The crystallographic study of macrocyclic cyclophane inclusion compounds is reviewed. Cyclophanes such as [2.2.2], [6.6.6], [3.3.3.3] and [6.1.6.1] paracyclophanes and calixarenes with intramolecular hydrophobic cavities surrounded by benzene walls incorporate neutral guest molecules to give molecular inclusion compounds (
cavitate) in solutions and in the solid state. Tri-
o-thymotide forms chiral single crystals of cage type or channel type
clathrate which have enantiomeric excess of guest molecules. [J. Cryst. Soc. Jpn.
28,
261 (1986) ] .
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