症例は77歳，男性．急性腹症のため救急搬送され，造影CTにて左総腸骨動脈瘤破裂と診断し，緊急手術を施行した．腎動脈下から大動脈分岐までの距離が55 mmと短く，IFU（instruction for use）外であったが，Doube D Technique（DDT）を用いたステントグラフト内挿術を施行した．術後4時間後に腹部コンパートメント症候群をきたし開腹減圧術を追加した．術後2日目に後腹膜血腫除去術と閉腹術を施行した．術後3日目，左脚のType Ibエンドリークを認め，左脚を追加した．以降エンドリークなく経過している．腹部大動脈瘤破裂に対するステントグラフト内挿術は年々増加しており，解剖学的要件を満たしていれば第一選択とされている．開腹手術に比して低侵襲であり，同等以上の成績が報告されており，今後適応の拡大が予想される．DDTはIFU外の破裂症例に対しても有用な代替手段と考える．

抄録全体を表示

【目的】腹部大動脈瘤（AAA）などに対するendovascular aneurysm repair（EVAR）において，企業製分岐型ステントグラフト（SG）の使用が問題となる解剖学的不適合症例に対し考案した，

technique（DDT）の有用性を報告する．【方法】2012～2014年にDDTを行った6例を後方視的に調査．【結果】平均年齢73.5歳，男性4例．疾患はAAA破裂1例，両側総腸骨動脈瘤2例，Aortoiliac occulusive disease 2例，解離性大動脈瘤1例．DDT施行理由は大動脈分岐部狭小3例，両側内腸骨動脈塞栓に伴う下腸間膜動脈血流温存目的2例，解離性大動脈瘤真腔狭小化1例．手技的成功100%，一次脚閉塞率16.6%，二次脚閉塞率0%．endoleak 0%．【結論】企業製分岐型SG解剖学的不適合症例に対してDDTは有用な代替手段と考える．

抄録全体を表示

Compare with circular coils,

- coils are widely used in the wireless charging system of electric vehicles for its high coupling coefficient and excellent offset tolerance. In order to obtain higher coupling coefficient and reduce the leakage magnetic flux in the central part of the coils, this paper proposes a method that optimizing stray parameters, which can achieve more than 95% of transmitting efficiency. The investigation is performed by joint simulation for the choice of experimental devices concerning current-withstanding characteristic. According to simulations and experiments, more than 11 kW output power can be achieved for a wide range of frequency.

抄録全体を表示

An eddy current testing (ECT) coil system including a - coil as a pickup coil and a ring coil as an axisymmetric excitation coil was modeled. (Despite the frequent use of a - coil in ECT probes as an excitation coil, we employed it as a pickup coil). A - coil made from two semicircular wires connected in counter-series was placed within a ring coil in such a way that the coils were coaxial and co-planar. The structure of the coil system makes it insensitive, in principle, to a magnetic field with an axisymmetric distribution and sensitive to any unbalanced field. The method presented here is based on the numerical calculation of the well-known expression for the vector potential due to a ring coil, developed by Dodd and Deeds. Using this method, the induced voltage in the - coil due to flaw-eddy current interaction was numerically evaluated on numerous grids placed over the surface of an aluminum plate. In this way we plotted the measured voltage versus the radial distance between the centers of the probe and the flaw. By investigating the plot we can characterize the flaw. The experimental results agree very well with the results of numerical calculation.

抄録全体を表示

Recent X-ray crystallography studies on fragments D and DD from fibrinogen and fibrin have revealed the nature of the interaction at the ends of the individual fibrin units. Additionally, cocrystallization of fragments with synthetic peptides patterned on the sequences exposed by the thrombin-catalyzed removal of the fibrinopeptides has provided the details of knob-hole interactions. Interestingly, fragments complexed with the synthetic peptide corresponding to the B knob (GHRPam) exhibit a large conformational change in the presence of the ligand, adding to the intrigue of the still not well understood role of fibrinopeptide B removal.

