Nickel is set to play a pivotal role in the next chapter of energy storage. Over the next decade, nickel-based Li-ion batteries are expected to dominate the battery market for both energy storage systems (ESS) and electric vehicles. One of the key features of nickel-based active materials is their morphology; the shape and size of the particles can affect the electrochemical performance of the active materials. Both nickel-containing anode and cathode materials with excellent morphology have been reported to have high capacity, excellent cycle stability, and rate-ability. These key performance metrics demonstrate the promising future for the development of a clean and sustainable energy industry.
Pharmaceutical dry powders with desired aerosol properties are required for efficient pulmonary drug delivery. Thin-film freezing (TFF) followed by lyophilization is a particle engineering technology that produces highly porous, brittle, powder matrices with excellent aerosol properties and high drug loading. In this review article, the authors describe the TFF technology and discuss the physical and aerosol properties of TFF powders as well as factors affecting those properties. Finally, the authors provide a comprehensive review of published literature for applying the TFF technology to prepare aerosolizable dry powders of protein-based pharmaceuticals for pulmonary delivery.
Single-particle breakage studies were, in the not-so-distant past, only of academic interest, since no tools were available to transfer the microscale information they provide to deal with problems in industry. Fortunately, the discrete element method (DEM), along with properly-formulated population balance models, not make it possible to carry information from single particles to predict the performance of crushers, mills and handling systems that may cause their mechanical degradation. The work critically analyzes one model that has been found quite powerful in this task.
Delivery systems using nanoparticles and microparticles composed of biodegradable polymers such as polylactic glycolic acid have attracted much attention in the pharmaceutical and cosmetic fields to the delivery of active ingredients into the body. This paper describes a novel microparticle preparation method using fine-charged droplets as reaction fields generated by electrospray. This method is unique and impactful because tailored PLGA microspheres with various sizes and different structures such as porous and solid structures can be prepared by controlling the process conditions. The formation mechanism of particles with different sizes and structures within the droplets is also explained.
Due to their easy handling, transport, and storage compared to liquids and gases, solid products in particulate form are of great interest in both, daily life and industrial applications. Along with the high demand for those products comes the need for a thorough understanding of particle production and modification processes, like fluidized bed spray granulation, to achieve the desired product properties. To contribute to that process understanding and to, in the long term, enable the production of tailor-made particles, this study aims to correlate process parameters and particle surface structure in fluidized bed spray granulation.
On the Relationship between Torque and Flow Structure in Powder Mixers
Released on J-STAGE: May 30, 2014 | Volume 19 Pages 118-130
Bruno Laurent, John Bridgwater
A Review of the Fire and Explosion Hazards of Particulates
Released on J-STAGE: February 27, 2014 | Volume 31 Pages 53-81
Saul M. Lemkowitz, Hans J. Pasman