An 11-year-old female Beagle presented with clinical and laboratory findings consistent with Cushing's syndrome. ACTH stimulation test as well as low and high-dose dexamethasone suppression tests did not reveal any abnormalities. X-ray and ultrasonography showed bilateral calcification of the adrenal glands and MRI scan showed a mass on each side of them. Clinical and laboratory conditions improved spontaneously without any treatment, although previously existing diabetes mellitus required continuous therapy.

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A 4-year-old spayed female Boxer presented with a 1-month-history of pigmented alopecia at the bilateral flank in January. Histopathology of the skin lesion revealed dilation of the follicular infundibula with hyperkeratosis and epidermal hyperpigmentation. Complete blood count, blood chemistry analyses, TSH stimulation test, and ACTH stimulation test did not show any abnormalities. The dog was diagnosed as seasonal flank alopecia, and improved spontaneously without any treatment in June. The lesion was reproduced clinically and histopathologically when the dog was kept in a dark room for one month during summer season. It was demonstrated that environmental factors play an important role for the onset of the disease.

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