Interaction between Hydrophilic Ionic Liquid and Phospholipid/Cholesterol Mixed Film

Kotaro Kaneko; Aki Nakazato; Akihiro Ishikawa; Nobuhiro Kaneko; Akira Yashita; Masaaki Akamatsu; Kenichi Sakai; Hideki Sakai

doi:10.5650/jos.ess21261

Detergents, Surfactants, Interface and Colloid

Interaction between Hydrophilic Ionic Liquid and Phospholipid/Cholesterol Mixed Film

Kotaro Kaneko, Aki Nakazato, Akihiro Ishikawa, Nobuhiro Kaneko, Akira Yashita, Masaaki Akamatsu, Kenichi Sakai, Hideki Sakai

著者情報

Kotaro Kaneko
Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science
Miyoshi Oil & Fat Co., Ltd.
Aki Nakazato
Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science
Akihiro Ishikawa
Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science
Nobuhiro Kaneko
Miyoshi Oil & Fat Co., Ltd.
Akira Yashita
Miyoshi Oil & Fat Co., Ltd.
Masaaki Akamatsu
Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science
Kenichi Sakai
https://orcid.org/0000-0003-4038-8954
Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science
Research Institute for Science and Technology, Tokyo University of Science
Hideki Sakai
Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science
Research Institute for Science and Technology, Tokyo University of Science

キーワード: hydrophilic ionic liquid, phospholipid, cholesterol, surface pressure-area (π-A) isotherm, fluorescence anisotropy

ジャーナルオープンアクセス
電子付録

2022 年 71 巻 1 号 p. 67-74

DOI https://doi.org/10.5650/jos.ess21261

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詳細

抄録

Surface pressure (π)-area (A) isotherms were studied to analyze the interactions between a hydrophilic ionic liquid (IL) (ethyl(2-hydroxyethyl)dimethylammonium methanesulfonate) and a pure dipalmitoylphosphatidylcholine (DPPC) film or a DPPC-cholesterol mixed film. When the hydrophilic IL was added to an underlayer solution, the isotherm shifted toward higher areas. Intriguingly, when the hydrophilic IL was added, the packing of the film materials became loose and the elastic modulus decreased, resulting in increased flexibility. This phenomenon was most evident under a cholesterol mole fraction of 0.2. This composition resembles that of cell membranes, which typically comprise phospholipids and cholesterol, suggesting that this hydrophilic IL may be able to interact significantly with biological membranes.

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