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Volume 7 (1976)
- Issue 4 Pages 363-
- Issue 3 Pages 269-
- Issue 2 Pages 133-
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Volume 7, Issue 2
Displaying 1-12 of 12 articles from this issue
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[in Japanese]1976 Volume 7 Issue 2 Pages 133-134
Published: June 30, 1976
Released on J-STAGE: June 28, 2010
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Ichiyo OSHIMA, Toyohiko FUNATO, Seizo SAWADA, Shiro SAITO, Suzuyo YAMA ...1976 Volume 7 Issue 2 Pages 135-143
Published: June 30, 1976
Released on J-STAGE: June 28, 2010
JOURNAL FREE ACCESSThe effects of TRH-tartrate (TRH-T), a synthetic TRH analogue, on anterior pituitary hormone release were investigated in 10 normal male adults. In addition, the physical and laboratory findings were examined before and after TRH-T administration to check its side effects.
The intravenous administration of 500μg TRH-T stimulated TSH secretionfollowed by the increase of thyroid hormone (T3 and T4) release in all subjects. The peak levels of plasma TSH were observed between 15 and 30 min after the injec tion with the values of 12.5±1.48μU/ml
Plasma prolactin levels reached to the maximum (12.7±1.72 ng/ml) about 15 min earlier than TSH peak levels.
Plasma GH and LH levels in response to TRH-T were increased in some cases and plasma FSH and cortisol did not show any significant changes after the injection.
No significant side effects were observed in view of physical and laboratory findings in all subjects who were examined before and after TRH-T administration.
These results indicate that TRH-T is a useful tool for testing pituitary reserves of TSH and prolactin, since it posesses a stimulating effect on the hormone release without any significant side effects.View full abstractDownload PDF (1830K) -
A Double Blind Controlled StudyHarukuni URABE, Masaru YASUDA, Yuwao HINO, Shoji TOSHITANI, Michiko TO ...1976 Volume 7 Issue 2 Pages 145-159
Published: June 30, 1976
Released on J-STAGE: June 28, 2010
JOURNAL FREE ACCESSA double blind controlled study is done to compare the efficacy of 0.064% betamethasone 17, 21-dipropionate cream (BD) with that of 0.02% flumethasone pivalate cream (FP) on a hundred and six patients, having eczema with similar lesions on both sides of body, in seven institutions. Both sides of each patient are designed as a randomized block, being allocated by the two kinds of creams at random. That is, a kind of cream is on a random side and then the other cream is on the reverse side, for every patient. Thus the creams are applied two or three times a day for about a week (5-9 days) without any occlusion. General improvements and changes of severity on skin findings are statistically tested by the method of analysis of variance. Also the relative efficacy of BD to FP is tested by a method of Scheffé's paired comparison. Conclusionally, the results due to such analyses show significantly the superiority of BD. In view of the side effects, each patient in exacerbation is investigated, but it is not clear whether the side effects exist or not in this study.View full abstractDownload PDF (1802K) -
Blood Concentration and Urinary ExcretionMasasuke KIMURA, Kyuichi MATSUBAYASHI, Hideo HAKUSUI, Mitsuji SANO, Ta ...1976 Volume 7 Issue 2 Pages 161-170
Published: June 30, 1976
Released on J-STAGE: June 28, 2010
JOURNAL FREE ACCESSThe concentrations of Lofepramine (DB-2182) and its metabolites in human blood and urine were studied by using gas chromatographic-massfragmentography. When administered orally, Lofepramine was well absorbed and rapidly metabolised to the active metabolite: Desipramine. In the case of 50 mg single dose, the maximum blood concentrations of Lofepramine and Desipramine were 13.0-43.0 ng/ml at 1-2 hrs and 2.3-2.9 ng/ml at 1.5-3 hrs, respectively. In 24 hrs, 0.01-0.04% of Lofepramine, 0.1-0.35% of Desipramine and 1-6% of 2-Hydroxydesipramine against initial doses were excreted in urine.
In the chronic treatment, the blood concentration of Desipramine was gradually raised until the steady-state level.
After the final dose, the urinary excretion of Desipramine was continued for 3days.View full abstractDownload PDF (1287K) -
with Reference to RehabilitationHiroaki YANO, Takashi SUGIYAMA, Hirotaka WATANABE, Michio KAYABA, Nobu ...1976 Volume 7 Issue 2 Pages 171-187
Published: June 30, 1976
Released on J-STAGE: June 28, 2010
JOURNAL FREE ACCESSTolperisone hydrochloride (Muscalm) is a new muscle relaxant which mainly inhibits the multisynaptic spinal reflexes.
A multiclinic double-blind controlled trial of Tolperisone in hemiplegic patients as performed from the point of view of rehabilitation. Three participating centers and 15 observers were contributed to the trial.
Of the 93 patients started on the trial, 6 patients dropped out for various reasons. The remaining 87 patients, 60 males and 27 females, were included in the analysis. Randomization assigned 43 patients to Tolperisone and 44 to placebo. Tolperisone, in a dosage of 300 mg per day, was administered during a 6-week period.
Tolperisone was significantly effective compared with placebo in evaluating the spasticity (muscle resistance, reflex and stretch reflex), whereas it was not significantly better than placebo in evaluating the function (gait, balance and ADL). No serious side-effect was encountered.
From the whole assessment, however, it was suggested that Tolperisone, a new muscle relaxant, was also an useful supplementary drug for the successful rehabilitation of hemiplegic patients.View full abstractDownload PDF (2555K) -
[in Japanese]1976 Volume 7 Issue 2 Pages 189-195
Published: June 30, 1976
Released on J-STAGE: June 28, 2010
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[in Japanese]1976 Volume 7 Issue 2 Pages 197-203
Published: June 30, 1976
Released on J-STAGE: June 28, 2010
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[in Japanese], [in Japanese]1976 Volume 7 Issue 2 Pages 205-213
Published: June 30, 1976
Released on J-STAGE: June 28, 2010
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[in Japanese]1976 Volume 7 Issue 2 Pages 215-222
Published: June 30, 1976
Released on J-STAGE: June 28, 2010
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[in Japanese]1976 Volume 7 Issue 2 Pages 223-235
Published: June 30, 1976
Released on J-STAGE: June 28, 2010
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[in Japanese], [in Japanese]1976 Volume 7 Issue 2 Pages 237-246
Published: June 30, 1976
Released on J-STAGE: June 28, 2010
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[in Japanese], [in Japanese]1976 Volume 7 Issue 2 Pages 247-251
Published: June 30, 1976
Released on J-STAGE: June 28, 2010
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