Japanese Journal of Smooth Muscle Research
Online ISSN : 1884-8788
Print ISSN : 0374-3527
ISSN-L : 0374-3527
Volume 18, Issue 5
Displaying 1-5 of 5 articles from this issue
  • 1982 Volume 18 Issue 5 Pages 313-317
    Published: November 10, 1982
    Released on J-STAGE: July 21, 2010
    JOURNAL FREE ACCESS
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  • 1982 Volume 18 Issue 5 Pages 319-329
    Published: November 10, 1982
    Released on J-STAGE: July 21, 2010
    JOURNAL FREE ACCESS
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  • Toshifumi KANAIZUMI, Kenzo Ko, Shogo MURATA, Yoichi MORIMOTO, Jiro OKA ...
    1982 Volume 18 Issue 5 Pages 331-338
    Published: November 10, 1982
    Released on J-STAGE: July 21, 2010
    JOURNAL FREE ACCESS
    The patterns of gastric emptying after selective proximal vagotomy (SPV) and SPV with pyloroplasty (SPV+D) were studied using a liquid labelled with 99mTc-DTPA.
    By means of on-line computer facility, it was possible to analyse the relative role of the Whole stomach and the antrum within the overall frame work of gastric emptying.
    In the time/activity curve of the whole stomach, all of 3 groups emptied in exponential curve. Comparing with normal subjects, SPV subjects were tending to empty slowly, while SPV+D subjects were tending to empty rapidly.
    In the time/activity curve of the antrum, normal and SPV+D subjects had two types of emptying-one was represented in the decreasing curve and another was represented in the increasing-decreasing curve. While SPV subjects had only one type of emptying which was represented in the increasing-decreasing curve.
    From a consideration of the pattern of gastric emptying curve, SPV subjects had two different emptying states compared with normal subjects-one was the delay of entering the antrum from the fundic side of stomach, and the other was that effective antral emptying did not readily start. While SPV+D kept more neally normal gastric emptying that it of SPV.
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  • Yasushi SAKAI, Santa ICHIKAWA, Masahide YOSHIDA, Michiko OOUCHI, Masam ...
    1982 Volume 18 Issue 5 Pages 339-345
    Published: November 10, 1982
    Released on J-STAGE: July 21, 2010
    JOURNAL FREE ACCESS
    Sakai, Y., Ichikawa, S., Yoshida, M., Oouchi, M. and Miyagawa, M. ATPase Activity and Calcium Uptake of Microsomes Isolated from Stomach Smooth Muscle after Exposure to Phospholipase C. Japanese J. Smooth Muscle Res., 1982, 18, (5), 339-345. ATPase activity and Ca2+ uptake were examined in microsomal membrane fractions isolated from guinea pig stomach smooth muscle which had been exposed to phospholipase C (PLC). Basal Mg2+-ATPase, Na+, K+-ATPase and Ca2+, Mg2+-ATP activities were inhibited in a time dependent manner by PLC treatment. There was positive correlatioon between each of these ATPase activities and total phospholipid content of the microsomal fraction. Phosphotidylcholine restored Ca2+, Mg2+-ATPase activity of the microsomal fraction isolated from the tissue which had been treated with PLC for 30min but not after 60min. Ca2+ uptake in the presence of ATP by microsomal fraction from tissue treated with PLC for 60min was significantly decreased. The results provide a cellular basis for the inhibitory effect of PLC on contractility of stomach smooth muscle.
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  • Hiroshi IKADAI, Kazumasa SHIMIZU, Shinjiro NAKAJYO, Tomonori IMAMICHI, ...
    1982 Volume 18 Issue 5 Pages 347-361
    Published: November 10, 1982
    Released on J-STAGE: July 21, 2010
    JOURNAL FREE ACCESS
    The shortenings of intestinal strips isolated from narrow segments in the aganglionosis rat have been studied in response to stimulants and field stimulation. Relating to the action of nicotine, eserine and field stimulation, the number of exogenous nerve bundles observed between the longitudinal and circular muscle layer and the type of cells existing in the nerve bundles were examined by light and electron microscopes.
    Nicotine shortened in 16 out of 31 narrow segments and eserine 13 out of 14 preparations. In 6 out of 21 preparations, field stimulation produced weak contraction, which was abolished by pretreatment of atropine or TTX. The number of the nerve bundles was larger in the responded groupes than in the non-responded. However, no ganglion cells were observed in the nerve bundle of the narrow segment of the aganglionosis rat.
    To acetylcholine, serotosine, prostaglandine E2, KCl and BaCl2, all narrow sements responded, though the response to these drugs particulary to KCl was extremely weaker than those in control.
    It is suggested that the nerve bundles of the narrow segment branched and formed nerve endings in the smooth muscle and the responsiveness of the receptor to the stimulants is maintained in the narrow segment, but contractility of the smooth muscle is small.
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