抄録全体を表示

大動脈腸骨動脈閉塞症に対してCovered Endovascular Reconstruction of the Aortic Bifurcation（CERAB）テクニックを用いた血管内治療が数多く報告されている．今回われわれは20 mでの重度間欠性跛行を呈したLeriche症候群を経験した．CTにおいて左右腎動脈分岐の高さが異なり右腎動脈分岐部で腹部大動脈は80%狭窄を呈し20 mm下位の左腎動脈分岐部で腹部大動脈は閉塞しており，閉塞部は両側外腸骨動脈末梢まで及んでいた．Kissing stentテクニックで治療すると留置の高さにずれが生じるためCERABテクニックで治療した．今回のCERABテクニックは末梢血管用ステントグラフトおよびステントのみを用いて

テクニックを併用し留置した．現在グラフトは再治療介入する事なく開存しており，症状再燃なく術後1.5年が経過している．

抄録全体を表示

We report the case of a 83-year-old man with aneurysmal sac enlargement after endovascular aneurysm repair for an abdominal aortic aneurysm, despite no overt endoleak (EL) detected on imaging. Occult type II EL was suspected, and treatment was performed. However, the aneurysm continued to enlarge. Thus, we diagnose with type V EL as exclusion diagnosis. We combined an aortic cuff and stent-graft leg to cover the initially inserted stent graft, as a diagnostic treatment for unrefined type IIIb EL. Subsequently, the aneurysm diameter decreased. This technique and concept may be effective for type V EL, which may include another type occult EL.

抄録全体を表示

A joining technology is necessary for the manufacturing process of CFRTP composite structures. This study aims to reveal the induction welding behavior of CFRTP composites by high-frequency induction heating method. The material used is woven-CF/PPS laminate. The

type coil was used was for induction heating. The effects of coil moving speed, high-frequency power on the heating behavior of CFRTP composites and the influence in induction heating were investigated. The experimental results revealed that the surface temperature of woven-CF/PPS laminates was increased with increasing the high-frequency power and decreased as the coil moving speed increased. Moreover, the surface treatment could be suppressed with the cooling method. The coil was used calling type coil. The effects of high-frequency power and coil moving speed, and cooling method were investigated, the optimum condition was obtained to improve. The results of single lap tensile test, the strength was obtained at 42MPa when the high-frequency power was 475-550W.

抄録全体を表示

感染性動脈瘤に対する基本治療は抗菌薬投与とopen surgeryによる感染組織の広範囲除去と血行再建で，ステントグラフト治療は相対的禁忌とされ，根治術までのbridgeと考えられてきた．しかし近年では感染性動脈瘤に対しステントグラフト治療のみで救命できた症例報告が散見される．症例は73歳男性．胸部大動脈囊状瘤に対する2-debranching+single chimney thoracic endovascular aortic repair施行2年目に感染性仮性腕頭動脈瘤を発症した．VIABAHNを用い

techniqueで破裂予防措置を行い，結果的に救命できた症例を経験したため報告する．

抄録全体を表示

50歳，女性．異型大動脈縮窄症（III型）に対し33年前に上行大動脈－腹部大動脈バイパス手術を施行．5年前にバイパスに使用した人工血管の非吻合部嚢状瘤に対してステントグラフト内挿術（TEVAR）施行．今回，前回とは別の部位の人工血管非吻合部拡張と腹部大動脈との吻合部仮性嚢状動脈瘤，両側腎動脈起始部狭窄とを指摘，吻合部仮性嚢状動脈瘤に関して手術適応と判断した．年齢より再開腹下根治手術を考慮したが，術前造影CTにおいて，下腸間膜動脈（IMA）から腹腔動脈（CeA）・上腸間膜動脈（SMA）へ豊富な側副血行路が発達しており，再開腹症例で癒着も想定され，その側副血行路損傷による出血はもとより，腹部全虚血となるリスク等を考慮し，開腹手術はハイリスクと考えられたため，Hybrid手術を計画．両側腋窩動脈－外腸骨動脈バイパス＋中枢吻合部take down＋腹部ステントグラフト内挿術（modified

