Advances in Animal Cardiology

Show abstractHide abstract

We evaluated the effect of ozagrel and darteparin after mitral valve repair under cardiopulmonary bypass in dogs. A total of 32 dogs were included in this study (9.7±2.3 years old, 5.3±3.7 kg). The two out of 32 cases were excluded because of death with aspiration or hypotension within 24 hours after surgery. Dogs (n=14) were treated with hydrochloric acid ozagrel orally (p.o.) for a dose of 5 or 10 mg/kg BID, or Low molecular weight heparin; dalteparin (5 IU/kg/hr) after the operation. The dose of dalteparin was increased gradually (until 50 or 75 IU/kg/hr), and then changed to subcutaneous injection of 50–100 IU/kg/day for 6–12 days (n=16). After that, ozagrel hydrochloride (10 mg/kg p.o., BID), a thoromboxane A 2 synthase inhibitor, was administered for 1 month instead of dalteparin. In this study, it was suggested there were less thrombosis in the darteparin-treated group. The number of platelets increased earlier in darteparin-treated group. Also, there was significant lower rate of hyperlipasemia in the darteparin-treated group. This study has shown the effect of darteparin in preventing adverse events, and it was emphasized the importance of anticoagulation management after mitral valve repair.

View full abstract

Download PDF (323K)

A 3-year-old male Tibetan spaniel weighing 5.8 kg was presented with severe cardiac murmur. A grade V and III/VI systolic murmur was auscultated, loudest at the left cardiac base and the right cardiac apex, respectively. Echocardiography revealed severe pulmonic stenosis (pressure gradient 104 mmHg), and membranous ventricular septal defect (6 mm diameter), and mild aortic regurgitation. Using extracorporeal circulation, cardiotomy was performed, the septal defect was closed by direct mattress suture and the valvular stenosis was corrected by valvulotomy and patch-graft technique. Three months after surgery, pulmonic stenosis was improved (pressure gradient 53 mmHg), and shunting flow and aortic regurgitation was disappeared. This case was considered that successful correction of pulmonic stenosis with ventricular septal defect by cardiotomy using cardiopulmonary bypass.

View full abstract

Register with J-STAGE for free!