Japanese Journal of Hospital Pharmacy
Online ISSN : 2185-9477
Print ISSN : 0389-9098
ISSN-L : 0389-9098
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Volume 13, Issue 2
Displaying 1-2 of 2 articles from this issue
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  • Evaluation of 3-Cyanopropyltrichlorosilane Treated Thin Layer Chromatographic Plate
    Application of Analysis for Typical Steroids in Ointment
    MASAYOSHI OHTA, MITSUYOSHI OKAMOTO, AKIYOSHI FUTAMURA, SHIGEO GOTOH, S ...
    1987 Volume 13 Issue 2 Pages 111-115
    Published: April 01, 1987
    Released on J-STAGE: August 11, 2011
    DOIhttps://doi.org/10.5649/jjphcs1975.13.111
    JOURNAL FREE ACCESS
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    Typical steroids in ointment were studied by thin layer chromatography (TLC) using a cyanopropyl-chemically bonded stationary phase, prepared from pre-coated silica gel plate treated with toluene solution containing 3-cyanopropyltrichlorosilane (CN). TLC plate with CN was applied to the evaluation of typical steroids in ointment samples. The CN treated plate was developed in a chromatographic chamber at room temperature with chloroformmethanol (95: 5 v/v) to a distance of 8cm from the origin.
    After drying, the plate was sprayed with 10% sulfuric acid solution, and heated. Steroid spots on the chromatogram were measured with a TLC densitometer equipped with a dual-wave length TLC scanner at λEX 380nm, λEM 550nm.
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  • Dissolution Behavior of Nifedipine Sustained-release Preparations
    KAZUYUKI UENO, KIYOTAKA UEMOTO, HIROSHI SHINOHARA, TSUNEHISA SEKIYAMA
    1987 Volume 13 Issue 2 Pages 116-119
    Published: April 01, 1987
    Released on J-STAGE: August 11, 2011
    DOIhttps://doi.org/10.5649/jjphcs1975.13.116
    JOURNAL FREE ACCESS
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    Dissolution behavior of 2 kinds (A and B) of Nifedipine (NF) sustained-release preparations were investigated. Dissolution rates were measured by the J. P. X dissolution test procedure in pH 1.2, 3.0, 4.0, 5.0, and 6.8 solutions, which contained various amounts of Tween 80.
    The following results were obtained: The release from the sample A was pH-independent, but was much effected by wet. The addition of 0.125% of Tween 80 to the solution caused 50% increase of the release from the sample A. The sample B showed pH-dependent release, and was found to be composed of 40% of rapid-release granules and 60% of enteric and sustained-release one.
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