Biological and Pharmaceutical Bulletin
日本薬学会は,1880年に創立された,我が国では歴史ある学会の一つです.現在,約18000人の会員を擁しており,毎月3誌の学術誌を刊行しております.英文による学術誌の一つとして「Chemical and Pharmaceutical Bulletin」(Chem. Pharm. Bull.)は, 1953年にPharmaceutical Bulletinとして創刊され,その後Chem. Pharm. Bull. と名称を変え,薬学と健康科学に関する化学分野をカバーしています.二つ目として,「Biological and Pharmaceutical Bulletin」(Biol. Pharm. Bull.) があり,これは1978年に創刊されたJournal Pharmacobio-Dynamicsを起源としており,更に1953年に創刊され,2012年に内容を引き継いだJournal of Health Scienceの後継誌として,薬学と健康科学に関する生物学分野を領域としています.英文と和文両方にて構成される学術誌として,「YAKUGAKU ZASSHI」(薬学雑誌)があり,本学術誌は学会創立の翌年(1881年)に創刊され,最も長い歴史を有しています.薬学雑誌では,和文による原著論文・総説等のほか,臨床薬学領域研究については英文による投稿も受け付けています. 日本薬学会におけるこれら学術誌のスコープは,基礎研究から臨床研究に至る幅広い分野に渡りますが,いずれも薬学・健康科学をベースとしています。3誌に投稿された論文の平均審査期間は,現在,投稿された方へ最初の判定を通知するまでに約1か月ですが,更なる時間短縮を目指しています.3誌ともにJ-STAGEにて無料公開しており,研究成果を世に広める一助となることを期待しております.皆様の研究成果をChem. Pharm. Bull.やBiol. Pharm. Bull.,薬学雑誌へ積極的にご投稿下さいますよう,よろしくお願い申し上げます.

細谷 健一

収録数 10,096本
(更新日 2020/02/19)
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
2018 インパクトファクター
ジャーナル 査読 フリー HTML 早期公開
43 巻 (2020) 2 号 p. 195-206
Toxicological Property of Acetaminophen: The Dark Side of a Safe Antipyretic/Analgesic Drug? もっと読む

Acetaminophen (paracetamol, N-acetyl-p-aminophenol; APAP) is undoubtedly a well-recognized and highly used antipyretic/analgesic in the world. However, some experts have misunderstood that APAP is a type of non-steroidal anti-inflammatory drugs (NSAIDs) with weak-to-moderate effects, since the adverse reaction profiles of APAP described in package insert in Japan are almost the same as classical NSAIDs. Even clinicians and researchers might actually have a wrong perception regarding it. The review by Ishitsuka et al. the safety profiles of APAP particularly in terms of respiratory tract and ductus arteriosus-related toxicity. We also introduce some recent findings about molecular mechanisms of APAP hepatotoxicity.

43 巻 (2020) 2 号 p. 215
Foreword もっと読む

Microbes are important for pharmacists, biologists, and chemists, because some environmental microbes cause infectious diseases, but also produce beneficial compounds for our health. Understanding environmental microbes are necessary to live with them and also contributes to preventing infectious diseases. This current topic summarized the recent progress on controlling environmental pathogenic microbes by disinfection methods, sterilization methods, vaccines, antibiotics, and developing new technologies.

43 巻 (2020) 2 号 p. 284-288
A Pilot Clinical Study on Thiamine Hydrochloride as a New Mosquito Repellent: Determination of the Minimum Effective Dose on Human Skin もっと読む

Mosquitoes that spread everywhere not only cause irritation, redness and discomfort after biting, but also can transmit contagious diseases. Many insect repellents have been used for decades, but were found either toxic or ineffective. Thiamine hydrochloride which is a water soluble vitamin was claimed to have certain insect repellent activity. However, there is a demand for a reassessment of the minimum required dose that is sufficient to perform a topical repellency on the human skin. The article by Badawi et al. estimated a dose response line through “probit plane analysis”. The repellent dose corresponding to percent protection of 50% and 99.9% was determined and validated.

43 巻 (2020) 2 号 p. 325-333
Pharmacological Properties of JTE-952, an Orally Available and Selective Colony Stimulating Factor 1 Receptor Kinase Inhibitor もっと読む

Colony stimulating factor 1 (CSF1) receptor (CSF1R) is a receptor protein-tyrosine kinase specifically expressed in monocyte-lineage cells. The article by Uesato et al. characterized the pharmacological properties of JTE-952, a novel CSF1R tyrosine kinase inhibitor. JTE-952 potently inhibited human CSF1R kinase activity and displayed no marked inhibitory activity against other kinases excluding tropomyosin-related kinase A. JTE-952 potently inhibited the CSF1-induced proliferation of human macrophages, and lipopolysaccharide-induced proinflammatory cytokine production by human macrophages and in whole blood. In addition, orally delivered JTE-952 significantly attenuated arthritis severity in a mouse model of collagen-induced arthritis. These results indicate that JTE-952 is a potentially clinically useful agent for the treatment of a variety of human inflammatory diseases, including rheumatoid arthritis.

43 巻 (2020) 2 号 p. 348-355
Curcumin Alleviates Oxaliplatin-Induced Peripheral Neuropathic Pain through Inhibiting Oxidative Stress-Mediated Activation of NF-κB and Mitigating Inflammation もっと読む

Oxaliplatin is the first-line chemotherapy for tumor treatment often accompanied with peripheral neuropathic pain. There are no specific drugs for the disease at present. Current studies have shown that curcumin has various biological activities like antioxidant, anti-inflammatory, antitumor and so on, while few studies were conducted about its role in oxaliplatin-induced peripheral neuropathic pain. The article by Zhang et al. demonstrated that curcumin could alleviate oxaliplatin-induced peripheral neuropathic pain; the mechanism might be inhibiting oxidative stress-mediated activation of NF-κB and mitigating neuroinflammation. This study will provide an experimental foundation for the clinical application of curcumin in oxaliplatin-induced neuropathic pain.

月間アクセス数ランキング 2020年01月
  • Biol. Pharm. Bull. Vol. 43 No. 2
    Current Topics: Challenges in the Control of Environmental Pathogenic Microbes
  • Biol. Pharm. Bull. Vol. 43 No. 1
    Current Topics: Recent Advances in Research on the Mechanisms and Regulation of Allergic Diseases