Purpose To clarify the rate of posterior residual ridge resorption (PRRR) in different denture treatments and the factors that can affect PRRR.

Study selection A bibliographical electronic search was conducted on MeSH, Web of Science, and Ovid databases. Hand searching was also conducted. Longitudinal studies recording the average rate of PRRR in the mandible were included. The effect size was calculated based on the mean rate of PRRR with standard deviation and group size. The random-effects analysis was used to perform meta-analyses across qualified studies.

Results A total of 2245 eligible studies were collected from the MeSH, Web of Science, and Ovid databases and hand searching. In the end, 19 studies met the inclusion criteria and were extracted. The average rate of PRRR in different mandibular denture treatments was assessed in this systematic review. The mean combined effect size was -1.05 ± 0.5 (95% confidence interval [CI]: -3.18–1.08) between four-implant overdentures and two-implant overdentures. The combined effect size was -0.01 ± 0.22 (95% CI: -0.93–0.82) between complete dentures and two-implant overdentures. Body mass index, number of dentures used, denture wearing habit, impression technique, artificial tooth material, and peri-implant bone resorption showed no significant effect on the rate of PRRR. Gender, denture material, and relining frequency showed a significant effect on the rate of PRRR.

Conclusions This review summarized different average rates of PRRR in mandibular denture treatments. Meta-analyses have reported that four-implant overdenture treatments can lower the rate of PRRR compared to two-implant overdenture treatments. However, there was no significant difference in the treatment effect between the complete denture and two-implant overdenture treatments.

Purpose The state of adhesion between root dentin and a resin composite core material was inspected using acoustic emission (AE).

Methods A total of 14 human incisors and premolars were used to prepare "no-adhesive group" and "adhesive group" specimens. For "adhesive group" specimens, a bonding agent was applied to root canal dentin. The entire post space was subsequently filled with a resin composite for both specimen groups. The prepared specimens were fixed onto a jig on which an AE sensor was installed. A zirconia ball was used for the impact test, and a vibration wave generated by the collision was measured by the system using an AE sensor. The obtained data were subjected to time–frequency analysis using analysis software (LabVIEW), and the relationship between the amplitude indicating the loudness and the frequency indicating the sound component was analyzed.

Results Zirconia-ball collision tests using AE revealed differences between the groups with respect to the waveform of vibration waves transmitted to the root dentin through the root dentin–resin interface. The time–frequency analysis of the obtained data confirmed that multiple peaks were observed for each specimen in the no-adhesive group, whereas a single characteristic vibration peak was observed for all specimens in the adhesive group.

Conclusions The state of the adhesive interface was successfully evaluated by AE. This demonstration is expected to lead to the development of a device that can detect problems at the bonding interface between the prostheses and tooth substances.

Purpose To evaluate the effect of different cleaning methods on the shear bond strength (SBS) of a 10-methacryloyloxydecyl dihydrogen phosphate (MDP)-containing self-adhesive resin cement to zirconia after saliva contamination.

Methods Sixty zirconia specimens were randomly divided into four groups (n=15) according to treatment surface. Except for the control group, all samples were contaminated with saliva and were then rinsed with water-spray and air-dried. Subsequently, the specimens were either treated with a cleaning paste (CP), with argon plasma (AP), or did not undergo an additional cleaning process (WS). An MDP-containing self-adhesive resin cement was applied onto the ceramic surfaces. Specimens were stored in water (24 hours) followed by thermocycling (5°C to 55°C for 10.000 cycles). SBS tests were performed in a universal testing machine, and the results (MPa ± SD) were statistically analyzed using ANOVA and Bonferroni post-hoc test. Fractured surfaces were examined to identify the failure types using a stereomicroscopy and SEM.

Results The surface cleaning treatment (p<0.05) significantly affected the results. The highest SBS values were observed in the control group (12.16 ± 1.22 MPa) and were statistically comparable to values for the CP group (11.38 ± 1.65 MPa). The AP group (9.17 ± 1.06 MPa) showed significantly higher bond strength than the WS group (6.95 ± 1.20 MPa), but it showed significantly lower strength than the control and CP groups.

