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Takeo Kobayashi, Shu-Min Wong
1988 Volume 1988 Issue Supplement23 Pages
1-4
Published: June 20, 1988
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To obtain information on so-called abnormal sensation in the throat in other countries, inquiry letters were sent to foreign institutions and responses were obtained from Korea, Mainland China, Taiwan, Singapore, India, Austria, Germany, Netherlands, France, Hungary and USA. The inquiry contain e d questions on etiology, pathogenesis, age and sex of patients, tests and treatment. In we s tern countries, this condition was most frequently called globus hystericus syndrome or globus syndrome. In Chinese traditional medicine, the term _??__??__??_ (sensation of plum seed) has been used since the Ming dynasty. In most answers, fear of cancer was stressed as a psy c hogenic etiology. In USA, abnormal contraction of the cervical smooth muscles including the masticatory muscles was thought to be a possible cause of the disorders.
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Shoji Takayasu, Sanae Katori, Kimiaki Katori, Koichi Shibui, Hisashige ...
1988 Volume 1988 Issue Supplement23 Pages
5-17
Published: June 20, 1988
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An epidemiological investigation on the pharyngolaryngeal abnormal sensation was conducted by questionnaire survey in 1137 adults selected randomly.
Of 301 persons who had the abnormal sensation,125 (41.1%) recognized it as being due to a disease and only 28 (9.2%) visited a doctor for the treatment.
From the observation we reevaluated the causal relationshi p between the psychosomatic characteristics and environmental factors of the patients with the abnormal sensation. The factors concerned directly with development of the abnormal sensation were (i) other diseases (regardless of the kind of disease), (ii) habits such as drinking and smoking and (iii) dwelling environment. As for the age, sex, physical constitution character, work place environment, tastes, drugs taken daily they are modified by other factors so as to look as if they are related closely to the syndrome.
The prognosis was significantly better in the treated group tha n in the non-treated group, thus suggesting the need of treatment.
The results of a questionnaire s u rvey among general otolaryngologists reveal that their interest in the abnormal sensation of the pharyngolaryngeal region is not necessarily high.
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Takemoto Shin, Shigeru Wada, Michiru Kawasoe, Tadatsugu Maeyama
1988 Volume 1988 Issue Supplement23 Pages
18-23
Published: June 20, 1988
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Disorders of sensory function and autonomic regulation in the larynx might result in such abnormal sensations of the larynx. In this study, we observed substance P (SP)containing sensory nerve endings and noradrenergic autonomic nerves in the laryngeal mucosa of the dog by light microscopy. SP containing sensory nerve endings were observed in intra-epithelial free nerve endings and taste bud-like structures. The intraepithelial free nerve endings were most dense on the lower surface of the vocal cord mucosa. The taste bud-like structures were classified into two types; simple terminations and reticular terminations. Both sensory SP containing and autonomic noradrenergic nerve fibers were observed around arterioles and in laryngeal glands. Disorders of fine neural control may be related to abnormal sensations of the larynx.
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Yoshikazu Yoshida, Yasumasa Tanaka, Minoru Hirano, Takeshi Kanaseki
1988 Volume 1988 Issue Supplement23 Pages
24-30
Published: June 20, 1988
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The distribution of the peripheral sensory nerve fibers of the hypopharynx in cats, was studied using WGA-HRP. The sensory innervation was only ipsilateral to the injection side. The vagal sensory nerve innervated between the level of middle of the aryepiglottic fold and the caudal end of the piriform sinus, while the glossopharynge al sensory nerve supplied the rostral part of the vagal innervation. In the laryngeal portion (mucosa covering the posterior cricoarytenoid muscle), networks and fine nerve fibers were found, and in the lateral and posterior walls, networks were noted. The density was the highest in the laryngeal portion, particularly in the lateral and posterior wall.
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Ryoto Oya, Miyuki Tanaka, Toru Matsunaga
1988 Volume 1988 Issue Supplement23 Pages
31-39
Published: June 20, 1988
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The patients with abnormal sensation in the throat were examined with respect to blood flow in the throat, contents of serum iron and plasma noradrenalin, autonomic nervous function, and depressin score.
