A six-year-old, male Pomeranian showed symmetric pigmented alopecia on the trunk and caudal femoral regions which had developed at three years of age without any systemic signs for metabolic disorders. A hemogram, biochemical analysis, and ACTH stimulation test did not show any apparent abnormalities. The dog failed to demonstrate suppression of cortisol with low-dose dexamethasone, and an MRI scanning did not reveal apparent adrenal gland enlargement. The dog was diagnosed as adrenal sex hormone imbalance. Alopecia had not been ameliorated by administration of L-cysteine, Vitamin E-niacinamide, and sex normonal agents. Hair regrowth, however, was recognized after the onset of coincidental generalized pyoderma and flea infestation, and complete hair coat was observed 5 months later.