In the previous report the Automatic Cytoscreener was described. It has the function of recognizing a nucleus as a single nucleus and measuring and processing the nuclear area. All the steps including the mechanical operation are completely automated. However the Automatic Cytoscreener has a deficiency that the cytodiagnostic criterion adopted is only one, that is, the area of nucleus. In this report an attempt is made to add the function of measuring optical density to the Automatic Cytoscreener. As a preliminary experiment a prototype apparatus called “Photomicroscanner” has been constructed. The apparatus has functions to obtain several cytophotometric parameters based on the geometry and densitometry of a cell. The area and the total optical density of a cell or a nucleus are calculated automatically and are displayed by the digital display unit, and the scanned images are described on an XY recorder geographically. Eight cytodiagnostic parameters : the area of a cell, the area of a nucleus, the nuclear cytoplasmic ratio, the total optical density of cytoplasm, the total optical density of a nucleus, the average optical density of cytoplasm, the average optical density of a nucleus, and the nuclear cytoplasmic optical density ratio were calculated. None of the above-mentioned parameters was found to be sensitive or specific to detect cancer cells. Then criteria for diagnosing cancer cells were detected by combining these eight parameters. When plural parameters were combined by the logical products, considerable number of combined criteria were found to be sensitive or specific. As a trial a branch logic was tentatively established and memorized in a digital computer. Computer-processed results were satisfactory in the internal sample but less satisfactory in the external sample. Trial and error are to be repeated to establish a cytodiagnostic criterion with high sensitivity and specificity.

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Since accurate tracings of the pulsatile blood pressure and flow have been made possible by various advanced instrumentations, there have been several trials related to extraction of the valuable hemodynamic information from these pulsatile phenomena by analog computation techniques. This paper also deals with a new trial for such data processing systems.
Besides extracted information, which is directly derived from the original input signals such as pressure and flow levels and their amplitudes, maximal and minimal. values and so on, several other kinds of information have been computed by combining these inputs to result in new information such as cardiac power, work, vascular resistance and their peak amplitude and rate of changes. Time intervals of the cardiac cycle and their ratios are also measured and computed with other information.
By this system, about 20 kinds of processed information are simultaneously printed out directly as the correlation diagrams of any desired combinations of processed data by beat-to-beat basis. In order to obtain these on-line and real time presentations of the correlation diagrams, the computed results are sampled and once stored in the analog memories, and they are printed out during the successive cardiac cycle on the XY plotter by the specially designed synchronized command pulses. This system includes about 70 transistorized IC operational amplifiers, four multipliers and dividers, and ten analog memories for computations and storage of sampled data. The synchronized command signal pulses are derived from R spike of ECG and reversal flow of flow input to operate the vacuum type relays through flip flops for the whole system.
Since the original input signals can be given to this system from any biophysical amplifiers or from the magnetic tape, the on-line and real time data processings and plot out can be done during and after the experiments. Some of the processed results identified several new correlations among hemodynamic parameters, which have not yet been published.

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This paper deals with new methods to determine aortic regurgitant flow and cerebral blood flow by means of an analog computer simulation of radiocardiogram and radioencephalogram. A basic mathematical model of transportation process of injected radioisotope in blood circulatory system, which was reported in our preceding paper, is shown and the model is modified to be applied to the cases of aortic regurgitation and cerebral circulatory system. For these two cases, block diagrams and analog simulation circuits of the transportation processes of the injected radioisotope are given, and the aortic regurgitant flow and the cerebral blood flow are determined through analysis of the radiocardiogram and the radioencephalogram by using the analog simulation circuits. Typical clinical results of the two cases are also shown.

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A digital computer program for automated detection and diagnosis of arrhythmia in intensive care is herein reported in detail. R top point, Q beginning point, P top point and T wave in ECG wave are automatically detected by 'Sharpness Selecting' method. Information about ECG is proceeded on line in real time and coded by a definited manner.
For an automated diagnosis of arrhythmia, a 'Matching Table' is programmed, which is composed of the part of matching and answer. A final diagnosis is made after comparing coded data of twenty heart beats with twelve items in the 'Matching Table.'

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本論文は本誌10巻5号に掲載された上記調査結果の報告に追加された付録である。この3編は今回の調査の中にあまりはっきり問題が提起されなかった, 臨床化学検査機器, 核医学計測機器, 医用超音波診断機器について現状紹介を三氏に分担執筆していただいたものである。10巻5号の本調査の報告とあわせて, ご一読いただきたい。

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昭和47年10月企画委員会より評議員およびセンターメンバー各位に, 専門別研究会, 講習会・講演会などにつき以下のごときアンケートをお願いしましたところ, 多数の方からご回答, また貴重なご意見をいただきました。ここにご回答をいただいた方々にお礼申し上げるとともに, その結果を報告いたします。なおこれらの結果は, 今後学会発展のために, いろいろな面で十分に反映させていきたいと思います。

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