Isolation and Synthesis of Cosmetic Substances from African Dietary Leaves, Celosia argentea L. for Skin Depigmentation

Akiyoshi SAWABE; Masato NOMURA; Yoshihito FUJIHARA; Takahiro TADA; Fumihiro HATTORI; Satoko SHIOHARA; Kenji SHIMOMURA; Yoshiharu MATSUBARA; Sadao KOMEMUSHI; Tadashi OKAMOTO; Saburou KAWAMURA

doi:10.5650/jos.51.203

NOTES

Isolation and Synthesis of Cosmetic Substances from African Dietary Leaves, Celosia argentea L. for Skin Depigmentation

Akiyoshi SAWABE, Masato NOMURA, Yoshihito FUJIHARA, Takahiro TADA, Fumihiro HATTORI, Satoko SHIOHARA, Kenji SHIMOMURA, Yoshiharu MATSUBARA, Sadao KOMEMUSHI, Tadashi OKAMOTO, Saburou KAWAMURA

著者情報

キーワード: citrusin C, eugenyl O-β-D-glucopyranoside, skin depigmentation effect, tyrosinase inhibitory activity, superoxide scavenging activity

ジャーナルフリー

2002 年 51 巻 3 号 p. 203-206

DOI https://doi.org/10.5650/jos.51.203

詳細

抄録

Six compounds were isolated from the leaves of Celosia argentea L.. Tyrosinase inhibitory and superoxide scavenging activity of the compounds was examined so as to obtain a skin depigmentation agent for cosmetic application. Eugenyl O-β-D-glucopyranoside (citrusin C, 1) showed strong tyrosinase inhibitory activity. Two-step inhibitory effects of successive tyrosine and DOPA oxidation for tyrosinase were stronger compared to arbutin used commercially at present (47.20% inhibition of tyrosine oxidation and 87.93%, DOPA oxidation, compared to 63.00% for tyrosine and 7.70% for DOPA oxidation in the case of arbutin). Moreover, we succeed in providing compound 1 abundantly in the synthetic study which used acetobromo-α-D-glucose and Sn(OTf)₂.

責任著者(Corresponding author)

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