suffering from right parotid tumor for 55 years and admitted us on March 1,1983. After the extirpation there is no evidence of reccurence. The pathology of these two cases is sebaceous carcinoma. A review of the literature revieled 21 cases.
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Nobuharu Tagashira, Yoshinori Sugata, Haruo Hirakawa, Yasuo Harada, Sh ...
1988 Volume 1988 Issue Supplement27 Pages
136-142
Published: October 30, 1988
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A case of primary malignant lymphoma of the thyroid is reported. The patient was a 71-year-old woman with a large tumor on the right anterior neck. Histopathological diagnosis of diffuse lymphoma, small cleaved with B-immunoblastic transformation was made. Due to the rapid enlargement of the neck lesion, chemotherapy was initiated and simultaneous radiation therapy was given to the neck and upper mediastinum. After the primary treatment, she received additional intermittent chemotherapy for 2 years and is presently asymptomatic.
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Shuso Arishige, Ototaka Kaki, Masuhiro Noda
1988 Volume 1988 Issue Supplement27 Pages
143-146
Published: October 30, 1988
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Acute suppurative thyroiditis is a rare disease. We report a case of acute suppurative thyroiditis in a 12-year-old boy. The barium meal revealed a sinus tract originating at the apex of the left piriform sinus, which indicated the possible route of infection to the thyroid.
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Shuso Arishige, Ototaka Kaki, Masuhiro Noda, Shuji Miyawaki, Ryo Omura
1988 Volume 1988 Issue Supplement27 Pages
147-155
Published: October 30, 1988
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Eleven cases of blowout fracture are reported. Eight cases were of linear type fractures and others were of punched out type. Early corrective operations with transmaxillary approach were performed. With this approach, the fracture site of the orbital floor was exposed widely and satisfactory results were obtained.
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Yumi Fujiwara, Noriyuki Fukushima, Ryo Omura, Nobuharu Tagashira, Koji ...
1988 Volume 1988 Issue Supplement27 Pages
156-163
Published: October 30, 1988
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Seventeen cases of primary paranasal cyst are reported. The patients were between fourteen and eighty-one years old, with a peak in the sixth decade. Nine were males and eight were females. Six cases were of the maxillary sinus, six others were of frontal sinus, two of ethmoid sinus and one was of sphenoid sinus. The other two cases involved both the maxillary and ethmoid sinus. The wall of the cyst consisted of inflammed mucous membrane or fibro-collagenous tissue. The epithelium was comprized of squamous cells or columnar cells and in some cases, there were no epithelium. Only three of the seventeen cases had a history of chronic sinusitis and one had allergic rhinitis, but seven other cases seemed to have inflammation in paranasal sinuses from X-ray findings.
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Eiji Sato, Koji Yajin, Yasuo Harada, Koji Sera
1988 Volume 1988 Issue Supplement27 Pages
164-169
Published: October 30, 1988
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Dental foreign bodies in the air and food passages of 17 patients were clinically analyzed.
1. In 13 cases the foreign body was in the food passage, and in the other 4 cases in the air passage.
2. The foreign body was part of the dentures in 13 cases, dental crowns in 3 cases and a dental mirror in one case.
3. The experience of 2 infantile cases suggested that deciduous teeth are recently being treated more often.
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Ryo Omura, Eiji Sato, Toshitada Sakai, Makoto Shirane, Mamoru Suzuki, ...
1988 Volume 1988 Issue Supplement27 Pages
170-182
Published: October 30, 1988
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The 240 cases of esophageal and 69 cases of tracheo-bronchial foreign bodies treated in our clinic between 1969 and 1986 were analyzed.
Most (88.3%) of the esophageal foreign bodies were in infants less than 4 years old. and adults over 40 years old, while tracheo-bronchial foreign bodies were mainly observed in infants less than 3 years old (71.0%).
The most often observed esophageal and tracheo-bronchial foreign bodies were coins (45.4%) and peanuts (34.8%), respectively. The most frequent site of lodgemen t was the cricopharyngeal portion of the esophagus and the right main bronchus.
The majority of esop h ageal foreign bodies (75.0%) and 44.9% of the tracheobronchial foreign bodies had been lodged for six hours.
Three cases of esophageal foreign bodies were treated with lateral pharyngotomy.
Twenty seven cases (39.1 % ) of tracheo-bronchial foreign bodies were removed by inferior bronchoscopy, and the others by superior or ventilation bronchoscopy.
No severe complications were observed in the case of esophageal foreign bodies, while 3 of the patients with tracheo-bronchial foreign bodies died of pneumonia or suffocation.
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Koji Yajin, Yasuo Harada, Masakaze Nakata, [in Japanese], [in Japanese ...
1988 Volume 1988 Issue Supplement27 Pages
183-188
Published: October 30, 1988
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The 489 cases of head and neck malignant tumors seen in the area of Hiroshima prefecture between 1983 and 1985 were analyzed. Of the 489 tumors,131 were in the larynx,46 in the tongue,43 in the maxillary sinus,40 each in the hypopharynx and salivary glands,35 each in the mesopharynx and thyroid gland,26 in the epipharynx,22 in the nasal, paranasal cavities except for maxillary sinus and lip, oral spaces, respectively and 46 in other organs. Of the tumors,86% were cancer,11 % malignant lymphoma,2% sarcoma and 1% malignant melanoma.
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Yutaka Nagasawa, Nobuharu Tagashira, Hironori Miyawaki, Katsuhiro Hira ...