Conclusions The CP application was the most effective method in removing saliva contamination. The AP treatment could not restore the SBS to the same level as uncontaminated specimens.

Purpose Although oral functions have been evaluated by various methods in maxillectomy patients, there exists substantial difficulty in the assessment procedures. The purpose of this study was to evaluate masticatory function, maximum occlusal force (MOF), and maximum tongue pressure (MTP) in maxillectomy patients objectively as per the "oral hypofunction" criteria, and examine the factors that correlate with masticatory function.

Methods This retrospective cross-sectional study included 50 maxillectomy patients with maxillofacial prostheses (23 males and 27 females, median age, 72 years; interquartile range (IQR), 63.75–77). The records of masticatory function, MOF, and MTP as per the "oral hypofunction" criteria and their profiles (age, number of occlusal supports, and maxillary defect configuration) were reviewed. The number of patients who exceeded a threshold value of "oral hypofunction" and the effects of occlusal support and defect configuration on masticatory function and MOF were calculated. Multiple regression analysis was performed to assess the associations between masticatory function and other variables.

Results The median value of masticatory function (114 mg/dL, IQR: 73–167.5) exceeded a threshold value, but not MOF (229.2 N, IQR: 110.2–419.6) and MTP (25.9 kPa, IQR: 21.4–29.0). The number of patients who exceeded each threshold value was 27 (masticatory function), 8 (MOF), and 12 (MTP), respectively. The influence of the number of occlusal supports, but not the defect configuration, was statistically significant. Multiple regression analysis revealed that MOF was independently related to masticatory function (P=0.042).

Conclusions Within the limitations of this study, the median value of masticatory function in maxillectomy patients could exceed a threshold and MOF might be an independent predictor of masticatory function.

Purpose The aim of this study was to evaluate the stability of single crowns and 3-unit bridges in relation to the implant-abutment complex with and without tube in tube connection.

Methods 60 specimens with a total of 90 implants (diameter 3.8 mm) were fabricated and distributed into 4 groups: CST (Crown with short tube), CLT (crown with long tube), BNT (Bridge without tube) and BLT (bridge with long tube). All superstructures consisted of one-piece hybrid abutment restorations out of monolithic zirconia, bonded on prefabricated titanium bases and were directly screwed into the implants. Specimen underwent artificial aging (2.000.000 cycles, 120 N, 30° off axis) and were subsequently loaded in an universal testing machine at an angle of 30° until failure. The specimens were examined for damage during and after artificial aging.

Results During artificial aging, one test specimen of group CLT and two test specimens of group BNT failed. The average failure load was 498.8 (± 34.4) N for CLT, 418.8 (± 41.5) N for CST, 933.1 (± 26.2) N for BLT and 634.4 (± 29.0) N for BNT, with a statistical differences (p ˂ 0.001) between the crown and bridge groups. All tested samples exhibited macroscopic deformations at the implant shoulder, which were more pronounced in the specimens without a tube in tube connection.

Conclusions Single crowns and 3-unit bridges with a long tube in tube connection showed significantly higher fatigue fracture strength compared to restorations with short or without tube in tube connection.

Purpose To investigate the accuracy of implant-supported connecting crowns fabricated with digital definitive casts and conventional definitive casts.

Methods Using a master model with two implant bodies inserted into the right mandibular molar area, 10 digital definitive casts were fabricated. Additionally, 10 conventional definitive casts were fabricated. The distance and angle between the two abutments of each definitive cast were compared. To compare the amount of lift of the incisal pin, each of the 10 superstructures was fabricated via computer-aided design/computer-aided manufacturing and then returned to the master model.

Results No significant difference was observed for either the angle or the distance between the two abutments. The amount of lift of the incisal pin when the superstructure obtained via the optical method was returned to the master model was significantly larger than that when the superstructure obtained via the conventional method was returned to the definitive cast and the master model. No significant difference was observed after occlusal adjustment of the superstructures obtained using the conventional method.