Technique）＋瘤内コイル充填術を行い，エンドリークを残さず手術を終了．POD 13に両側腎動脈にバルーン拡張を追加しPOD 37自宅退院．2.5年経過後も特に問題なく外来通院中である．

抄録全体を表示

To maintain and to differentiate into various plastid lineages, replication of the plastid DNA (ptDNA) and division of the plastid must take place. However, replication initiation of the ptDNA has been less understood. The present study describes identification of the initiation region (origin) of ptDNA replication in the rice cultured cells. RNA-primed newly replicated DNA strands pulse-labeled with bromodeoxyuridine were isolated and size-fractionated. Locations of these nascent strands on the ptDNA determined the two major origin regions around the 3' region of each 23S rDNA in the inverted repeats (IR_A and IR_B). Two-dimensional agarose gel electrophoresis of the replication intermediates suggested that replication from each origin proceeds bidirectionally. This contrasted to replication by the -loop mechanism.

抄録全体を表示

The manufacturing process of Carbon fiber reinforced thermoplastic (CFRTP) composite structures is manufactured at high temperature and high pressure using a commercial mold, and then an intergraded molding is undesirable for large-sized structures with complex shape. Therefore, a joining process is necessary for manufacturing of CFRTP composite structures. CFRTP is able to fusion joining using thermal properties. This study aims to reveal the induction welding behavior of CFRTP composites by high-frequency induction heating method. The material used is woven-CF/PPS laminate and woven-CF/PES laminate. The

type coil was used was for induction heating. The effects of high-frequency power the influence in induction welding were investigated. The experimental results revealed the induction heating temperature and single lap shear strength during induction welding.

抄録全体を表示

The manufacturing process of Carbon fiber reinforced thermoplastic (CFRTP) composite structures is manufactured at high temperature and high pressure using a commercial mold, and then an intergraded molding is undesirable for large-sized structures with complex shape. Therefore, a joining process is necessary for manufacturing of CFRTP composite structures. CFRTP is able to fusion joining using thermal properties. This study aims to reveal the induction welding behavior of CFRTP composites by high-frequency induction heating method. The material used is woven-CF/PPS laminate. The

type coil was used was for induction heating. The effects of high-frequency power and pressure of pressure roller the influence in induction welding were investigated. The experimental results revealed the temperature change of the joining part at the time of induction welding of woven-CF/PPS laminates. And, As a result of cross-sectional observation, edge effects were confirmed. Also, the surface roughness, the laminate thickness and the single rap shear strength was decreased with increasing the pressure of pressure roller.

抄録全体を表示

経頭蓋磁気刺激とはコイルから発生する磁場により，脳内に電場を誘導し，脳を刺激する脳神経疾患の低侵襲な治療法の一つである．我々は経頭蓋磁気刺激の新しい刺激コイル，ダブルDコイルを作製した．本コイルは，従来コイルと同等の印加電流，駆動装置を用いたまま，位置がずれた際であっても標的に誘導される電場が変わらず安定的に刺激できるよう，シミュレーションに基づき設計したものである．本研究では，被験者5名の脳を刺激し，作製したダブルDコイルのコイル位置を故意にずらした際の運動誘発電位の影響を評価することを目的とした． 比較には商用の８の字コイルを用い，各々のコイルを用いて左脳の一次運動野周辺を200点刺激し，各刺激箇所における右手の第一背側骨間筋の運動誘発電位を測定した．運動誘発電位は頭部での位置と対応するよう，グラフ上にマッピングし，最小二乗法を用いて二変量ガウス関数上にフィッティングを行った．得られたガウス関数の長軸，短軸の二方向で運動誘発電位の半値幅を算出した．短軸方向には全ての被験者で半値幅の拡大が見られ，平均で1.6倍となった．長軸方向では，ダブルDコイルを十分に移動することが出来なかった一被験者を除き，全ての被験者で半値幅の拡大を確認し，全被験者の平均でも1.5倍となった．ダブルDコイルが８の字コイルに比べてコイル位置による運動誘発電位の影響が小さいことを明らかとした．

