Japanese Journal of Smooth Muscle Research
Online ISSN : 1884-8788
Print ISSN : 0374-3527
ISSN-L : 0374-3527
Volume 11, Issue 3
Displaying 1-5 of 5 articles from this issue
  • Takehiko SEMBA, Tsuyoshi MIZONISHI, Kazumoto FUJII
    1975 Volume 11 Issue 3 Pages 87-93
    Published: September 30, 1975
    Released on J-STAGE: July 21, 2010
    JOURNAL FREE ACCESS
    Effects of atropine, physostigmine, duvadilan and tetrodotoxin on the mechanical activity of the longitudinal muscle preparation of dog's stomach in vitro experiments and on the motility of stomach in the same animal in vivo experiments were investigated.
    1. The latency of an atropine-resistant contraction which was produced by stimulation of vagus nerve was increased in period in accordance with the augmentation of concentration of atropine in vitro experiments.
    2. Physostigmine reconstructed the atropine-resistant contraction which was abolished by duvadilan as well as the cholinergic contraction which was abolished by atropine in vivo experiments.
    3. Duvadilan abolished the cholinergic and atropine-resistant contractions in vitro, but in vivo experiments duvadilan abolished only the atropine-resistant contraction.
    4. An atropine-resistant contraction was completely abolished by administration of tetrodotoxin. But the direct electrical stimulation of the muscle caused the contraction of it which was blocked by tetrodotoxin.
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  • Hiroshi SAKAKI
    1975 Volume 11 Issue 3 Pages 95-107
    Published: September 30, 1975
    Released on J-STAGE: March 01, 2011
    JOURNAL FREE ACCESS
    Numerous studies have been reported on the roles of the terminal portion of biliary duct in the mechanism of bile excretion. There is as yet no generally agreed conclusion as to functional independence of terminal biliary duct, however, .
    The present study has been performed in rabbits to investigate the effects of prostaglandins and a few other drugs on the terminal portion of common bile duct, with the results leading to the following conclusions:
    1) The group of muscles comprising the terminal biliary duct of rabbit intercommunicate with the duodenal longitudinal muscle and no histologic evidence has been observed for the presence of any independent sphincter in this portion.
    2) The terminal biliary duct and the adjoining segment of the duodenum display nractically the same attitudes on electromyograms.
    3) The internal pressures of the duodenum and common bile duct were noted to show changes coinciding with electric discharges in the duodenum or terminal biliary duct, respectively, and not to affect each other.
    4) The interrelations observed between discharge and flow rate or internal pressure of the terminal biliary duct indicate that the muscles of this portion possess the function as sphincter. It is suggested, therefore, that bile excretion into the duodenal lumen is effected primarily by relaxation of the terminal biliary duct.
    5) Prostaglandin E2 has proven to behave differently toward discharges in the duodenum and terminal biliary duct, viz., facilitation in the former and inhibition in the latter. It would follow that these structures serve mutually independent functions.
    6) The effects of prostaglandins on the duodenum and the terminal portion of common bile duct are considered to stem from their direct actions on the musculatures of these regions.
    7) The findings stress importance of observations with biologically active substances in tissues in the study aimed at clarification of the biliary excretory function.
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  • Masaru TAKEUCHI
    1975 Volume 11 Issue 3 Pages 109-121
    Published: September 30, 1975
    Released on J-STAGE: July 04, 2011
    JOURNAL FREE ACCESS
    The movement of the stomach after gastrectomy was studied by cine-fluoroscopic and photo-optical technique in patients undergoing pylorus preserving gastrectomy (pyloric canal being preserved approximately 1.5 cm in 8 cases; group A) or antrum Preserving gastrectomy (pyloric antrum being preserved 3-5 cm in 16 cases; group B).
    All patients were operated on in our clinic for a benign lesion located near the angle of the stomach.
    Results:
    1) In the early postoperative period, the oral gastric remnants showed remarkable dilatation in group A. The dilatation was also observed in group B, but less prominent.
    2) For the recovery from the gastric dilatation and reappearance of gastric motility, it took much more time in group A than in group B.
    3) Co-ordinated movements across the anastomotic site were recognzied about one month after operation in group B and about two months in group A.
    4) Antiperistalsis at the preserved antrum during an early postoperative period was observed in 2 of 16 cases in group B. The antiperistalsis in the two cases turned into normo-peristalsis in about two months.
    5) From the results obtained, the preserved antrum showed an excellent func-tional drainage effect and plays an important role for the transportation of the gastric content.
    6) In conclusion, antrum preserving gastrectomy results in a good postoperative gastric motility and is an excellent operative method for the benign lesions located near the angle of the stomach.
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  • Shigeo HARA, Hiroshi SUGENO, Haruo NISHIKAWA, Toshihiro SHINTAKU, Ushi ...
    1975 Volume 11 Issue 3 Pages 123-134
    Published: September 30, 1975
    Released on J-STAGE: March 01, 2011
    JOURNAL FREE ACCESS
    The electrical activities in abomasum were studied on the normal and left abomasal displaced cows. Electromyograms were obtained using eight bipolar-needle electrodes fixed by suture in the serosal surface of the various portions of the abomasum; one in the cardia, three in the fundus, and four in the pylorus.
    The results were sumnarized as follows:
    1. In the cardia and fundus, the repetetive but irregular spikeburst was observed.
    2. In the pylorus, the single spike followed by the spike-burst was observed. These spikes were rhythmic and propagative. The propagation velocity in the pylorus was shown the tendency to increase with approach to the pyloric canall. The electomyographic pattern in the cows was similar to goats except the discharge interval was longer in cattles than in goats.
    3. The electrical activities in the abomasum received the left abomasal displacement showed the higher amplitude, the more prolonged discharge interval and accerelated propagation velocity than in controls.
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  • Takesi HUKUHARA, Yumi FUJIWARA
    1975 Volume 11 Issue 3 Pages 135-144
    Published: September 30, 1975
    Released on J-STAGE: July 21, 2010
    JOURNAL FREE ACCESS
    In catfishes the role of the intramural ganglion cells taken in the ileo-colic motilities were studied. The results obtained were summarized as follows:
    (1) When the stomach was half full of contents, the gastric peristalses recurrently occurred at the cardia, traveling caudad to come to an end at the pylorus.
    (2) In the duodenum contractions were produced here and there, traveling both caudad and orad, to mingle the contents with each other, respectively.
    (3) Along its whole length the ileum often fell in a more or less tonically contracted state, resulting in the retardation of the transfer of the duodenal contents. Furthermore, the effect described above was increased by powerful contractions which were occasionally produced here and there to travel in both directions only a short distance.
    (4) When the large intestine was moderately full of contents, powerful contractions produced in the caudal half of the ileum frequently traveled caudally to expel the contents out of the anus.
    (5) The supravital staining with methylene blue solution revealed that the myenteric plexus existed, whereas the submucous plexus did not contain the nerve cells. In the former, thick nerve bundles without forming meshworks took their course along the long axis of the intestine, accepting many finer axons coming from the nerve cells, which were not in groups, but lay sporadically, although they showed a tendency to increase their number in the area close to the nerve bundles. Any sign of the intrinsic mucosal reflex was not observed with the stimulation either of a spot (by rubbing with cotton) or of the whole surface (by raising the intraluminal pressure) of the mucosa of the intestine. These facts suggest that in catfishes the intramural ganglion cells have no function to regulate the strength as well as the direction of propagation of the contraction waves.
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