Conclusions The precision of definitive casts obtained via the optical method was virtually equal to that of definitive casts obtained via the conventional method. The accuracy of implant-supported connecting crowns fabricated using the optical method was significantly lower than that of implant-supported connecting crowns fabricated using the conventional method. This is attributed to the alignment of the maxillary and mandibular digital definitive casts.

Purpose This cross-sectional study compared gait performance between community-dwelling older adults with and without accumulated deficits in oral health, defined as oral frailty.

Methods A total of 1,082 individuals (439 men and 643 women; mean age, 77.1 years) from the Takashimadaira study were included in the current analysis. Based on a multifaceted oral health assessment, oral frailty was defined as having three or more of the following six components: (i) fewer teeth, (ii) low masticatory performance, (iii) low articulatory oral motor skills, (iv) low tongue pressure, (v) difficulties in eating, and (vi) swallowing. Eight gait parameters were assessed using an electronic walkway. Gait characteristics comparison between groups with and without oral frailty was performed using multiple linear regression models. Models were adjusted for age, sex, educational status, income, smoking, drinking, physical activity level, height, body mass index, comorbidities, and the presence of chronic pain.

Results Oral frailty was observed in 227 (21.0%) participants. After adjusting for potential confounders, the participants with oral frailty had slower gait speed, shorter stride and step length, wider step width, and longer double support duration as well as higher variability of stride length and step length.

Conclusions Oral frailty was associated with poor gait performance among community-dwelling older adults.

Purpose Implants made of anodized-hydrothermally treated commercially pure titanium with a nanotopographic surface structure (SA-treated c.p.Ti) may advantageously promote contact osteogenesis during the early stages of healing. We hypothesized that utilizing SA-treated c.p.Ti with dental pulp stem cells (DPSCs) might improve osteoconduction during the process of osseointegration. This in vitro study investigated the effect of initial adhesion of DPSCs to SA-treated c.p.Ti compared with conventional c.p.Ti and anodic oxide (AO) c.p.Ti.

Methods DPSCs were obtained from the mandibular incisors of Sprague-Dawley rats and cultured without osteogenic induction medium on c.p.Ti, AO c.p.Ti, and SA-treated c.p.Ti disks for up to 14 days. The morphology, proliferation, and differentiation of DPSCs were assessed by scanning electron microscopy, an MTT assay, and Alizarin Red S staining, respectively. A real-time quantitative polymerase chain reaction was used to quantify the mRNA expression of osteocalcin, osteopontin, and bone sialoprotein.

Results On all disks, the DPSCs appeared flattened with the formation of extensions over time. The filopodium-like extensions were closely bound to the SA-treated c.p.Ti surface. The proliferation of DPSCs was not significantly different among the c.p.Ti treatments. However, DPSCs on SA-treated c.p.Ti showed the greatest mRNA levels of osteopontin, osteocalcin, and bone sialoprotein, as well as increased Alizarin Red S staining.

Conclusions The results of the present in vitro study demonstrate that the surface properties of SA-treated c.p.Ti disks enhance osteogenic differentiation of DPSCs and may facilitate mineralized matrix formation on SA-treated c.p.Ti implant surfaces, which can enhance early bone regeneration.

Purpose To reveal effects of improvement of masseter muscle activity on brain function in elderly people wearing complete dentures.

Methods Subjects were 14 edentulous patients with a chief complaint of the inconvenience of their complete dentures. The surface electromyographic (EMG) activity of the masseter muscles was measured. Brain activities were analyzed with functional magnetic resonance imaging (fMRI), employing chewing gum as the task program. Cognitive functions were evaluated with Trail Making Test Part A (TMT-A), Rey Auditory Verbal Learning Test (RAVLT) and Rey-Osterrieth Complex Figure Test (R-OCFT). Those evaluations were performed in which subjects wore their old dentures (OD) or newly fabricated dentures (ND).

