Fluorine-18 was prepared by neutron irradiation of lithium carbonate in the reactor JRR-1. Five grams of lithium carbonate was irradiated for 2 hr with a thermal neutron flux of 6×10
11 n/cm
2/ sec. An alumina column was used to separate
18F from the irradiated material. The various factors which affect the separation were studied, and purity and specific activity were determined. About 90μc of
18F per gram of lithium carbonate was prepared by this method with a chemical yield exceeding 80%. The prepared
18F was pure enough radiochemically but contained a small amount of lithium and aluminum. The specific activity was about 0.5 mc/mgF.
The chemical form of the 18F obtained by the above method was studied by paper-chromatography. A sample was developed on filter paper by the ascending method using butanol-methanol-water mixture as solvent, and the distribution of
18F radioactivity was determined. From the results of the paper-chromatographic study, it was found that most of the
18F existed in the form of fluoride but about 16% in other form possibly a complex with aluminum.
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