抄録全体を表示

Misatol GLをSD系ラット雌雄に単回及び90日間反復経口投与し，安全性について評価した．単回経口投与において，Misatol GL原液を5, 10及び15 mL/kgの用量で単回経口投与した結果，5 mL/kgでは異常は認められず，10及び15 mL/kgで一過性の水様性下痢が認められた．90日間の反復経口投与において，Misatol GLを1.25, 2.5及び5 mL/kg/dayの用量で投与した結果，雄のMisatol GL 1.25 mL/kg/day投与群及び5 mL/kg/day投与群及び雌のMisatol GL 2.5 mL/kg/day投与群及び5 mL/kg/day投与群において，軽微な摂餌量の低下が，雄のMisatol GL 1.25 mL/kg/day投与群及び5 mL/kg/day投与群において，軽微な前胃の空胞化が認められたが，いずれも毒性学的な意義は低いと考えられた．一般状態，体重，尿検査，眼科学的検査，血液検査，剖検及び器官重量において，Misatol GLに起因する変化は認められなかった．したがって，Misatol GLの安全性は高いと考えられた．

抄録全体を表示

放射線不透過マーカーを用いて大腸通過時間を測定し，便秘の質的診断を試みた．健常成人ボランティア43名を対象とし，1，2，3日目に放射線不透過マーカー（Sitzmarks）を服用，4，7日目に腹部単純写真を撮影，Metcalfらの方法で全大腸通過時間，大腸各区域（右側，左側，S状結腸直腸）通過時間を測定した．質問アンケートと排便状況（回数，ブリストルスケール）について自記させた．通過時間は中央値で示した．男性（n=13）はすべて便秘（-）で，全大腸通過時間は7.2h，右側2.4h，左側3.6h，S状結腸直腸2.4h．女性で便秘（-）（n=24）は全大腸31.8h，右側4.2h，左側9.0h，S状結腸直腸11.4h．女性で便秘（+）（n=6）は全大腸110.4h，右側30.6h，左側36.6h，S状結腸直腸30.0hであった．大腸通過時間が40h超の延長例を類型化すると，左側通過時間を最長とするcolonic inertia型とS状結腸直腸通過時間を最長とするoutlet obstruction型に分類できた．この分類は排便回数やブリストルスケールでは判別できず，放射線不透過マーカーによる質的診断の有効性が示唆された．

抄録全体を表示

The present authors have investigated the changes in adhesion of electroless Ni–P plated films on an aluminum alloy substrate (JIS A2017P-T3, Al–4 mass%Cu) from the viewpoint of the preceding zincate treatment and the subsequent heat treatment. The precipitation state of zinc and adhesion of Ni–P plated film differed with the number of zincate treatments. Without zincate treatment, some of the Ni–P plated film peeled off during the plating process, and the film obtained after the single zincate treatment also showed poor adhesion to the substrate. The highest adhesion was obtained by the double zincate treatment, and the triple zincate treatment resulted in a poorer adhesion. Existence of aluminum at the surface of the zincate film was shown to be necessary to obtain higher adhesion of the Ni–P plated film, on the other hand, excess zinc obtained by the triple zincate caused lower adhesion. Interdiffusion of aluminum and nickel between the Ni–P plated film and the substrate through the medium of zincate film with an appropriate thickness is thought to promote strong bond between the Ni–P plated film and the substrate.

抄録全体を表示

This paper presents a method for measuring the iron loss of ferrite cores under compressive stress. Moreover, a novel methodology is proposed for analyzing the local heat generation of ferrite cores for wireless power transfer by considering an increase in the iron loss because of compressive stress. The effectiveness of the proposed analysis method is experimentally verified.

抄録全体を表示