Results We compared ND condition with OD condition. The masseter muscle activity significantly increased in ND condition (p < 0.05, Wilcoxon signed rank test). The brain activity increased significantly in the superior frontal gyrus, precentral gyrus, putamen, inferior parietal lobule, cerebellum, inferior frontal lobe, and middle frontal gyrus under the ND condition than under the OD condition (p < 0.01, uncorrected, cluster size > 10 voxels). Results of TMT-A, RAVLT, and R-OCFT were also significantly improved (p < 0.05, Wilcoxon signed rank test).

Conclusions In the edentulous elderly, the brain activity was increased following the improvement of the masseter muscle activity. Consequently, it is possible that the improvement of the masseter muscle activity might influence on the attention, verbal skills, and visual memory.

Purpose This in vitro study aimed to evaluate the effectiveness of a sealing agent in sealing the abutment/implant interface and the preload maintenance of retaining screws after mechanical cycling.

Methods Six groups (n = 12) were evaluated according to the abutment/implant system (external-hexagon implant and UCLA abutments, EHU; Morse taper implant and UCLA abutments, MTU; and Morse taper implant and flexcone abutments, MTF) and the presence of an anaerobic gel sealing agent (control group, no sealing agent; experimental group, sealing agent). Toluidine blue (0.7 μL) was inserted into each implant and the abutments were attached to the implants using a digital torque wrench to evaluate the sealing of the abutment/implant interface. The specimens were tested through mechanical cycling (1 × 10⁶ cycles, 2 Hz, and 130 N). Dye release from the abutment/implant interface was analyzed using a spectrophotometer, and the reverse torque values were obtained using a digital wrench. Reverse torque and dye release data were measured after mechanical cycling and analyzed using ANOVA and Tukey's test (α =.05).

Results All experimental groups showed higher reverse torque values than the control groups (P <.05). In general, the MTU and MTF experimental groups, as well as the MTF control group, showed no significant dye release at different periods (P >.05).

Conclusions The use of a sealing agent improved the preload maintenance of screw-retained implant-supported prostheses. The sealing agent was effective in sealing the Morse taper connection.

Purpose The aim of this study was to examine the responsiveness of chewing tests after removable partial denture (RPD) treatment in this prospective cohort study.

Methods Pre- and post-RPD treatment, objective masticatory function was evaluated in 248 patients via chewing tests involving peanuts, a gummy jelly, and a color-changeable gum. A statistical comparison was performed between the pre- and post-treatment scores, and the standardized response mean (SRM) was determined as the treatment effect size (ES).

Results After RPD treatment, the median particle size in the sieving method using peanuts significantly decreased, and the glucose concentration in the gummy jelly method significantly increased (P < 0.001). The ESs of the sieving and gummy jelly methods were larger (|SRM| = 0.3–0.4) than that of the gum method (|SRM| = 0.1). In the subgroup analysis, the sieving and gummy jelly methods resulted in a broader effective range (|SRM| ≥ 0.3) than the gum method. In patients without pre-treatment dentures, the ES was medium in the sieving method (|SRM| = 0.6) and weak in the gummy jelly and gum methods (|SRM| = 0.3–0.4). The pre-treatment level of masticatory function was significantly correlated with ES (ρ = 0.93, P < 0.001).

Conclusions These results suggest that the sieving and gummy jelly methods are more responsive than the gum method for RPD treatment and that the pre-treatment scores affect the responsiveness.

Purpose To test if resin CAD/CAM materials should be considered for zirconia implants and how their mechanical properties affect the fracture load.

Methods Fracture load of molar crowns of CAD/CAM materials (VITA CAD-Temp [CT], Cerasmart [CS], Lava Ultimate [LU], Pekkton Ivory [PK]) on zirconia implants (ceramic.implant, 4.0 mm) fixed either with no cement, temporary cement (Harvard Implant semi-permanent [HIS]), self-adhesive (VITA Adiva S-Cem [VAS]) or either one of two adhesive cements (Multilink Automix [MLA], VITA Adiva F-Cem [VAF]) was analyzed. The restorative materials were characterized by their flexural strength, fracture toughness, elemental composition and organic/inorganic ratio while compressive strength of the cements was measured.

