Japanese Journal of Clinical Immunology
Online ISSN : 1349-7413
Print ISSN : 0911-4300
ISSN-L : 0911-4300
Volume 26, Issue 1
Displaying 1-4 of 4 articles from this issue
  • [in Japanese]
    2003 Volume 26 Issue 1 Pages 1-8
    Published: February 28, 2003
    Released on J-STAGE: February 13, 2009
    JOURNAL FREE ACCESS
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  • [in Japanese], [in Japanese], [in Japanese]
    2003 Volume 26 Issue 1 Pages 9-20
    Published: February 28, 2003
    Released on J-STAGE: February 13, 2009
    JOURNAL FREE ACCESS
    Download PDF (2679K)
  • Toru Hiyoshi, Nobuo Hisano, Fumito Akasu, Michiyasu Yoshitsugu, Tamiko ...
    2003 Volume 26 Issue 1 Pages 21-27
    Published: February 28, 2003
    Released on J-STAGE: February 13, 2009
    JOURNAL FREE ACCESS
    The patient is a 71-year-old woman who underwent splenectomy after the diagnosis of idiopathic portal hypertension (IPH) at the age of 51 years. Thirst and polyuria occurred in December 1995. In April 1996, she was hospitalized for assessment because of elevation of her blood glucose and HbA1C levels to 535mg/dl and 14.9%, respectively. The GAD antibody level was high (256 units/ml) and tests for ICA and anti-TPO antibody were positive. Since her HLA type was A 24, B 13, B 46, CW 1, CW 3, DRB 1*[0901/0901], DQB 1*[0303/0303], and DPB 1*[0201/0201], this patient was regarded as being susceptible to type 1 diabetes mellitus. There was no evidence of portal hypertension at the time of consultation.
    Although there was a considerable difference in the time of onset between IPH and type I diabetes mellitus, we reported this patient as a valuable case for investigating the complications of autoimmune disease.
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  • Yuki Nanke, Shigeru Kotake, Masako Hara, Naoyuki Kamatani
    2003 Volume 26 Issue 1 Pages 28-33
    Published: February 28, 2003
    Released on J-STAGE: February 13, 2009
    JOURNAL FREE ACCESS
    A 43-year-old woman was diagnosed with pulmonary hypertension (PH) associated with systemic sclerosis (SSc). On admission, absence of both thromboembolism and severe interstitial lung disease suggested that vascular damage led to PH. In addition, the patient met the criteria for the classification of SLE. Methylprednisolone pulse therapy was effective not only for the clinical symptoms but also the laboratory findings. The report of overlap syndrome associated with PH is rare. The prognosis of patients with collagen diseases associated PH has been reported to be extremely poor. Since PH in this case responded favorably to methylprednisolone pulse therapy, this therapy may be effective for PH associated with overlap syndrome.
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