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Volume 27 (2012)
- Issue 5 Pages 342-
- Issue 4 Pages 246-
- Issue 3 Pages 156-
- Issue 2 Pages 76-
- Issue 1 Pages 10-
Volume 27, Issue 3
JULY
Displaying 1-6 of 6 articles from this issue
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Feature articles “Challenge for transdermal delivery of malabsorptive drugs and vaccines” Editor : Kenji Sugibayashi
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Hiroaki Todo, Kenji Sugibayashi2012 Volume 27 Issue 3 Pages 156-163
Published: July 30, 2012
Released on J-STAGE: October 30, 2012
JOURNAL FREE ACCESSSkin has been greatly paid attention as an application site for therapeutic drugs having local and systematic effects. Recently, transdermal patches were approved to treat central nervous system disorderssuch as Alzheimer's disease and attention deficit hyperactivity disorder. Furthermore, transdermal vaccine has been developed because the epidermis is a useful immune-reactive field. Drug permeation through skin, however, is commonly lower than that through other mucosals. Thus, the enhancement of transdermal permeation of drugs is necessary to expect the effect of topically applied drugs. In this chapter, we show chemical and physical enhancement strategies for transdermal drug delivery and discuss their usefulness.View full abstractDownload PDF (1282K) -
Keiichi Kawai2012 Volume 27 Issue 3 Pages 164-175
Published: July 30, 2012
Released on J-STAGE: October 30, 2012
JOURNAL FREE ACCESSThe application of skin electroporation in combination with iontophoresis (mesoporation) is a markedly effective means to deliver drugs substances into the skin.In this review, the principle of mesoporation and the results of its dermatological applications will be introduced.View full abstractDownload PDF (3564K) -
Mitsuhiro Shikida2012 Volume 27 Issue 3 Pages 176-183
Published: July 30, 2012
Released on J-STAGE: October 30, 2012
JOURNAL FREE ACCESSMicro-Electro-Mechanical Systems (MEMS) technologies have miniaturized numerous types of physical sensors, e.g., pressure, acceleration, and flow sensors, onto silicon wafers. Along with their capabilities of miniaturizing mechanical components to a size of less than a few millimeters, MEMS technologies have also been introduced to the fabrication of micro-needles for the evaluation of the nerve systems. These micro-needles also have been used as trans-dermal drug delivery systems since the late 1990s. In this article, the outline of the MEMS fabrication is summarized, and then various type micro-needles, Si-, metal-, and polymer-needles, developed by MEMS are reviewed. The micro-needle produced by a biodegradable material is finally stated as an example the most expecting technology for the trans-dermal drug delivery systems.View full abstractDownload PDF (1426K) -
Minoru Oda2012 Volume 27 Issue 3 Pages 184-193
Published: July 30, 2012
Released on J-STAGE: October 30, 2012
JOURNAL FREE ACCESSTransdermal drug delivery using Microneedle is receiving plenty of attention, not only from pharmaceutical companies but also healthcare professionals, because Microneedle would make possible transdermal drug delivery of the proteins and/or peptides.In this review, I will introduce 3M s/hMTS as representatives of microneedle and touch on future potential of these.View full abstractDownload PDF (1210K) -
Naohiro Seo, Hiroshi Shiku2012 Volume 27 Issue 3 Pages 194-201
Published: July 30, 2012
Released on J-STAGE: October 30, 2012
JOURNAL FREE ACCESSSkin is a leading candidate tissue in delivery system of peptide and protein including T-cell epitope sequence, and T-cell epitope-coding DNA because the dendritic cells which function as a powerful antigen-presenting cell for tumor- and pathogenic microorganism-specific T cell activation resides in epidermis and dermis of the skin. In this article, we describe the current topics of percutaneous vaccination for immunogenic antigen delivery.View full abstractDownload PDF (611K) -
Samir Mitragotri2012 Volume 27 Issue 3 Pages 202-212
Published: July 30, 2012
Released on J-STAGE: October 30, 2012
JOURNAL FREE ACCESSDelivering vaccines into skin offers an appealing alternative to needle-based administration for immunization. Besides the benefit of directly delivering vaccines into immunologically competent skin, cutaneous immunization provides the benefits of patient compliance and dose sparing. Vaccine delivery into skin, however, is limited by the barrier of stratum corneum, the outermost layer of skin. A variety of technologies have been developed to permeabilize the stratum corneum to enhance vaccine entry into skin. This review provides a summary of some of these technologies that are based on mechanical disruption of stratum corneum. These include liquid jet injectors, powder injectors, ultrasound, microneedles, abrasive devices, thermal ablation and lasers. An overview of the principles of these technologies, their ability to deliver vaccines and experience in clinical applications is discussed.View full abstractDownload PDF (351K)
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