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Yutaka Mizushima
2000 Volume 23 Issue 6 Pages
477-480
Published: December 31, 2000
Released on J-STAGE: February 13, 2009
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Toshihiko Nagasawa
2000 Volume 23 Issue 6 Pages
481-484
Published: December 31, 2000
Released on J-STAGE: February 13, 2009
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RN Maini, PC Taylor, E Paleolog, P Charles, S Ballara, FM Brennan, M F ...
2000 Volume 23 Issue 6 Pages
487-489
Published: December 31, 2000
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John A Snowden
2000 Volume 23 Issue 6 Pages
490-493
Published: December 31, 2000
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[in Japanese]
2000 Volume 23 Issue 6 Pages
497-498
Published: December 31, 2000
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Tsuyoshi Sakane, Noboru Suzuki
2000 Volume 23 Issue 6 Pages
499-504
Published: December 31, 2000
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Shizuo Akira
2000 Volume 23 Issue 6 Pages
505-510
Published: December 31, 2000
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Kohei Miyazono
2000 Volume 23 Issue 6 Pages
511-513
Published: December 31, 2000
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Hiroshi Hashimoto
2000 Volume 23 Issue 6 Pages
514-518
Published: December 31, 2000
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Takashi Shimada
2000 Volume 23 Issue 6 Pages
519-522
Published: December 31, 2000
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Shumpei Yokota
2000 Volume 23 Issue 6 Pages
523-526
Published: December 31, 2000
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Noboru Mizushima
2000 Volume 23 Issue 6 Pages
527-530
Published: December 31, 2000
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Kazuyoshi Saito, Koichi Fujii, Yuichiro Awazu, Shingo Nakayamada, Kazu ...
2000 Volume 23 Issue 6 Pages
533-537
Published: December 31, 2000
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Yosikata Misaki, Keigo Setoguchi, Yasuto Araki, Keishi Fujio, Kimito K ...
2000 Volume 23 Issue 6 Pages
538-541
Published: December 31, 2000
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For the treatment of rheumatoid arthritis, efficient drug delivery methods to the inflamed joints need to be developed. Since T cells expressing an appropriate autoantigen-specific receptor can migrate to inflamed lesions, it has been reasoned that they can be employed to deliver therapeutic agents. In order to examine the ability and efficiency of such T cells as a vehicle, we employed an experimentally induced model of arthritis. Splenic T cells from DO 11.10 T cell receptor transgenic mice specific for OVA were transduced with murine IL-10. Adoptive transfer of the IL-10-transduced DO 11.10 splenocytes ameliorated OVA-induced arthritis, in spite of the presence of around 95% non-transduced cells. Using GFP as a marker for selection, the number of transferred cells needed to ameliorate the disease was able to be reduced to 10
4. Preferential accumulation of the transferred T cells was observed in the inflamed joint, and the improvement in the disease was not accompanied by impairment of the systemic immune response to the antigen, suggesting that the transferred T cells exert their antiinflammatory task locally, mainly in the joints where the antigen exists. In addition, IL-10-transduced DO 11.10 T cells ameriolated mBSA-induced arthritis when the arthritic joint was co-injected with OVA in addition to mBSA. These results suggest that T cells specific for a joint specific antigen would be useful as a therapeutic vehicle in rheumatoid arthritis for which the arthritic autoantigen is still unknown.
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Satoshi Iyama, [in Japanese], [in Japanese], [in Japanese], [in Japane ...
2000 Volume 23 Issue 6 Pages
542
Published: December 31, 2000
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Tetsuya Kobayashi, Kazuyoshi Okamoto, Kusuki Nishioka
2000 Volume 23 Issue 6 Pages
543-546
Published: December 31, 2000
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Hiroshi Takayanagi, Takuo Juji, Tsuyoshi Miyazaki, Hideharu Iizuka, Sa ...
2000 Volume 23 Issue 6 Pages
547-549
Published: December 31, 2000
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Hitoshi Kohsaka, Kimio Nasu, Yoshinori Nonomura, Nobuyuki Miyasaka
2000 Volume 23 Issue 6 Pages
550-552
Published: December 31, 2000
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Masataka Kuwana, Yutaka Kawakami, Yasuo Ikeda
2000 Volume 23 Issue 6 Pages
555-557
Published: December 31, 2000
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Minoru Nakamura, Shinji Shimoda, Hiromi Ishibashi
2000 Volume 23 Issue 6 Pages
558-563
Published: December 31, 2000
Released on J-STAGE: May 26, 2009
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Akiko Maeda, Hiroshi Ohguro, Noriyuki Sato
2000 Volume 23 Issue 6 Pages
564-567
Published: December 31, 2000
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Saburo Saito
2000 Volume 23 Issue 6 Pages
568-570
Published: December 31, 2000
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Sho Matsushita, Hideki Ohyama, Yoshihiko Tanaka
2000 Volume 23 Issue 6 Pages
571-576
Published: December 31, 2000
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Jun Kunisawa, Gaku Sakaue, Hiroshi Kiyono
2000 Volume 23 Issue 6 Pages
579-581
Published: December 31, 2000
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Yoshio Koyanagi
2000 Volume 23 Issue 6 Pages
582-585
Published: December 31, 2000
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Potent stimuli for CD 4
+ T cell differentiation are cytokines. Among them, IL-12 or IL-4 induce naive CD 4
+ T cells to Th 1 or Th 2 cells, respectively. In this study we found that macrophage-tropic (M-tropic) HIV-1 strains more efficiently replicated in interleukin 12 (IL-12) induced T helper 1 (Th 1)-type culture derived from normal CD 4
+ T cells than T-cell-line-tropic (T-tropic) strains did. In contrast, T-tropic strains preferentially infected IL-4 induced Th 2-type culture derived from same donor CD 4
+ T cells. Additional studies using chimeric viruses demonstrated that the V 3 region of gp 120 was the principle determinant for this efficient replication. It was also isolated T-tropic viruses from an acutely infected patient who had been evidenced as severe CD 4 depletion during short time course. These results indicate that HIV-1 isolates exhibit differences in the ability to infect CD 4
+ T cell subset such as Th 1 or Th 2 cells, and that this difference may partly correlate with the viral pathogensesis. The findings suggest that immunological condition is one of the factors responsible for inducing selection of HIV-1 strains.
