Biological and Pharmaceutical Bulletin
日本薬学会は,1880年に創立された,我が国では歴史ある学会の一つです.現在,約15,000人の会員を擁しており,毎月3誌の学術誌を刊行しております.英文による学術誌の一つとして「Chemical and Pharmaceutical Bulletin」(Chem. Pharm. Bull.)は, 1953年にPharmaceutical Bulletinとして創刊され,その後Chem. Pharm. Bull. と名称を変え,薬学と健康科学に関する化学分野をカバーしています.二つ目として,「Biological and Pharmaceutical Bulletin」(Biol. Pharm. Bull.) があり,これは1978年に創刊されたJournal Pharmacobio-Dynamicsを起源としており,更に1953年に創刊され,2012年に内容を引き継いだJournal of Health Scienceの後継誌として,薬学と健康科学に関する生物学分野を領域としています.英文と和文両方にて構成される学術誌として,「YAKUGAKU ZASSHI」(薬学雑誌)があり,本学術誌は学会創立の翌年(1881年)に創刊され,最も長い歴史を有しています.薬学雑誌では,和文による原著論文・総説等のほか,臨床薬学領域研究については英文による投稿も受け付けています. 日本薬学会におけるこれら学術誌のスコープは,基礎研究から臨床研究に至る幅広い分野に渡りますが,いずれも薬学・健康科学をベースとしています。3誌に投稿された論文の平均審査期間は,現在,投稿された方へ最初の判定を通知するまでに約1か月ですが,更なる時間短縮を目指しています.3誌ともにJ-STAGEにて無料公開しており,研究成果を世に広める一助となることを期待しております.皆様の研究成果をChem. Pharm. Bull.やBiol. Pharm. Bull.,薬学雑誌へ積極的にご投稿下さいますよう,よろしくお願い申し上げます.

学術誌編集委員長
中川 秀彦
名古屋市立大学大学院薬学研究科
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収録数 11,717本
(更新日 2025/07/13)
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
1.7
2024 Journal Impact Factor (JIF)
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48 巻 (2025) 5 号 p. 537-544
Efficacy of De-Escalation to Cefmetazole in Patients with Bacteremic Urinary Tract Infections Caused by Extended-Spectrum β-Lactamase-Producing Escherichia coli もっと読む
編集者のコメント

The pharmacokinetic/pharmacodynamic (PK/PD) parameter of the exposure time that the unbound drug concentration remains above the minimum inhibitory concentration (MIC) for a bacterium (fT ≥ MIC) is used in establishing optimal dosing regimens. The authors revealed that the optimal fT ≥ MIC for the clinical efficacy of de-escalation to cefmetazole (CMZ) for patients with extended-spectrum β-lactamase-producing Escherichia coli (ESBL-E) bacteremic urinary tract infection (UTI) was clarified as fT ≥ MIC ≥ 57%. These results may lead to optimal dosing regimens when using CMZ for patients with bacteremic UTI caused by ESBL-E.

48 巻 (2025) 5 号 p. 545-554
Role of Histamine H1 and H3 Receptors in Emotion Regulation in Intermittent Sleep-Deprived Mice もっと読む
編集者のコメント

Abnormal behaviors such as low anxiety, impulsivity, hyperactivity, and inattention-like traits have been observed in mice with disrupted sleep patterns, mirroring symptoms of attention deficit hyperactivity disorder (ADHD) and the central histamine system plays a role in various physiological and neurological functions, including the regulation of the sleep-wake cycle, anxiety-related behaviors (ranging from high to low anxiety), and ADHD. In this study, the authors revealed that the low-anxiety behavior and impulsive-like ADHD symptoms induced by intermittent sleep deprivation may result from the overstimulation of histamine H1 and H3 receptors by elevated histamine together with increased hypothalamic HDC expression.  These findings suggest that sufficient sleep may contribute to ameliorating ADHD symptoms.

48 巻 (2025) 5 号 p. 606-612
Impact of Bridged Nucleic Acid Positions within Blocking Oligonucleotides on DNA Amplification Inhibition in Wild-Type Blocking PCR もっと読む
編集者のコメント

[Highlighted Paper selected by Editor-in-Chief] 
Detecting low-frequency genetic mutations is crucial in genetic testing, particularly for cancer diagnostics. Wild-type blocking PCR (WTB-PCR) utilizes a blocking oligonucleotide fully complementary to wild-type DNA to suppress its amplification, thereby enabling selective detection of mutant alleles. Incorporating bridged nucleic acids (BNAs) into blocking oligonucleotides can enhance binding affinity, consequently improving inhibitory efficiency. However, the optimal placement of BNAs within blocking oligonucleotides remains uncertain. This study systematically evaluated the effects of BNA positioning and identified significant variations in inhibition efficacy dependent on position, offering essential insights for optimizing WTB-PCR design.

48 巻 (2025) 5 号 p. 672-681
Protective Effects of Pleurotus Species on UVB-Induced Skin Disorders at Clinically Relevant Plasma Concentrations of the Antioxidant Ergothioneine in Hairless Mice もっと読む
編集者のコメント

Ergothioneine (ERGO), an amino acid with potent antioxidant activity, is abundantly found in certain mushroom species. The authors demonstrated that dietary ERGO-rich mushrooms significantly alleviated the epidermal thickening, reduction in skin moisture content, and increase in TEWL induced by UVB in mice, at clinically relevant plasma ERGO levels. These protective effects were accompanied by reductions in oxidative stress markers and pro-inflammatory cytokines. Furthermore, ERGO-rich mushroom intake increased epidermal ERGO levels to approx. 100 times the concentration required to inhibit UVB-induced intracellular ROS in keratinocytes. These findings suggest that ERGO-rich mushrooms are promising beneficial foods for the prevention and/or treatment of photoaging.

48 巻 (2025) 5 号 p. 706-712
Evaluating Signal Peptide Efficiency for Extracellular Protein Secretion for mRNA Vaccine Design もっと読む
編集者のコメント

This study systematically compares natural and synthetic signal peptides for boosting extracellular NanoLuc luciferase secretion in HEK293, C2C12, and HepG2 cells. Signal peptides from cystatin S, lactotransferrin, tissue plasminogen activator (tPA), and artificial sequences were tested, with cystatin S driving the highest luciferase secretion in all cell types. Notably, the cystatin S peptide outperformed the commonly used tPA signal peptide. These findings suggest that optimizing signal peptides—such as using cystatin S—could increase antigen expression for mRNA vaccines, potentially enabling robust immune responses at lower mRNA doses.

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発行機関からのお知らせ
  • 2024 Announcement of Academic Journals’ Awards Biological and Pharmaceutical Bulletin (BPB)https://bpb.pharm.or.jp/award/bpb_award.pdf
  • Biol. Pharm. Bull. Vol. 48 No. 3
    Current Topics: Recent Advances in Antibacterial Resistance by Japanese Pharmaceutical Scientists
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