Results For the fracture load significantly highest mean values were found overall for PK (2921 ±300 N) > LU (2017 ±499 N) > CS (1463 ±367 N) = CT (1451 ±327 N) (p > 0.05). When analyzing the effect of the cement on the fracture load the overall ranking was VAF (2245 ±650 N) ≥ MLA (2188 ±708 N) ≥ VAS (2017 ±563 N) > HIS (1757 ±668 N) = no cement (1595 ±757 N) (p <0.05), meaning fracture load increased with the compressive strength of the cements. Additionally, a linear trend was found between the fracture load and the fracture toughness of the restorative materials.

Conclusions All restorative materials exhibited fracture load values similar or higher than lithium disilicate tested previously. Fracture load of CT, CS and LU can be significantly increased when an adhesive cement with a high compressive strength is used.

Purpose This study aimed to evaluate the effects of degradation on the strength of computer-aided design/computer-aided manufacturing (CAD/CAM) resin composite blocks (RCBs) by subjecting them to accelerated degradation in water and conducting biaxial flexural strength tests.

Methods Six commercial RCBs were tested. The RCBs were cut into disks, after which the disks were immersed in purified water. For the aging experiment, the samples were subjected to heat treatment at 37, 60, 70, and 80 °C, in a constant temperature oven and stored statically for 30 d. After the aging experiment, the elements released from the RCB fillers were measured by inductively coupled plasma atomic emission spectroscopy. In addition, the biaxial flexural strength of the RCB fillers was measured after accelerated degradation at 70 °C.

Results Si (the main component of the filler) was detected in all the RCB solutions after the aging experiment; however, the type and amount of other elements differed considerably among the RCBs. The flexural strength of some of the RCBs decreased by approximately 20–40% after the accelerated degradation. For most materials, the Weibull coefficient decreased or remained unchanged after the test, whereas it increased in some materials.

Conclusions The strength of all the RCBs decreased after the accelerated degradation tests; however, this behavior differed among the materials. In addition, the release of elements from the filler of some of the materials into the water correlated with the decrease in the strength of these materials. These findings indicate that the evaluation of the degradation behavior of RCBs in water is essential for their long-term usage.

Purpose The purpose of this study was to evaluate the long-term color stability of light-polymerized resin luting agents stored in different beverages.

Methods Eleven shades of two light-polymerized resin luting agents, Choice2 (A1, A2, B1, TRANSLUCENT, MILKY OPAQUE, and MILKY BRIGHT) and BeautiCem Veneer (H-Value, M-Value, L-Value, Ivory-D, Ivory-L) were selected in this study. Disk-shaped specimens were fabricated with 1.3 mm thickness and 15.0 mm diameter. A total of 198 specimens, 18 for each shade, were prepared and randomly divided into six storage conditions (purified water, coffee, cola, tea, red wine, and air). All shades of specimens were three times measured at three random locations (n = 9) at 24 h storage in air after specimen preparation and then measured after immersion at 1, 3, 6, 9, and 12 mos. using a colorimeter. Then, the color difference (ΔE) between the specimens at 24 h after preparation and after storage in each liquid for 12 mos. was calculated. Statistical analysis was performed using Steele–Dwass multiple comparison test of the ΔE values or one-way ANOVA and Tukey's honest significant difference test.

Results For all immersion conditions, ΔE was significantly higher than air (control). The ΔE of the shades in the various storage conditions showed no significant difference between Purified Water-Cola and Coffee-Tea. Comparisons of the color components L*, a*, and b* for each shade showed different behaviors among the shades.

Conclusions The results suggest that the color stability of light-polymerized resin luting agents may differ between different shades and beverages.

Purpose The aim of this study was to clarify the effects of different bonding systems (BSs) with various polymerization modes and root canal regions on the bond strength of core build-up resin composite to dentin.

