Advances in Animal Cardiology
Online ISSN : 1883-5260
Print ISSN : 0910-6537
ISSN-L : 0910-6537
Current issue
Showing 1-3 articles out of 3 articles from the selected issue
  • Yasutomo HORI, Noriko ISAYAMA, Junko HARAGUCHI, Yohei YAMASHITA, Keiic ...
    2021 Volume 54 Issue 1 Pages 15-25
    Published: 2021
    Released: September 18, 2021

    Cardiac biomarkers are elevated in dogs with heart diseases including mitral valve disease (MVD). However, the difference in the regulation of atrial natriuretic peptide (ANP), N-terminal proANP (NT-proANP), N-terminal proB-type natriuretic peptide (NT-proBNP), and cardiac troponin-I (cTnI) in dogs with MVD has not been studied. We investigated plasma NT-proANP levels by MVD severity, and compared their clinical utility for assessing MVD severity. Clinically healthy dogs and client-owned dogs with MVD were examined. The diseased dogs were divided into three groups based on the American College of Veterinary Internal Medicine guidelines. Concentrations of plasma ANP, NT-proANP, NT-proBNP, and cTnI were analyzed by a commercial laboratory. Plasma ANP and NT-proANP concentrations increased significantly in stage B2 and C compared with that in the controls. They also increased significantly in stage C compared with that in stage B1. Plasma NT-proBNP and cTnI concentrations increased significantly in stage C compared with that in the controls and stage B1. Plasma NT-proANP concentration showed a strong positive correlation with ANP and NT-proBNP, and a weak positive correlation with E wave velocity, left atrial-to-aortic diameter ratio (LA/Ao raito), the left ventricular end-diastolic internal diameter corrected for body weight (LVIDDN), and VHS. The areas under the receiver-operating characteristic curve of NT-proANP used to identify dogs with each stage of MVD were comparable for other biomarkers. Circulating NT-proANP increase from the early stages of MVD, and it may be useful for assessing asymptomatic MVD. It can support echocardiographic data, but cannot be used alone to diagnose MVD.

    Download PDF (508K)