Blood flow in the throat, studied by spectrum analysis, was significantly decreased. The value of serum iron of the patients was low and plasma noradrenalin high. Autonomic nervous function, especialy parasympathetic nerve function, was significantly reduced. Many patients had high depression scores. From these results, we considered that we have to treat the patients according to the represented causes.
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Shoko Inaki, Hiroshi Okamura, Toshihiro Mori
1988 Volume 1988 Issue Supplement23 Pages
40-45
Published: June 20, 1988
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We investigated swallowing functions in the patients with abnormal sensation in the throat. Fluoroscopic examination was done on 234 patients, and measurement of swallowing pressure on 41 patients. Fluoroscopic examination revealed marked barium coating of the pharyngeal mucosa, which indicates a hypotonic condition. In measurement of swallowing pressure, a spike-like wave at the hypopharyngeal region or a continuous high pressure wave at the upper esophageal region was often observed. Abnormal elevation of the swallowing pressure at the hypopharyngeal of esophageal region was observed in 40% of the patients. These results indicated that one of the causes of this disease is a subclinical functional or organic swallowing disorder.
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Yasuo Koike, Yasuo Ishitani, Katsuhiko Nakamura, Rieko Nakanishi
1988 Volume 1988 Issue Supplement23 Pages
46-50
Published: June 20, 1988
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A method for quantifying foreign-body sensation in the throat (FBST) is described. First,60 short sentences representing various degrees of FBST were selected from clinical histories. Fifty judges then evaluated the degree of FBST on a 10-point scale for each sentence. The mean score was regarded as the FBST value represented by the sentence concerned. Twelve sentences, each of which had a different FBST value, were chosen out of the 60 sentences, and were listed according to the magnitude of the FBST value. This list was then adopted to quantify the degree of FBST. Each patient was asked to select one or two sentences which indicate the most similar property to his or her FBST from the list; and the average of the values attached to the selected sentences was regarded as the FBST value for the patient. Some probational results based on 81 patients were presented. Usefulness of this method in detecting hypopharyngeal malignancy was shown.
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Katsuhiko Nakamura, Yasuo Ishitani, Toshiyuki Yamashita, Yasuo Koike
1988 Volume 1988 Issue Supplement23 Pages
51-54
Published: June 20, 1988
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Statistical investigation were carried out on 149 patients with foreign-body sensation in the thoat. The patients were given a minor tranquilizer (Medazepam, Mexazolam, Bromazepam) and an anti-inflammatory enzyme for screening and treatment.
The screening was designed to detect high risk patients. We evaluated the efficacy of the screening using evaluation score.
All 11 patients who had a tumor such as hypopharyngeal cancer, nasopharyngeal tumor, thyroid adenoma showed not improvement in score after treatment. This means there was no false negative cases in the screening.
There were 98 patients who had a in f lammatory disease or no evidence of disease.
Forty-eight patients (49%) showed improvement in their scores after trea t m ent. The most effective tranquilizer was Bromazepam (70.8%), followed by Mexasolam (43.3%) and Medasepam (40.9%).
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Kazuo Suzaki, Yoshihiko Terayama, Katsuhiko Tanaka
1988 Volume 1988 Issue Supplement23 Pages
55-61
Published: June 20, 1988
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We employed the barium clearance test and a video disk recording system for the functional diagnosis on the patients having abnormal sensation at the throat. The barium clearance test revealed a significant difference between patients with (n=482)and without abnormal sensation (n=1271).
Video recording revealed elon g ated barium transit time in the pharyngeal stage in 71% of the patients having “stenosisfeel”.
There was no evidence of f unctional disorder in 23% of the patients having abnormal sensation at the throat. The present examination was easy to perform in a short time.