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Norihiro Nishimoto, Takako Okura, Jian Song, Reiko Inagi, Yasuko Mori, ...
2000 Volume 23 Issue 6 Pages
586-590
Published: December 31, 2000
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[in Japanese]
2000 Volume 23 Issue 6 Pages
591
Published: December 31, 2000
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Kazuhisa Sugimura, Mutsukazu Mitarai, Yasuhiko Shinmura, Shuhei Hashig ...
2000 Volume 23 Issue 6 Pages
592-596
Published: December 31, 2000
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Kazuhiko Takehara
2000 Volume 23 Issue 6 Pages
599-602
Published: December 31, 2000
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Yasuhiko Ito
2000 Volume 23 Issue 6 Pages
603-606
Published: December 31, 2000
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Toshifumi Hibi, Taknaori Kanai, Mamoru Watanabe, Satoshi Okazawa, Tosh ...
2000 Volume 23 Issue 6 Pages
607-610
Published: December 31, 2000
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Kozo Kayano, Eiki Sakaguchi, Isao Sakaida, Kiwamu Okita
2000 Volume 23 Issue 6 Pages
611-612
Published: December 31, 2000
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Seijiro Mori, Yasushi Saito
2000 Volume 23 Issue 6 Pages
613-617
Published: December 31, 2000
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Masanori Niimi
2000 Volume 23 Issue 6 Pages
621-626
Published: December 31, 2000
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Hiroo Uchida, Hirokazu Tanaka, Kazunori Tahara, Eiji Kobayashi
2000 Volume 23 Issue 6 Pages
627-629
Published: December 31, 2000
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Toshihiko Hirano, Kitaro Oka, Naoto Matsuno, Takeshi Nagao
2000 Volume 23 Issue 6 Pages
630-633
Published: December 31, 2000
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
2000 Volume 23 Issue 6 Pages
634
Published: December 31, 2000
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
2000 Volume 23 Issue 6 Pages
635
Published: December 31, 2000
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Hiroto Egawa, Fumitaka Oike, Koichi Tanaka
2000 Volume 23 Issue 6 Pages
636-639
Published: December 31, 2000
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Okada Jun, Koredo Keiko, Kondo Hirobumi
2000 Volume 23 Issue 6 Pages
643-646
Published: December 31, 2000
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Tsuneyo Mimori, Hidekata Yasuoka, Misako Suzuki, Takaki Nojima, Shinji ...
2000 Volume 23 Issue 6 Pages
647-651
Published: December 31, 2000
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Masaaki Nakano
2000 Volume 23 Issue 6 Pages
652-655
Published: December 31, 2000
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Hirahito Endo
2000 Volume 23 Issue 6 Pages
656-660
Published: December 31, 2000
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Yasushi Kamiya, Kimimasa Nakabayashi, Yoshihiro Arimura, Toshihiko Nag ...
2000 Volume 23 Issue 6 Pages
661-664
Published: December 31, 2000
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
2000 Volume 23 Issue 6 Pages
665
Published: December 31, 2000
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Yasushi Nawata, Katsuhiko Takabayashi, Kazuhiro Kurasawa, Itsuo Iwamot ...
2000 Volume 23 Issue 6 Pages
666-669
Published: December 31, 2000
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Shunichi Kumakura, Masahiko Kondo, Hiroto Tsumura, Yohko Murakawa, Hir ...
2000 Volume 23 Issue 6 Pages
670-673
Published: December 31, 2000
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Kozo Kitazawa, Emiko Furuta, Tetsuzo Sugisaki
2000 Volume 23 Issue 6 Pages
674-676
Published: December 31, 2000
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Peter E. Lipsky
2000 Volume 23 Issue 6 Pages
679-682
Published: December 31, 2000
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Carlo Patrono
2000 Volume 23 Issue 6 Pages
683-685
Published: December 31, 2000
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