Japanese Journal of Clinical Immunology
Online ISSN : 1349-7413
Print ISSN : 0911-4300
ISSN-L : 0911-4300
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Volume 24, Issue 2
Displaying 1-3 of 3 articles from this issue
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  • Immunological mechanisms of acquired aplastic anemia
    Tadatsugu Sato
    2001 Volume 24 Issue 2 Pages 65-74
    Published: April 30, 2001
    Released on J-STAGE: February 13, 2009
    DOIhttps://doi.org/10.2177/jsci.24.65
    JOURNAL FREE ACCESS
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  • Autoimmune hepatitis associated with mixed connective tissue disease: Report of a case and a review of the literature
    Shigehisa Aoki, Yoshifumi Tada, Akihide Ohta, Syuichi Koarada, Osamu U ...
    2001 Volume 24 Issue 2 Pages 75-80
    Published: April 30, 2001
    Released on J-STAGE: February 13, 2009
    DOIhttps://doi.org/10.2177/jsci.24.75
    JOURNAL FREE ACCESS
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    A case is reported of a 29 year old female who had autoimmune hepatitis associated with mixed connective tissue disease (MCTD). The patient developed MCTD at the age of 19, and was treated with prednisolone. Liver dysfunction developed 7 years later, which exacerbated shortly after the patient suffered intrauterine fetal death during the second trimester of pregnancy. Laboratory data showed negative anti-hepatitis C antibody and hepatitis B antigen, but positive anti-smooth muscle antibody. A liver biopsy showed chronic active hepatitis. Referring to the criteria we diagnosed her as having autoimmune hepatitis. Although hepatomegaly is sometimes observed in MCTD patients, only 5 cases of autoimmune hepatitis associated with MCTD have been reported in the past. In our case, it is of note that autoimmune hepatitis developed while symptoms of MCTD were in remission, and that autoimmune hepatitis exacerbated with the emergence of anti-smooth muscle antibody following the termination of pregnancy.
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  • Association of Idiopathic Thrombocytopenic Purpura and Type 1 Diabetes Mellitus in a Patient with Sarcoidosis
    Tohru Takahashi, Yoshie Kazama, Haruo Shimizu, Mitsuru Yoshimoto, Masa ...
    2001 Volume 24 Issue 2 Pages 81-86
    Published: April 30, 2001
    Released on J-STAGE: February 13, 2009
    DOIhttps://doi.org/10.2177/jsci.24.81
    JOURNAL FREE ACCESS
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    Occurrence of autoimmune diseases with sarcoidosis is well known. However, a case in which more than one of these diseases coexist with sarcoidosis is rare. We present a young man with suspected sarcoidosis, complicated by idiopathic thrombocytopenic purpura (ITP) and type 1 A diabetes mellitus (DM). A 21-year-old man was admitted to our hospital because of thrombocytopenia, hyperglycemia, and bilateral hilar lymphadenopathy (BHL). Although a histological proof could not be obtained, the patient was considered to have sarcoidosis because 67-gallium scintigraphy disclosed “Lambda” and “Panda” signs which are highly specific for sarcoidosis. Type 1 A DM was also diagnosed as the patient had antiglutamic acid decarboxylase antibodies. The patient disclosed no hepatosplenomegaly or no lymphadenopathy and diagnosis of ITP was confirmed by bone marrow examination. High dose steroid was started as the thrombocytopenia progressed. The platelet number increased satisfactorily and shrinkage of BHL was also observed with the therapy.
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