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Volume 20 (1997)
- Issue 6 Pages 465-
- Issue 5 Pages 417-
- Issue 4 Pages 241-
- Issue 3 Pages 145-
- Issue 2 Pages 87-
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Volume 20, Issue 3
Displaying 1-8 of 8 articles from this issue
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[in Japanese]1997 Volume 20 Issue 3 Pages 145-151
Published: June 30, 1997
Released on J-STAGE: February 13, 2009
JOURNAL FREE ACCESSDownload PDF (741K) -
Mutsuto Tateishi, Atsuo Taniguchi, Masato Moriguchi, Masako Hara, Sada ...1997 Volume 20 Issue 3 Pages 152-158
Published: June 30, 1997
Released on J-STAGE: February 13, 2009
JOURNAL FREE ACCESSWe studied the efficacy of cyclophosphamide pulse therapy (CYP) for refractory rheumatic diseases except for lupus nephritis. Thirty-five patients were included in all, that is 9 patients with systemic lupus erythematosus (SLE), 10 with rheumatoid arthritis (RA), 7 with polymyositis/dermatomyositis (PM/DM), 2 with progressive systemic sclerosis (PSS), 2 with anti-phospholipid antibody syndrome (APS), 1 with mixed connective tissue disease (MCTD), 1 with juvenile rheumatoid arthritis (JRA), 1 with Behcet's disease (BD), 1 with Wegener's granulomatosis (WG) and 1 with allergic granulomatous angiitis (AGA). Moderate to marked improvement was noted in 4 patients with SLE (2 with CNS-lupus and 2 with vasculitis), 7 with RA (2 with interstitial pneumonia; IP, 2 with vasculitis and 2 with refractory arthritis), 4 with PM/DM (2 with IP and 2 with refractory myositis), 1 PSS with IP, 2 APS with thrombocytopenia, 1 JRA with vasculitis and BD with CNS disturbance. On the other hand, adverse reactions were observed in 9 out of 35 patients (25.8%). CYP should apply in the treatment for such refractory rheumatic diseases as CNS disturbance, vasculitis, IP and autoimmune thrombocytopenia.View full abstractDownload PDF (776K) -
Noriko Ikeda, Akira Ishiguro, Kuniko Uno, Yuji Inaba, Takashi Ishikita ...1997 Volume 20 Issue 3 Pages 159-165
Published: June 30, 1997
Released on J-STAGE: February 13, 2009
JOURNAL FREE ACCESSIL-5 play important roles in inflammatory responses in bronchial asthma, but little is known about serum levels and in vitro production of IL-5 in childhood bronchial asthma. We further examined serum IL-5 levels in children with bronchial asthma and the controls. IL-5 in serum was detected in all of asthmatic and disease-free individuals. Its values during asthma exacerbation were significantly higher than during remission of asthma. Serum IL-5 values did not significantly differ among groups divided by asthma severity. We studied IL-5 production by peripheral blood mononuclear cells cultured with or without Dermatophagoides farinae (Df) in children with mite allergy. IL-5 concentrations in culture supernatant from after stimulation with Df were significantly higher than those from asthmatic patients without stimulation and from the control subjects. In contrast, IL-5 levels in culture media from the controls were not significantly different between with and without stimulation with Df. Our results suggest that IL-5 may play roles in the pathogenesis of bronchial asthma.View full abstractDownload PDF (394K) -
the effects of Corticosteroid and Other ImmunosuppressantsNaoto Shimetani, Hideki Ohtani1997 Volume 20 Issue 3 Pages 166-177
Published: June 30, 1997
Released on J-STAGE: February 13, 2009
JOURNAL FREE ACCESSBoth C-reactive protein (CRP) and serum amyloid A protein (SAA) are determined as an indicator of inflammation and tissue damage. We found that CRP decreased extremely after administration of corticosteroid but SAA did not. However, the mechanism of the CRP decrease by corticosteroid therapy is unclear. In this study we have examined the effects of some immunosuppressive drugs and cytokines on the production of CRP and SAA by human hepatoma cells (HepG 2).
A corticosteroid prednisolone did not enhance the production of CRP by HepG 2 cells but enhanced that of SAA, which indicate that prednisolon had no direct effect on the CRP production. Some immunosuppressants other than corticosteroids suppressed the SAA production but had no effect on the CRP production. IL-1β induced both CRP and SAA production but only in the co-presence of IL-6. A cytokine IL-6 induced the CRP production in the presence of IL-1β but did not affect the constitutive production of SAA.
