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Volume 21 (1998)
- Issue 5 Pages 181-
- Issue 4 Pages 145-
- Issue 3 Pages 95-
- Issue 2 Pages 65-
- Issue 1 Pages 1-
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Volume 21, Issue 4
Displaying 1-6 of 6 articles from this issue
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Yukio Sakiyama1998 Volume 21 Issue 4 Pages 145-149
Published: August 31, 1998
Released on J-STAGE: February 13, 2009
JOURNAL FREE ACCESSDownload PDF (379K) -
Rie Takada, Maiko Matsumoto, Memi Yosida, Takaki Nojima, Michito Hirak ...1998 Volume 21 Issue 4 Pages 150-158
Published: August 31, 1998
Released on J-STAGE: February 13, 2009
JOURNAL FREE ACCESSTo detect immunoglobulin isotype-specific autoantibodies to native human calpastatin in patients with rheumatic diseases, we performed immunoblot analysis using the heated HeLa cell extracts to enrich heat-resistant calpastatin. The calpastatin molecule that was apparently migrated to 110 kD by SDS-PAGE was confirmed to react with monoclonal anti-human calpastatin antibody in immunoblotting. IgG antibodies to calpastatin were detected in 22 of 48 sera(46%) from patients with RA, whereas only 20% (5/25), 11% (2/19) and 13% (2/15) of sera from SLE, SSc and PM/DM had IgG anti-calpastatin antibodies, respectively. IgM antibodies were also found in 40% (19/48) of RA and 12% (3/25) of SLE patients but not detected in sera from patients with other rheumatic diseases. IgA antibodies were found in only one RA and one SLE serum. In RA, 7 of 48 sera (15%) had IgM antibodies alone, but all SLE sera with IgM antibodies had IgG antibodies. Thus, anti-calpastatin autoantibodies were detected by using the native human calpastatin. Although these autoantibodies were found in patients with various rheumatic diseases, they were present in RA patients at the highest frequency. In particular, the presence of IgM antibodies appeared to be more specific in RA patients.View full abstractDownload PDF (1610K) -
Masanori Aoki, Akira Suwa, Ayako Nakajima, Shinji Satoh, Makoto Ishi, ...1998 Volume 21 Issue 4 Pages 159-165
Published: August 31, 1998
Released on J-STAGE: February 13, 2009
JOURNAL FREE ACCESSHere we, report a case of systemic sclerosis (SSc) complicated with pneumoperitoneum and pneumatosis cystoides intestinalis (PCI).
A 58-year-old woman who had been treated with oxygen therapy for chronic respiratory failure caused by interstitial pneumonia was admitted to Tokyo Metropolitan Ohtsuka Hospital because of abdominal fullness. On admision, laboratory data showed accelerated erythrocyte sedimentation rate, mild anemia, hypoalbuminemia, and elevated level of lactose dehydrogenase (LDH). Anti-nuclear antibodies, anti-RNP antibodies, anti-Topoisomerase I antibodies, anti-Ku antibodies, and rheumatoid factor were positive. Chest and abdominal roentgenograms showed free air under the diaphragm, dilatation of small intenstine and colon, and multiple intestinal cysts. The diagnosis of pneumoperitoneum and PCI was made with laboratory findings and radiographic findings. Her symptoms did not respond to medications altering colonic motility and oxygen therapy. Finally, abdominal symptoms and radiographic findings caused by pneumoperitoneum and PCI disappeared three weeks after treatment with 1, 500 mg/day of kanamycin sulfate.
PCI is rarely associated with SSc. Possible pathogenic relationship between these diseases was discussed.View full abstractDownload PDF (1389K) -
Shinji Satoh, Michito Hirakata, Hideto Kameda, Nobuaki Hama, Tadashi Y ...1998 Volume 21 Issue 4 Pages 166-171
Published: August 31, 1998
Released on J-STAGE: February 13, 2009
JOURNAL FREE ACCESSA 47 year-old Japanese female who showed transverse myelopathy (TM) due to spinal epidual hematoma diagnoted by MRI in the course of systemic lupus erythematosus (SLE) was reported.
She was admitted to Keio University Hospital due to paraplegia, anesthesia of lower extremity, urinary disturbance. Neurological examination revealed transverse disturbance of Th 10. Lumbar spinal cord MRI showed irregular mass that located at epidural region of 9th-11th thoratic vertebrae. When the laminectomy of 9th-11th thoratic vertebrae was performed, hematoma (4.5cm×1.5cm in size) was confirmed and removed completely. Post operative condition was stable and symptoms had been improving gradually.
It has been reported that TM associated with SLE was closely related to myelitis. In this case, epidural hematoma was a major cause of TM and MRI was very useful for her diagnosis and treatment.
This is the rare case of SLE associated with spinal epidural hematoma and was thought as a important case to consider the cause of neurological complication of SLE.View full abstractDownload PDF (1175K) -
Wakako Fukui, Hajime Sano, Tomoko Tanabe, Tomoko Ueda, Shunsei Hirohat ...1998 Volume 21 Issue 4 Pages 172-179
Published: August 31, 1998
Released on J-STAGE: February 13, 2009
JOURNAL FREE ACCESSWe report here a case of neuropsychiatric lupus erythematosus with organic brain syndrome and transverse myelitis which was successfully managed by plasmapheresis.
A 27-year-old female with facial rash, arthralgia and fever was diagnosed as having SLE and treated with oral prednisolone (PSL) in June 1996. After 6 weeks she demonstrated muscle pain and a spiking temperature. The dose of PSL was increased but clinical symptoms did not improve. In August, pulse methyl-PSL was performed and she subsequentlydeveloped delirium, impairment of orientation, memory and perception, which were followed by paraplegia of the lower extremities and loss of sphincter control. Intravenous bolus cyclophosphamide was not effective, but liver dysfunction, bone marrow suppression and respiratory failure due to an infection of pneumocystis carinii were observed. We then performed plasmapheresis or immunoabsorption several times. After this treatment steady improvement was observed. High values of antiribosomal P protein antibodies in the serum and interleukin-6 in the cerebrospinal fluid decreased. Small foci of increased signal intensity detected on cranial magnetic resonance imaging and hypoperfused areas on singlephoton emission CT diminished.
The patient was maintained on low-dose PSL and no recurrence has been observed 15 months from the onset.View full abstractDownload PDF (1788K) -
1998 Volume 21 Issue 4 Pages e2
Published: 1998
Released on J-STAGE: February 13, 2009
JOURNAL FREE ACCESSDownload PDF (16K)
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