凍り豆腐の脂質代謝・糖質代謝改善効果とそのメカニズム

抄録

Kori-tofu is a traditional food in Japan. Kori-tofu is known to decrease serum LDL-cholesterol and triacylglycerol. Kori-tofu also decreases HbA1c, indicating improved sugar metabolism. A dominant hypothesis regarding these phenomena is that the undigested protein fraction of kori-tofu (resistant protein) binds to bile acids in the intestine, preventing bile acid resorption. Recent studies have shown that bile acids are a type of signaling molecule that activates FXR and TGR5. This can explain why the binding activity of bile acid, involving resistant protein, relates to lipid and sugar metabolism. Resistant protein in kori-tofu is increased during its production process, including high-pressure treatment of fresh tofu, freezing and low-temperature aging. The abundance of resistant protein can explain the function of kori-tofu.