Synthesis and Antimicrobial Activity of Quaternary Ammonium Silane Coupling Agents

Norio Yoshino; Shigenori Sugaya; Toshimitsu Nakamura; Yoh-hei Yamaguchi; Yukishige Kondo; Kazuo Kawada; Toshio Teranaka

doi:10.5650/jos.60.429

Biochemistry and Biotechnology

Synthesis and Antimicrobial Activity of Quaternary Ammonium Silane Coupling Agents

Norio Yoshino, Shigenori Sugaya, Toshimitsu Nakamura, Yoh-hei Yamaguchi, Yukishige Kondo, Kazuo Kawada, Toshio Teranaka

著者情報

キーワード: silane coupling agents, antimicrobial activity, surface modification, quaternary ammonium salts, minimum inhibitory concentrations

ジャーナルフリー

2011 年 60 巻 8 号 p. 429-438

DOI https://doi.org/10.5650/jos.60.429

詳細

抄録

Fourteen novel silane coupling agents with a quaternary ammonium group introduced into the molecule, [CH₂=CHCH₂N⁺(CH₃)(C_nH_2n+1)(CH₂)₃Si(OCH₃)₃]X^- (n-X, n=10–18, X=Cl, Br, or I), were synthesized with the aim of using these agents to make material surfaces antimicrobial for a long period of time. Measurements of the minimum inhibitory concentrations (MIC) against 12 kinds of fungi and bacteria revealed that the coupling agent with a C₁₀ alkyl chain and Cl- or Br- counter-ion (10-Cl or 10-Br) has the highest antimicrobial activity among the n-X agents synthesized, but 14-Cl and 14-Br showed the highest activity on a modified porcelain plate.

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