Then we have examined the cytokine production by monocytes stimulated by lipopolysaccharide. Prednisolone inhibited the production of IL-1α IL-1β IL-6 and TNFα.View full abstractDownload PDF (1245K) -
Setsuko Nakata, Kazunaga Uematsu, Tetsuo Mori, Norie Mitsushita, Tatsu ...1997 Volume 20 Issue 3 Pages 178-183
Published: June 30, 1997
Released on J-STAGE: February 13, 2009
JOURNAL FREE ACCESSA 13-year-old girl with mixed connective tissue disease (MCTD) was described. She visited our hospital with recurrent parotid gland swelling, arthritis, and myositis. Sclerodactyly and Raynaud's phenomenon were also defined, and the laboratory findings of high titers of antinuclear antibody (speckled type), positive anti-RNP antibody, positive rheumatoid factor, and hypergammaglobulinemia suggested the diagnosis of MCTD associated with Sjögren syndrome. The muscle weakness and the increased levels of CK prompted us to examine the muscle biopsy and to perform the electromyography, both of which suggested severe muscle inflammation. The siarography and lip biopsy indicated definitively the association of Sjögren syndrome. Corticosteroid therapy including methylprednisolon pulses was started, but the effects were limited. The addition of low-dose methotrexate effectively lowered the levels of CK, and gradually improved the muscle strength. Thus, low-dose methotrexate therapy is recommended to the patients with MCTD who have severe myositis refractory to corticosteroid.View full abstractDownload PDF (797K) -
Yukitomo Urata, Midori Hasegawa, Hiroshi Hasegawa, Masahiko Shikano, S ...1997 Volume 20 Issue 3 Pages 184-190
Published: June 30, 1997
Released on J-STAGE: February 13, 2009
JOURNAL FREE ACCESSSplenectomized patients are likely to suffer from severe infections, such as sepsis and meningitis. This syndrome is called overwhelming postsplenectomy infection (OPSI) in Europe and America. The course is rapid, the clinical symptoms are serious, and the prognosis is very poor. We treated one adult patient with OPSI syndrome that developed 10 years after splenectomy.
Case: A 26-year-old man had undergone a splenectomy following a traffic accident 10 years previously. On January 7, 1996, he had diarrhea and nausea. On January 10, he became drowsy and presented at our hospital with multiple organ failure.
He underwent hemodialysis and plasmapheresis because of acute renal failure and also received immue globulin, antibiotics and prednisolone. However, these medications were not effective. He died 7 hours later. We identified diplococcus on a blood smear, IgG 3 deficiency and a low titer of specific pneumococcal IgG 2 antibody. The autopsy findings in cluded bilateral acute hemorrhagic necrosis of the adrenal glands (Waterhouse-Friderichsen syndrome).View full abstractDownload PDF (2037K) -
Junko Nishio, Ryuji Koike, Hideki Iizuka, Toshihiro Nanki, Noboru Mizu ...1997 Volume 20 Issue 3 Pages 191-198
Published: June 30, 1997
Released on J-STAGE: February 13, 2009
JOURNAL FREE ACCESSWe report here a case of adult-onset Still's disease (AOSD), who finally responded to a combination of cyclophosphamide (CPA) and gold sodium thiomalate (GST) after two years of active disease. A 23-year-old man having continuous high fever with skin rash, polyarthralgia and increased serum ferritin, was diagnosed as AOSD, and oral corticosteroid was initially effective. His symptoms reccured one year later without clinical improvement to increased dosage of steroid. He was admitted to our hospital with pericarditis and pleural effusion but did not respond to either intravenous (IV) pulse steroid therapy, methotrexate (MTX) or high dose IV γ-globulin. He was partly responsive to monthly IV injection of CPA, but clinical symptoms did not completely subside and hyperferritinemia persisted. GST, initiated in combination with CPA, however, was successful to induce complete remission.
MTX has recently been reported to be efficacious to steroid-resistant AOSD, but CPA and gold compounds might be useful to refractory case of AOSD.View full abstractDownload PDF (1548K) -
Sachiko Takaoka, Masanori Higuchi, Keita Odashiro, Shigeru Yoshizawa, ...1997 Volume 20 Issue 3 Pages 199-205
Published: June 30, 1997
Released on J-STAGE: February 13, 2009
JOURNAL FREE ACCESSA 43-year-old woman was admitted to our hospital for evaluation of shortness of breath and palpitation on exertion. She had a 20-year history of dry mouth and a 10-year history of recurrent pneumonia. She had been diagnosed as having primary Sjögren's syndrome with interstitial pneumonia at 42 years of age. On admission, cardiac ultrasonography revealed reduced left ventricular systolic function. Complications that would elicit cardiac manifestations such as viral myocarditis, amyloidosis, sarcoidosis, and ischemic heart disease, were excluded. Oral corticosteroid therapy was effective for alleviating symptoms. In this patient, it appears that primary Sjögren's syndrome is involved in the reduced left ventricular systolic function.View full abstractDownload PDF (1090K)
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