Methods Post cavities were prepared in the roots of 54 bovine teeth. Three types of BS with various polymerization modes (light, chemical, and dual-cure) were applied to the walls of the cavities, which were subsequently filled with core build-up resin composite, and stored in 37°C water for 7 days. Each tooth was then sectioned perpendicular to the long axis of the tooth into 9-disk from the coronal to the apical side. Bond strengths were measured on two-thirds of the disks, while dye penetration was examined in the remaining third.

Results Statistical analysis revealed significant differences between the bond strengths of BSs with different polymerization modes, indicating chemical-cured BS had higher bond strength than light-cured BS. The chemical-cured BS group showed cohesive failure in both resin composite and dentin regardless of the root canal region, while adhesive failure was observed in the coronal region for dual-cured BS and in the apical region for light-cured BS. Dye penetration was significantly more at the bonding interface at the apical region of the light-cured BS.

Conclusions Chemical-cured BS displayed a greater bond strength than light-cured BS. Cohesive failure was observed in both core build-up resin and dentin, indicating that the integration of tooth structure with resin composite was effective for retaining the resin core and sealing the root canal.

Purpose Under thin, partial coverage restoration the proper cement thickness to be clinically employed still remains an issue. The aim of this study was to determine the failure and success rates of simplified lithium disilicate occlusal veneers as a function of cement thickness. The null hypothesis was that cement thickness has no effect on the fatigue resistance.

Methods Sound human molars were severed in a plane parallel to the occlusal surface to create a flat dentin surface surrounded by enamel edges. Forty-five occlusal veneers 1.0 mm thick (IPS e.max CAD LT) were luted to the teeth with Multilink Automix resin cement, creating 3 experimental groups (n=15) with cement thicknesses of 50, 100, and 200 µm. The restorations were fatigue-cycled using a ball mill machine containing zirconia and stainless steel spheres. Twelve 60 min cycles were performed. Survival statistics were applied to "failure" and "success" events, comparing the three groups using a log-rank Mantel–Cox test and a log-rank test for trends (alpha = 0.05).

Results The failure and success rates were not significantly influenced by cement thickness (P = 0.137 and P = 0.872, respectively); thus, the null hypothesis was accepted. However, when log-rank test for trends was applied to failure events, the tendency to have less failures with increasing thicknesses was found statistically significant (P = 0.047).

Conclusions The cement thickness within the range adopted here did not have a significant effect on the failure or success rate of lithium disilicate occlusal veneers when exposed to randomized impact stresses generating fatigue phenomena.

Purpose The aim of this study was to evaluate patients' economic preferences for two different tooth replacement strategies for the edentulous mandible namely conventional complete dentures (CCDs) and implant overdentures supported by two implants (IODs), using a willingness-to-pay (WTP) analysis.

Methods Twenty-six elderly patients who had been rehabilitated with either a mandibular CCD or IOD were invited to participate in this study. All participants were provided with the details of the two treatment protocols, including advantages, disadvantages, and treatment costs. The patients were then asked to indicate their maximum WTP values for each protocol using a payment card method for contingency evaluation.

Results Fifteen patients with mandibular CCD (CCD-Group) and 12 patients with IOD (IOD-Group) participated in the study. Overall, the median and maximum WTP values recorded for IOD therapy were significantly higher than those for CCD therapy (p<0.05). Both treatment groups recorded maximum WTP values for CCD therapy, which exceeded the market cost (¥30,000 [US$280]), CCD-Group: ¥50,000 (interquartile range [IQR]: 40,000 – 65,000), and IOD-Group: ¥45,000 (IQR: 30,000–85,000)]. However, both groups registered a median and maximum WTP values for IOD therapy lower than the market cost (¥780,000 [US$7,300]), (CCD-Group: ¥500,000 [IQR: 300,000 - 750,000], IOD-Group: ¥700,000 [IQR: 500,000–800,000]).

Conclusion The maximum WTP values recorded for IOD therapy were significantly higher than CCD therapy in both treatment groups. While patients were willing to pay more than the current market costs for CCDs, they were not willing to meet the market value for IODs.