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Hirotaka Ito, Shunkichi Baba
1988 Volume 1988 Issue Supplement23 Pages
62-65
Published: June 20, 1988
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The pharynx, larynx and cervical esophagus are topographic targets for many kinds of diseases organic or psychogenic, and are complained of a variety of subjective symptoms by patients. We developed a method in which the patient swallows a small silicon tube (4.5 5.5mm in diameter), into which the laryngofiberscope is inserted to make observation of the esophageal inside. The method and appliance as well as the results of observation are presented here.
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Toshio Ogoshi, Meri Kato, Keiko Horii, Yoshio Takagi, Yoko Takeyasu, N ...
1988 Volume 1988 Issue Supplement23 Pages
66-71
Published: June 20, 1988
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In 80 cases of abnormal sensation in the throat, ventiratory function was examined by spirometry and flow-volume curves.
The patients with normal flow-volume curves were subjected to respiratory hypersensitivity tests using an asthograph with inhalation of methacholine. There were divided into three groups, i. e.,38 cases with asthmatic patterns,34 cases with bronchitic patterns, and 8 cases who reacted positively in the methacholine challenge tests with asthograph.
Six ty-eight patients were initially treated with some drugs. Lysozyme chloride and minor tranquilizer were used for many cases in all three groups. Secondary treatment was done in 35 cases in which the initial treatment was not effective.
The efficacy rates of lysozyme chloride and minor tranquilizer were over 70%in the bronchitic pattern group and the mthacholine challenge positive group, but slightly less than 40% in the asthmatic pattern group.
On the other hand, antiallergic drugs and bronchodilators were very effective in the asthmatic pattern group.
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Eiichi Ishiyama, Akinori Kida, Otohiko Takayama, Katsumi Kojima
1988 Volume 1988 Issue Supplement23 Pages
72-78
Published: June 20, 1988
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Abnormal sensations of the pharyngo-larynx was analyzed by nine psychological tests between May 1st and October 30,1984 and the patients were followed up for two years. Nine chart questionnaires of the psychological tests were found to be high reliable for the evaluation.
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Mikikazu Yamagiwa, Yasuo Sakakura
1988 Volume 1988 Issue Supplement23 Pages
79-84
Published: June 20, 1988
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We investigated the causative factors in abnormal sensation in the throat (AST)with special attention to the inflammatory changes of the upper respiratory tract. Local anesthetic (4% Xylocaine®) applied topically on the pharyngeal mucosa reduced abnormal sensations in 80% of patients with AST. The result indicated that AST mainly originates in the pharyngolaryngeal region.
The patients with AST had repeated l y recurring sore throat and or common cold symptoms with a significantly higher incidence than controls. Pharyngeal inflammatory changes were observed more commonly in patients with AST than in controls. A double-blind test revealed that the combined use of an anti-inflammatory agent with minor tranquilizer is significantly more effective than single use of minor tranquilizer.
Therefore, we conclude that there is a close relationship between AST and pharyngolaryngeal inflammation.
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Takashi Matsunaga, Kazuhiro Ohta, Noriko Kashiwagi
1988 Volume 1988 Issue Supplement23 Pages
85-92
Published: June 20, 1988
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Mucosal inflammation in the pharynx and larynx was investigated in 50 patients with the lump sensation in the throat (lump sensation group) and 20 patients without the throat symptom (control group). The incidence of mucosal inflammation in the pharynx was 74%,52% in the larynx of the lump sensation group. It was more than that of the control group.
Mucosal in flammation in the pharynx and larynx were classified into local type, diffuse type and normal type. Eighteen cases were diffuse type,24 cases local type and 5 cases normal type in the lump sensation group. Blood examination was almost normal in the lump sensation group. Bacteriological study of oropharynx revealed that the incidence of Haemophilus was relatively high in the lump sensation group. Histological study on lateral pharyngeal lymphatic band indicated that inflammation of the mucosa was higher in the diffuse type in the lump sensation group. The relation between the local changes and symptoms was investigated by observing the clinical course. Symptoms improved with the improvement of local findings in most patients with diffuse type, but not in most patients with local type.
