Japanese Journal of Clinical Immunology

Cytokine and cytokine receptor deficiencies causing defects in T cell/Th 1 cell differentiation and function

Toshiro Hara, Yuka Sasaki, Akihiko Nomura, Hideki Takada

2000 Volume 23 Issue 3 Pages 173-180
Published: June 30, 2000
Released on J-STAGE: February 13, 2009

DOIhttps://doi.org/10.2177/jsci.23.173

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[title in Japanese]

[in Japanese]

2000 Volume 23 Issue 3 Pages 181-191
Published: June 30, 2000
Released on J-STAGE: February 13, 2009

DOIhttps://doi.org/10.2177/jsci.23.181

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A case of systemic lupus erythematosus associated with superior vena cava syndrome

Isamu Kingetsu, Daitaro Kurosaka, Nobuya Hashimoto, Naoko Tajima

2000 Volume 23 Issue 3 Pages 192-199
Published: June 30, 2000
Released on J-STAGE: February 13, 2009

DOIhttps://doi.org/10.2177/jsci.23.192

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We report on a case of systemic lupus erythematosus associated with superior vena cava syndrome.
A 46-year-old woman developed polyarthralgia in December 1994. She was treated with nonsteroidal anti-inflammatory drugs. In February 1995, she was admitted to our hospital with systemic convulsion and disturbance of consciousness (III-300/Japan coma scale). Severe facial edema was also present. Laboratory studies revealed the presence of antinuclear antibody, anti-DNA antibody, anti-Sm antibody, and proteinuria. An X-ray film of the chest showed pericardial effusion and bilateral pleural effusions. Computed tomography of the chest showed a severe swelling of mediastinal lymph nodes. A diagnosis of systemic lupus erythematosus was made according to the American Rheumatism Association criteria. Initial treatment with intravenous dexamethasone improved the level of consciousness and decreased the facial edema, mediastinal lymphadenopathy, and the effusions on computed tomography of the chest.
We believe that the most likely explanation for the facial edema is superior vena cava syndrome due to severe mediastinal lymphadenopathy.

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A Case of aseptic osteomyelitis with heel ulcer improved by steroid application

Masashi Idogawa, Hiroki Takahashi, Tomohiko Soma, Mami Mihara, Tsuneno ...

2000 Volume 23 Issue 3 Pages 200-208
Published: June 30, 2000
Released on J-STAGE: February 13, 2009

DOIhttps://doi.org/10.2177/jsci.23.200

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A 43-year-old male patient was admitted to our hospital because of left heel pain and fever. He had had swelling of the left ankle joint and pain 4 years prior to this, and 4 years later, he was admitted to another hospital when left heel ulcer and fever developed. The ulcer was diagnosed and treated as a diabetic ulcer because of hyperglycemia. In spite of good control of blood sugar, the ulcer became enlarged and the pain deteriorated, so he was transferred to orthopedics. Antibiotics produced no response, and culture from a specimen of the ulcer was negative. However, severe inflammatory response was seen in blood examination. MRI and scintigram of his left foot showed disseminated low intensity areas and accumulation in the tarsal bone area, so osteomyelitis was suspected. A biopsy of the ulcer showed infiltration of inflammatory cells into the dermis. We considered amputation of the left lower leg at first. However the biopsy result suggested an autoimmune mechanism, so prednisolone was administered. As a result, the ulcer and pain both diminished. This case was similar to pyoderma gangenosum, however this diagnosis cannot explain osteomyelitis or all its symptoms. We expect that there must be other case report with the same symptoms.

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