Purpose This study aimed to determine the influence of mandibular free-end partial edentulism and use of conventional or implant-supported removable dental prostheses in the partially edentulous area on the load exerted on the maxillary anterior teeth.

Methods A jaw model with mandibular free-end missing teeth was used, and a distal extension, removable partial dental prosthesis was fabricated to replace the missing posterior teeth. Four experimental conditions were set up: 1) without prosthesis, 2) with a conventional removable partial dental prosthesis, 3) with an implant-supported removable partial dental prosthesis, and 4) with a complete dental arch. Strain gauges were attached to the root surface of the maxillary left central incisor, canine, first premolar, and first molar. The load exerted on them was calculated based on the calibration coefficient. An occlusal load of 49 N was applied, and the forces were compared using a Kruskal-Wallis test (P < 0.05).

Results The load exerted on the maxillary anterior teeth increased significantly with no prosthesis, decreased significantly with a conventional removable partial dental prosthesis, and decreased even more significantly with an implant-supported removable partial dental prosthesis.

Conclusions The burden on the maxillary anterior teeth decreased with the use of a removable partial dental prosthesis and decreased even further with the use of an implant-supported dental prosthesis. The use of an implant to support a distal extension removable partial dental prosthesis is potentially effective in preserving the remaining teeth and tissues by reducing excessive stress in patients with mandibular free-end partial edentulism.

Purpose The aim of the present study was to investigate the effects of chemotherapeutic/bisphosphonate combination therapy with tooth extraction on gene expression patterns of fresh extraction wounds during initial stages prior to their diagnosis as bisphosphonate-related osteonecrosis of the jaw (BRONJ)-like lesions in mice.

Methods Female C57BL/6J mice were used. To create a high-prevalence BRONJ mouse model, combination therapy with the chemotherapy drug cyclophosphamide (CY) and zoledronic acid (ZA) was performed (CY/ZA). Both maxillary first molars were extracted 3 weeks after drug therapy. Saline was used as the control (VC). Soft tissues near the fresh extraction wounds were dissected at 72 h postextraction to investigate the gene expression patterns. Maxillae and long bones at 2 and 4 weeks postextraction were also analyzed.

Results CY/ZA significantly increased the relative expression levels of IL-6 and decreased those of IL-10 and IGF-1 when compared with those in VC. Moreover, CY/ZA significantly reduced the relative expression levels of CCR-7, cxcl12, cxcr4, and CD105 when compared with those in VC, whereas the level of F4/80 was significantly increased by CY/ZA. Furthermore, CY/ZA significantly decreased the relative expression levels of VEGFA, VEGFB, and VEGFC at 72 h postextraction compared with those in VC.

Conclusions Considering that the present study lacked adequate in vitro models, CY/ZA markedly changed the gene expression patterns associated with wound healing from the initial stages prior to onset of BRONJ-like lesions, which may help us to understand the pathophysiology of BRONJ in humans.

Purpose Implant-assisted removable partial dentures (IARPDs) with short implants improve the oral functions of removable partial dentures (RPDs). This study aimed to compare the patient-reported outcomes of RPDs and IARPDs with short implants retained by magnetic attachments.

Methods We recruited 30 participants with mandibular Kennedy Class I or II and distal extension defects of three or more teeth. RPDs, IARPDs with a healing cap, and IARPDs with a magnetic attachment were evaluated across stages using patient-reported outcomes. All participants completed questionnaires (oral health-related quality of life [OHRQoL], patient general satisfaction, and patient's denture assessment [PDA]) at each stage. The OHRQoL was evaluated using the Oral Health Impact Profile-J 54 (OHIP-J 54) score. The general patient satisfaction was evaluated using a 100 mm visual analog scale. The Wilcoxon signed-rank test and Bonferroni correction were used to evaluate differences between the groups (α=0.05).

Results The OHRQoL of IARPDs was significantly higher than that of RPDs. IARPDs with a magnetic attachment had significantly better patient general satisfaction and PDA than IARPDs with a healing cap.

Conclusions The OHRQoL, patient general satisfaction, and PDA were improved by IARPD with a short implant using a magnetic attachment.

