抄録
Plant sterols are effective inhibitors of cholesterol absorption. Examination was made of the physiological effects of plant sterols and/or mayonnaise on this inhibition in rats. Male Wistar rats were divided into four groups (Control, PS, MS, MS+PS) and provided experimental diets for three weeks. The diets of two groups (PS, MS+PS) contained 0.5% plant sterols with or without 2% mayonnaise, while those of the other two groups (Control, MS) did not contain the sterols. PS and MS+PS groups had lower serum and hepatic cholesterol concentrations, and had higher serum HDL-cholesterol concentration than Control and MS groups. Fecal excretion of neutral sterols was noted to increase in PS and MS+PS groups. Plant sterols persisted even when the sterols had been mixed with mayonnaise. The mayonnaise addition may thus be concluded to have no effect on the inhibitory action of plant sterols which in this study were found to reduce serum and hepatic cholesterol concentrations.
