Japanese Journal of Clinical Immunology
Online ISSN : 1349-7413
Print ISSN : 0911-4300
ISSN-L : 0911-4300
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Volume 24, Issue 6
Displaying 1-7 of 7 articles from this issue
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  • Characterization of autoantibodies to 60-kD SS-A, 52-kD SS-A and SS-B in Japanese lupus mothers with neonatal lupus syndrome
    Rieko Kawaguchi, Yoshinari Takasaki, Kaoru Hirokawa, Ken Takeuchi, Kaz ...
    2001 Volume 24 Issue 6 Pages 291-302
    Published: December 31, 2001
    Released on J-STAGE: February 13, 2009
    DOIhttps://doi.org/10.2177/jsci.24.291
    JOURNAL FREE ACCESS
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    It has been reported that the majority of infants with the neonatal lupus syndrome (NLS) are born to mothers with systemic lupus erythematosus (SLE). We tested for anti-SS-A and -SS-B antibodies in 9 Japanese mothers with lupus whose newborns had NLS (NLS group) and 33 others whose newborns did not have NLS (non-NLS group). Anti-SS-A antibodies were detected by double immunodiffusion (DID) in 100% of NLS group and in 63.6% of non-NLS group. Anti-SS-B antibodies were detected by DID in 55.6% of NLS group and in 12.1% of non-NLS group. By enzyme-linked immunosorbent assay (ELISA), anti-SS-B antibodies were present in 55.6% of NLS group and in 33.3% of non-NLS group. Immunoblotting (IB) showed a higher prevalence of anti-SS-B antibodies in NLS group than DID or ELISA. NLS group often had antibodies against 60-kD and 52-kD SS-A, and SS-B (77.8%), but never had antibodies reactive only with 60-kD SS-A. IB for detecting 60- and 52-kD SS-A, and SS-B proved to be the best test for assessing the risk of NLS complicating in maternal lupus.
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  • Evaluation of platelet aggregation in patients with Raynaud's phenomenon: Particularly on concerning the effect of serotonergic receptor (5-HT 2 A) antagonist
    Hidekazu Kosaka, Katsuyasu Saigo, Jun Saegusa, Tomoko Nakamura, Masahi ...
    2001 Volume 24 Issue 6 Pages 303-310
    Published: December 31, 2001
    Released on J-STAGE: February 13, 2009
    DOIhttps://doi.org/10.2177/jsci.24.303
    JOURNAL FREE ACCESS
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    Abnormalities in interactions in platelets and endothelial cells triggered by temporary microscopic thrombosis induced by serotonin in peripheral blood are noted for a potential cause for Raynaud's phenomenon. First, we evaluated the spontaneous and serotonin-induced platelet aggregation of patients with Raynaud's phenomenon using by laser-light scattering platelet aggregometer. Next, the changes in platelet aggregation of the patients were observed before and after treatment with a serotonergic receptor (5-HT 2 A) antagonist, sarpogrelate hydrochloride (SPG). Ten patients with Raynaud's phenomenon and ten healthy controls were enrolled in this study. Spontaneous aggregation was not detected in controls and patients before and after the SPG treatment. Serotonin-induced aggregation was significantly less in patients before the treatment than in healthy controls. After eight-week treatment with SPG, serotonin-induced aggregation unexpectedly showed a tendency to increase compared with that in patients before treatment. The observed platelet hyperag-gregation against exogenous serotonin after the SPG treatment may be due to the up-regulation of serotonergic receptors on platelet surface in response to the long-term reduction of plasma serotonin.
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  • A case of mixed connective tissue disease with chronic non-suppurative cholangitis
    Kazue Matoba-Ueno, Takashi Fujimoto, Hideto Uyama
    2001 Volume 24 Issue 6 Pages 311-316
    Published: December 31, 2001
    Released on J-STAGE: February 13, 2009
    DOIhttps://doi.org/10.2177/jsci.24.311
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    A 28-year-old woman was admitted to our hospital in August 1998, because of high grade fever, anorexia, and general fatigue. She had been diagnosed as having mixed connective tissue disease (MCTD) because of Raynaud's phenomenon, sausage like fingers, positive anti U 1-RNP antibody, multiple arthralgia, and sclerodactyly. The laboratory examination revealed the marked elevation of serum GOT (3, 712IU/L), GPT (2, 246IU/L), and LDH (5, 907IU/L). The antibodies suggestive of participation of viral hepatitis, such as serum IgM class of anti-hepatitis A, hepatitis B antigen, and anti-hepatitis C were negative. The liver biopsy showed cellularly enlarged portal areas and damaged interlobular bile ducts with altered biliary epithelium. This is the report of a rare case with MCTD associated with chronic non-suppurative cholangitis probably induced by autoimmune mechanism.
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  • [title in Japanese]
    [in Japanese], [in Japanese]
    2001 Volume 24 Issue 6 Pages 319-326
    Published: December 31, 2001
    Released on J-STAGE: February 13, 2009
    DOIhttps://doi.org/10.2177/jsci.24.319
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  • [title in Japanese]
    [in Japanese], [in Japanese]
    2001 Volume 24 Issue 6 Pages 327-335
    Published: December 31, 2001
    Released on J-STAGE: February 13, 2009
    DOIhttps://doi.org/10.2177/jsci.24.327
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    2001 Volume 24 Issue 6 Pages 336-346
    Published: December 31, 2001
    Released on J-STAGE: February 13, 2009
    DOIhttps://doi.org/10.2177/jsci.24.336
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    2001 Volume 24 Issue 6 Pages 347-354
    Published: December 31, 2001
    Released on J-STAGE: February 13, 2009
    DOIhttps://doi.org/10.2177/jsci.24.347
    JOURNAL FREE ACCESS
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