We speculated that the lump sensation in the throat was caused by the mucosal inflammation, particularly, in patients with diffuse type.
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Toshikazu Tokuda, Tadao Nishimura, Mikio Yagisawa, Haruhiko Nakamura, ...
1988 Volume 1988 Issue Supplement23 Pages
93-97
Published: June 20, 1988
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We examined the relationship of pre/ and post (6 months) /operative abnormal pharyngolaryngeal sensation with sex, age and tonsillar findings in patients who had undergone. A total of 73 patients included 38 aged from 4 to 9 years,16 aged from 10 to 19 years and 19 aged from 20 to 40 years. There were 48 males and 25 females.
Preoperative questioning confirmed abnormal sensation in 17 (23.3%) p a tients. No sexual difference in abnormal sensation was observed. Examination of abnormal sensation in relation to the degree of tonsillar hypertrophy revealed more complaints with a greater degree of hypertrophy from patients aged from 4 to 19 years, but no definite relationship between both these symptoms in patients aged over 20 years.
No relationship was observed between abnormal sensation and either swelling of pharyngeal lateral fold, tonsillar pus plug or dry mouth sensation. A close relationship was seen between abnormal sensation and redness of arcus palatinus anterior. Improvement in abnormal sensation was seen in 16 patients.
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Fumihiko Ohta, Hiroko Yonekawa
1988 Volume 1988 Issue Supplement23 Pages
98-103
Published: June 20, 1988
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Causal factor and protracted factor are suspected to cause long-standing abnormal sensation in the throat. Observation were performed before laryngo-microsurgery, immediately after surgery,3-6 weeks after operation and by "enquete" inquiry. Laryngeal diseases were considered as a causal factor. Abnormal sensation due to laryngeal polyp disappeared soon after surgery, though the sensation continued for several weeks after surgery for Reinke's edema. Laryngeal microsurgery was a causal factor. Abnormal sensation due to laryngo-microsurgery occurred more often in females, and the sensation soon subsided off. Smoking was considered as a causal factor, but not as a delayed factor. Abnormal CMI score was not a delayed factor.
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Masakatsu Toda, Yasuo Kitano, Fumihiko Ohta
1988 Volume 1988 Issue Supplement23 Pages
104-109
Published: June 20, 1988
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A statistical investigation was carried out on 1008 cases of thyroid disorders and 1540 cases of foreign-body sensation in the throat (foreign-body sensation). There were 112 men and 896 women in the thyroid disorder group,596 men and 944 women in the foreign-body sensation group. Most of patients in both groups were between 30 and 50 years old. Our findings strongly suggest that there are much relationship of thyroid disorders (especially chronic thyroiditis) and foreigh-body sensation, and that conbination therapy of anti-inflammatory enzyme, minor tranquillizer and thy-. roid hormon (T4) is more effective in patients with chronic thyroiditis than only antiinflammatory enzyme and minor tranquillizer.
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Noriyuki Yanagita, Kazuya Ishida, Kiyotaka Asami
1988 Volume 1988 Issue Supplement23 Pages
110-115
Published: June 20, 1988
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We analyzed the serum Fe in 367 patients (136 male,231 female; group I) who had abnormal sensation in the throat, without organic disease between January 1984and December 1986. Serum Fe values in 44 patients (group II) with sudden deafness were used as controls. Twelve patients showed very low serum Fe levels. Three patients were suspected of having Plummer-Vinson syndrome. All patients who exhibited low serum Fe and high UIBC levels were placed on a drug regimen containing Fe preparation for a period of six months. Following this, the complaints of these patients improved dramatically. Serum Fe levels were below normal limits in 28.9%of the males and 26.8% of the females in group I, compared with 50% of the males and 34.7% of the females in group II. There was no significant difference between the two groups. Therefore, we concluded that the serum Fe level is not related to abnormal sensation in the throat.
