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Volume 38 (2005)
- Issue 2 Pages 47-
- Issue 1 Pages 1-
Predecessor
Volume 38, Issue 1
Displaying 1-4 of 4 articles from this issue
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ORIGINALS
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Noriko IMAOKA, Noboru MACHIDA, Tatsuo KANESIGE, Hirosi ITOU2005 Volume 38 Issue 1 Pages 1-8
Published: 2005
Released on J-STAGE: March 03, 2006
JOURNAL FREE ACCESS -
—Interaction with Ketoconazole—Kentaro ANDO, Satoshi UNAKAMI, Mayumi OBO, Atsushi SASAKI, Yumi MAKITA ...2005 Volume 38 Issue 1 Pages 9-20
Published: 2005
Released on J-STAGE: March 03, 2006
JOURNAL FREE ACCESSThe present study examined whether the effects of terfenadine administered via the clinical route on the electrocardiographic QT interval could be captured in an animal experiment using cynomolgus monkeys. Further, we also investigated any possible effect on hERG (human ether-a-go-go-related gene) potassium current at the plasma concentration when terfenadine caused QT interval prolongation. No effects were found on the corrected QT interval (QTc) in the monkeys when terfenadine alone was administered at 10 to 100 mg/kg. When pretreated with ketoconazole (100 mg/kg), a CYP3A4 inhibitor, terfenadine was administered at the pharmacologically effective dose of 30 mg/kg prolonged QTc. The Cmax value of terfenadine at this time was 26.1 ng/mL (about 50 nmol/L). hERG potassium currents were significantly blocked at 1 nmol/L, corresponding to 2% of terfenadine at 50 nmol/L. From the results that terfenadine prolonged QTc in cynomolgus monkeys when administered via the clinical route with pretreatment with ketoconazole and that 1 nmol/L blocked hERG potassium current, it is suggested that the present in vivo and in vitro methods may be useful in predicting QT prolongation effects in humans.View full abstractDownload PDF (393K) -
Takayuki MURAKAMI, Kazuyuki UCHIDA, Mitsuyoshi HAGIO, Katsumi HAMANA2005 Volume 38 Issue 1 Pages 21-26
Published: 2005
Released on J-STAGE: March 03, 2006
JOURNAL FREE ACCESSAtrioventricular septal defects were observed in 5 of 687 (0.73%) bovine hearts with congenital cardiovascular anomalies. All of these 5 hearts had no connecting tongue of valve tissue joining together the anterior and posterior bridging cusps and showed the complete form of the atrioventricular septal defects with a common atrioventricular orifice. In each of these hearts the anterior bridging cusp extended from the left ventricle across the interventricular septum to the right ventricle. Each anterior bridging cusp was not attached to the interventricular septum and was free floating over the septum, moreover the right ventricular portion of this cusp inserted to the great papillary muscle of the right ventricle by the chordae tendineae (Rastelli, type C).View full abstractDownload PDF (850K) -
Yasutomo HORI, Noboru OGI, Takashi EBISAWA, Shigeki YAMANO, Masami UEC ...2005 Volume 38 Issue 1 Pages 27-33
Published: 2005
Released on J-STAGE: March 03, 2006
JOURNAL FREE ACCESSThis study aimed to evaluate clinical sign of digoxin toxicosis in chronic heart failure dogs administered digoxin. Fourteen dogs with digoxin toxicosis were evaluated in terms of there body temperature, the weight, digestive organ symptom, change of kidney function before digoxin prescription and during appearance of toxicosis. The clinical signs of digoxine toxicosis increased with serum digoxin concentration≥2.0 ng/ml. The body temperature decreased at digoxin intoxication significantly. Creatinine and BUN rose in proportion to increase of serum digoxin level, and digestive symptom (anorexia, vomiting and comparison of diarrhea) developed. These results suggest that the evaluation of body temperature, change of body weight, digestive symptom, renal function (creatinine and BUN) as well as the measurement of serum digoxin level may be useful for diagnosis of the severity in digoxin intoxication and one of a guideline of informed consent for a side effect.View full abstractDownload PDF (516K)
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