1988 Volume 1988 Issue Supplement27 Pages
189-198
Published: October 30, 1988
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The 86 patients with tongue cancer initially treated at Hiroshima University Hospital between 1973 and 1987 were clinically studied. There were 62 males and 24 females, and t he average age of these patients was 55.2 years old. The five-year survival rate was 55.9. (Stage I: 80.3% Stage II: 66.7% Stage III: 17.8% Stage IV: 40.0%)There was no signifi c ant difference between the patients treated by radiation and those treated by surgery. Concerning th e prognosis, control of the cervical metastasis is a more important facter than that of the primary lesion.
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Katsuhiro Hirakawa, Koji Yajin, Nobuharu Tagashira, Mamoru Suzuki, Yut ...
1988 Volume 1988 Issue Supplement27 Pages
199-206
Published: October 30, 1988
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Two hundered and sixteen cases of laryngeal cancer were investigated retrospectively. There were 131 cases of glottis,73 of supraglottis and 12 of subglottis. The overall five-year survival rate was 71.6%. The five-year survival rates for stage I to IV were 96.7,62.5,65.7 and 42.1% respectively. Successful control rates of the primary tumor for Ti and T2 by radiation were 84.7% and 82.9% respectively. Distant metastases were observed in 8 cases (3.7%).
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Katsuhiro Hirakawa, Koji Yajin, Nobuharu Tagashira, Mamoru Suzuki, Yut ...
1988 Volume 1988 Issue Supplement27 Pages
207-211
Published: October 30, 1988
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Fifty eight cases of maxillary carcinoma were treated at Hiroshima University Hospital between 1978 and 1987. There were 40 males and 18 females. The majority of the patients were over 50 years old.
The three-year and five-year survival rates of all the patients were 55.4 and 47.7%, respectively, and that of those treated with combined therapy consisting of local chemotherapy (5 FU continuous, ADM bolus), radiation and necrotomy following radical surgery were 71.9 and 61.3% respectively.
Local recurrence and distan t metastasis were the main cause of death. The rate of distant metastasis was higher in the group treated by radical surgery than that treated without surgery.
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Nobuharu Tagashira, Yuji Watanabe, Ryo Omura, Hiroyuki Takahashi, Yasu ...
1988 Volume 1988 Issue Supplement27 Pages
212-217
Published: October 30, 1988
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Thirty-one cases of carcinoma of the hypopharynx treated between 1970 and 1983were investigated retrospectively. The carcinoma was in the piriform sinus in 17 cases, postcricoid in 10, and posterior pharyngeal wall in 4 cases. The stage II and III occupied 74.5% of all cases, and were particularly more frequent in postcricoid carcinoma. The rate of cervical lymph node metastasis in postcricoid carcinoma was high. The group treated by surgery had a higher five-year survival rate than the nonsurgery group, and the group treated with combined therapy of irradiation and surgery had a higher five-year survival rate than the group of surgery alone. The surgical treatment applied in the 17 cases was pharyngolaryngotomy in 3, pharyngolaryngoesophagotomy in 13, partial resection of pharynx in 1. The five-year survival rate for all the patients was 40.4%.
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Hiroyuki Takahashi, Yoshinori Sugata, Yuji Watanabe, Katsuhiro Hirakaw ...
1988 Volume 1988 Issue Supplement27 Pages
218-222
Published: October 30, 1988
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Ten cases of parapharyngeal space tumor treated between 1977 and 1987 were clinically studied. All tumors were removed surgically. Various approaches were used; peroral excision, cervical approach, transparotid-cervical approach, and combined approach. Histopathological diagnosis was schwannomas in two, pleomorphic adenoma in two, meningioma, paraganglioma, adenocarcinoma, metastatic carcinoma of unknown origin, chondrosarcoma, and carcinoma in pleomoric adenoma in one case each.
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Makoto Shirane, Koji Yajin, Katsuhiro Hirakawa, Yasuo Harada, Yumi Fuj ...
1988 Volume 1988 Issue Supplement27 Pages
223-236
Published: October 30, 1988
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The 142 cases of salivary gland tumors treated in our department during the past ten years were reviewed clinicopathologically. Major salivary gland tumors were found in 124 cases with 110 cases of parotid tumors and 14 cases of submandibular gland tumors. Minor salivary gland tumors were found in only 18 cases. Pleomorphic adenoma was the most predominant tumor in the salivary glands accounting for 59%of all cases. There were malignant tumors in 15% and 56% of major and minor salivary glands respectively, indicating the high incidence of malignancy in the minor salivary gland. Among the malignant tumors of the minor salivary were 3 gland cases of adenoid cystic carcinoma which was found only in one case of the major salivary gland. Compared to the benign tumors, more malignant tumors which were larger were found in elderly males. Malignant tumors were accompanied by facial palsy and pain with a high incidence only in the parotid gland. In the submandibular and minor salivary glands, the small number of cases did not reveal any differences in rates of these complications.
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Yoshihiko Kohno, Koji Yajin, Koji Sera, Takako Ohya, Haruo Hirakawa, Y ...
1988 Volume 1988 Issue Supplement27 Pages
237-247
Published: October 30, 1988
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A clinical study was done on 55 patients with head and neck malignant lymphomas treated during the past 12 years.
Of 55 cases 3 were diag n osed as Hodgkin's disease and the others were diagnosed as non-Hodgkin's lymphoma (NHL) histopathologically.
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