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Shigeru Furuta, Ichiro Moriyama, Masaru Ohyama
1988 Volume 1988 Issue Supplement23 Pages
116-122
Published: June 20, 1988
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The premenopausal and postmenopausal women with abnormal sensation in the throat were analyzed clinically. The patients with the abnormal sensation in the throat had climacteric syndrome. They complained mainly of the sensation of contracting in the throat and had cardiovascular symptoms, such as perspiration, hotflushes, palpitation and shortness of breath. The analysis of Kupperman's index, applied to a set of 17 climacteric symptoms, was useful for the diagnosis of abnormal sensation in the throat resulting from climacteric pathogenesis.
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Tadatsugu Maeyama, Takemoto Shin, Hiroshi Watanabe, Michiru Kawasoe
1988 Volume 1988 Issue Supplement23 Pages
123-128
Published: June 20, 1988
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Sixteen patients underwent surgery for abnormal sensations in the pharyngolaryngeal region. Between October,1981 and September,1987, we operated on seven cases of vallecular cyst, two cases of laryngeal granuloma and one case each of laryngeal papilloma, hypertrophy of the lingual tonsil, hypertrophy of the lingual mucosa, tongue ulcer, elongated uvula, elongated styloid process and cyst of the arytenoid region. Complaints disappeared after surgery for the organic lesions in 15 patients. However, complaints reappeared in three cases with recurrence of lesions which later disappeared after re-operation. Our surgery suggest that surgery is effective for some patients with abnormal sensations in the pharyngolaryngeal region.
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Akinori Kida, Eiichi Ishiyama, Otohiko Takayama
1988 Volume 1988 Issue Supplement23 Pages
129-134
Published: June 20, 1988
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Ninety-eight patients with abnormal sensation of the pharyngolarynx underwent psychological tests, such as (CMI), (SQR-D), and (Y-G). These patients had higher incidences of the sensation III and IV regions of CMI than did normal controls. SQRD diagnosed 24.5% of them to be slightly depressive or on the borderline. Those who were reported to be abnormal by CMI or SQR-D tended to be resistant to treatment despite adequate counselling; however, they did respond to tranquilizer (Cercine)or antipsychotic agent (Lexotan) therapy.
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Mizuyo Hori, Isao Takimoto, Hiromichi Ishigami, Shigeru Inafuku, Kazum ...
1988 Volume 1988 Issue Supplement23 Pages
135-143
Published: June 20, 1988
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We studied 39 patients (35 male,4 female) who were admitted because of cancer of the pharynx (26 cases), larynx (3 cases), and esophagus (10 cases) excluding cancer of epipharynx. As m ore than a half (26 patients) suffered from laryngeal cancer, hoarseness was the most frequent chief complaint, seen in 25 cases. Eleven patients complained of pharyngolaryngeal discomfort. One case of esophageal cancer took about one year to diagnose from the first visit to clinic. Among patients with laryngeal or mesopharyngeal cancer, there were some cases that only complained of the pharyngolaryngeal discomfort.
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Hideo Tanaka, Kazusige Fujikawa, Hiroyuki Mukoudaka, Michihiko Nozue
1988 Volume 1988 Issue Supplement23 Pages
144-148
Published: June 20, 1988
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We reported five cases of Plummer Vinson Syndrome (P-V Syndrome), and compared them with cases of abnormal sensation of pharynx and larynx. Patients of P-V Syndrome mostly complained of pain in swallowing. Therefore, they came to the hospital relatively early. The grade of anemia was higher in P-V Syndrome than in cases of other iron deficit anemia. The improvement of anemia did not always coi n cide with that of subjective symptoms. P-V Syndrome cases showed higher improvement of subjective symptoms by treatment.