Purpose The trueness and fitting accuracy of complete dentures (CDs) manufactured digitally from wax dentures have not been investigated yet. This study evaluated the trueness and fitting accuracy of maxillary CDs manufactured using computer-aided design technology.

Methods CD bases were manufactured from fully edentulous maxillary casts using a milling machine and three three-dimensional (3D) printers (two stereolithography apparatus (SLA) and one digital light processing (DLP)). 3D printing was performed using an SLA printer with eight build support angles (0° to 315°). As a control, a CD base was conventionally fabricated using a heat-polymerized PMMA resin. After the tissue surfaces of the casts and the cameo surfaces of all the CD bases were scanned, their STL data were superimposed with a best-fit alignment. The deviations of all the CD bases were evaluated using data-matching software.

Results The milled CD bases showed higher trueness and fitting accuracy compared with the 3D-printed and conventional bases. SLA showed a higher fitting accuracy than DLP. The best support angles for the fitting accuracy were 45° and 225°. The fitting accuracy of the SLA 3D-printed CD bases with an angle of 45° was comparable to or slightly higher than that of conventionally fabricated bases.

Conclusions The milled CD bases showed an excellent fitting accuracy. The SLA-printed CDs demonstrated a clinically acceptable fitting accuracy.

Purpose This study evaluated the effects of different materials (composite resin system including a photo-cure adhesive (DC) vs. resin cement system including a self-etching primer (PV)) and techniques (direct vs. indirect) for resin core build-up on the bonding performance to root canal dentin.

Methods The human teeth were decoronated and root canal preparation was performed. All specimens were randomly divided into four groups according to the combinations of the methods (Direct or Indirect) and the materials (DC: Clearfil DC Core, Kuraray Noritake Dental or PV: Panavia V5, Kuraray Noritake Dental). Micro-tensile bond strength (μTBS) and push-out tests were performed. Scanning electron microscope observations of the interface were also performed, and microcomputed tomography and optical coherence tomography were applied to evaluate the sealing ability.

Results The Indirect group had significantly higher μTBSs than the Direct group in the DC group (P = 0.0076). The PV group had significantly higher bond strengths than the DC group in both the Direct and Indirect groups (P < 0.001). The Direct/PV group demonstrated significantly higher push-out bond strength than the Direct/DC group (P < 0.001). In the Direct/PV group, the formation of resin tags was observed even on the apical side of the canal. Microleakage was more clearly observed in the DC group than in the PV group.

Conclusions PV has a higher bonding ability to root canal dentin than DC. When using DC, the indirect technique exhibited a higher bonding ability than the direct technique.

Patient Palatal lift prostheses (PLPs) are used for dysarthria caused by velopharyngeal incompetence (VPI) and improving hypernasal speech. In this case, we used a PLP with a flexible lift (f-PLP) in a patient with dysphagia associated with VPI due to right-sided cranial nerve injuries after a skull base surgery. We examined its efficacy in swallowing biomechanics and swallowing function using high-resolution manometry (HRM) and videofluoroscopic examination of swallowing (VF). The patient felt that it was easier to swallow with f-PLP. Furthermore, VF indicated that the pharyngeal residue with f-PLP was less than without it. HRM showed that velopharyngeal pressure and intrabolus pressure (IBP) with f-PLP were higher than those without it. Additionally, the upper esophageal sphincter (UES) relaxation time and UES nadir pressure on the patient's healthy left side compared to the right side improved with f-PLP.

Discussion We discovered two clinical outcomes. First, the f-PLP ensured velopharyngeal closure and an increase in the hypopharyngeal IBP, which potentially improved the UES opening on the healthy side. Second, the f-PLP improved pharyngeal clearance, and the patient felt that it was easier to swallow with the f-PLP. This implies that an f-PLP potentially exhibits a positive effect on swallowing.

Conclusions In this case, the f-PLP contributed to improving the pharyngeal passage of a bolus. We suggest that f-PLPs can be used for patients with dysarthria and those with dysphagia with VPI.