Japanese Journal of Clinical Immunology
Online ISSN : 1349-7413
Print ISSN : 0911-4300
ISSN-L : 0911-4300
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Volume 36, Issue 5
The 41st Annual Meeting of the Japan Society for Clinical Immunology
Displaying 1-50 of 196 articles from this issue
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Special Lecture
  • Special Lecture 1  Recent advances in the genetics of rheumatoid arthritis
    Soumya RAYCHAUDHURI
    2013Volume 36Issue 5 Pages 294-295
    Published: 2013
    Released on J-STAGE: October 31, 2013
    DOIhttps://doi.org/10.2177/jsci.36.294
    JOURNAL FREE ACCESS
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     Family studies have long demonstrated that rheumatoid arthritis susceptibility is linked to an underlying genetic component, both inside and outside of the major histocompatibility complex (MHC). The last decade has seen incredible advances in the discovery of risk loci for rheumatoid arthritis; now there are about 100 disease loci that have been identified. However, understanding the link between genetic loci and disease mechanism, is contingent on investigators identifying causal alleles and elucidating how they function to modify disease susceptibility. We are now just beginning to make this key step. Here we present recent work on (1) efforts to identify rheumatoid arthritis loci outside of the MHC region, (2) efforts within our own group to localize MHC effects to functional amino acid sites within HLA genes, separately for seronegative and seropositive rheumatoid arthritis, and (3) methodological advance to connect non-MHC loci to functional alleles that influence gene regulation in specific immune cell-types.
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  • [title in Japanese]
    [in Japanese]
    2013Volume 36Issue 5 Pages 296-297
    Published: 2013
    Released on J-STAGE: October 31, 2013
    DOIhttps://doi.org/10.2177/jsci.36.296
    JOURNAL FREE ACCESS
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    [in Japanese]
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