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Jun Kawakubo, Kazuaki Okikura, Yoshiko Aika
1988 Volume 1988 Issue Supplement23 Pages
149-157
Published: June 20, 1988
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We histological observed the esophageal mucous membrane in 30 cases of the lumps in the throat by 3 methods; radiological classification of the deglutition, esophageal fiberscopy, and endoscopic biopsy. We found 5 cases of the esoph a gitis by fiberscopy: 1 of candidiasis,2 of esophagitis,1 of penphygus, and 1 of burn scar. There were no obvious endoscopical inflammation in the remaining 25 cases. In 25 cases, we analyzed in the relation between the histopathologic change and deglutition. Hyperplasia of the squamous epithel was seen in 9 cases, all were caused by abnormal hypertonic deglutition. Slight cxsudation in the basal layer was found in 8 cases, and the exsudation was considered to be related to the appearence of dysesthesia.
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Shinobu Iwamura
1988 Volume 1988 Issue Supplement23 Pages
158-164
Published: June 20, 1988
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Foreign body sensation and/or stenotic feeling in the pharyngolaryngeal structure of the patients can be one of symptomatology in cases with spastic dysphonia; A 39-year-old woman suffered from the above described symptom for several years, which appeared whenever she attempted to speak. Her vocal pitch during medical interview for history-taking appeared lower and sounded to be squeezing with an intermittent stoppage of her natural speech while normal vocal sound became apparent when laughing and/or raising her vocal pitches. The pharyngolaryngeal structure and their functions were normal on the basis of a mirror examination as well as a fiberoptic measurement, except that the supraglottic space was narrowed on phonation which prevented visualization of the full length of the true vocal cords and also that both the false and the true vocal cords intermittently motioned in spasmodic fashion, thus providing spasmodic phonatory pattern or stacatto in her voice.
These characteristic laryngeal findings as well as spasmodic vocal pattern, how ever, disappeared promptly on elevation of her modal pitch or after injection of 1% procaine (3 ml) around the unilateral recurrent laryngeal nerve in the neck. Laryngeal tomographic investigations delineated approaimation of the bilateral false vocal cords on phonation confirming a hyperfunctional state of the vocal sturucture.
Electromyographic studies of the larynx revealed grouped discharge mixed with normal action potentials in the thyroarytenoid muscle fibers on phonation with lower pitch sound. These grouped EGM signals, however, disappeared again quickly on raising her vocal modal picth.
Selective division of a thyroarytenoid branch of the right recurrent laryngeal nerve was performed and resulted in normal voice and no stenotic sensation in the pharynx.
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Atsuko Nishikawa, Hiroyuki Kitamura, Shohaku Oyagi, Kensuke Nose, Shin ...
1988 Volume 1988 Issue Supplement23 Pages
165-168
Published: June 20, 1988
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A rare case of a right non-recurrent nerve was encountered during the thyroid lobectomy of a 53-year-old woman. The nerve passed directly and transversely from the vagus never to the larynx. An abberant right subclavian artery was found by X ray study. The existence of such a case suggests that we should expose the recurrent nerve in thyroid surgery.
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Atsuko Nishikawa, Hiroyuki Kitamura, Shohaku Oyagi, Kensuke Nose, Shin ...
1988 Volume 1988 Issue Supplement23 Pages
169-172
Published: June 20, 1988
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Akira Miyoshi
1988 Volume 1988 Issue Supplement23 Pages
173-177
Published: June 20, 1988
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Sandplay therapy was attempted in a 6 year-old girl with abnormal pharyngeal and laryngeal sensation. Local inflam m ation was assumed to have triggered the abnormal sensation. The initial irritation was complicated by the pre-existing psychosomatic conflict, which stemed from the lack of communication within the family, and in particular, with her father. Sandplay therapy appeared to be effective in this condition. The therapy was useful in the formation of rapport, and to elucidate the psychological construct of the child reflected on the sandplay. Finally, it facilitated catharsis of the stress factor that was the psychogenic basis of the disease process.
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Yutaka Isogai
1988 Volume 1988 Issue Supplement23 Pages
178-182
Published: June 20, 1988
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Six cases of lump sensation with an elongated styloid were conservatively treated with eperizone hydrochloride (Myonal '), a muscle relaxant for muscle tension syndrome. Eperizone hydrochloride was effective in all 6 cases.
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