To verify the concordance between the clinical and histopathological diagnosis of OLP, we examined the clinical and histopathological findings and the potential presence of lichenoid lesions in patients presenting with OLP. We conducted a review of the histopathological findings in 60 patients who had been clinically diagnosed as having OLP. Based on this review, 50% of the cases had pathologically confirmed OLP (pOLP), 43% had pathologically suspected OLP (pOLPsus.), and the remaining 7% had other diseases. Cases of pOLPsus. were commonly associated with erosion or ulceration, but not definitely associated with the following characteristic features of OLP: sign of “liquefaction degeneration” in the basal cell layer; and Civatte body formation. Histopathological features of OLP did not correlate with metal allergy or underlying disease examined in the present study. These findings indicate that the pathological diagnosis of clinically diagnosed erosive OLP is difficult.

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In Candida associated denture stomatitis, dentures may serve as reservoirs of Candida species and relapses may occur when adequate management of dentures is not achieved. The purpose of this study is to examine oral Candida species colonization on denture surface in denture wearers and to elucidate the anti-fungal effect of ozonated water.
Fungal cultures from denture surfaces were performed from 248 dentures of 149 patients with suspected Candida stomatitis, and 168 dentures (68%) were positive for Candida culture. Candida albicans was the most prevalent species; it was isolated from 55% of positive dentures. Candida glabrata was the next most prevalent (37%). Many C.glabrata were found in combination with C.albicans. One hundred twenty dentures were treated with ozonated water at 4 ppm in combination with ultrasonication for 10 minutes. This treatment resulted in significant reduction in the number of Candida species. Mixed C.albicans + C.glabrata responded significantly poorer to ozonated water than did single species C.albicans.
In conclusion, C.glabrata is frequently isolated from acrylic denture surfaces of denture wearers. Ozonated water is effective in reducing the number of Candida species on dentures. Mixed C.albicans + C.glabrata demonstrated more resistance to ozonated water than single C.albicans.

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We report two cases of cheilitis granulomatosa (CG) successfully treated by removal of infectious foci of apical periodontitis. Case 1: The patient was a 70-year-old man who complained of swelling of the lower lip one month earlier. Biopsy specimens showed granulomatous change including multinucleic giant (Langhans giant cell) cells, and diagnosed as CG. Case 2: The patient was a 41-year-old woman who complained of swelling of the lower lip two months prior to her first visit. Biopsy specimens showed granuloma with epithelioid cells, and diagnosed as CG. Panoramic X-rays of these two patients revealed a periapical radiolucency of the left mandibular first molar. Both of these cases were underwent extraction of the left mandibular first molar. Swelling of the lower lip was gradually regressed within three months after the tooth extractions. Dental focal infection was thus considered as a cause of CG in these patients.

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