A 54-year-old male who was prescribed Sitagliptin for diabetes mellitus, and thereafter developed widespread erythema and itching 72 days after starting the treatment. He was admitted to our hospital, and therapy with oral prednisolone was commenced, but his symptoms were not resolved. We suspected that his condition was a drug eruption caused by Sitagliptin, and discontinued the drug. His skin lesions resolved promptly. Although the drug-induced lymphocyte stimulation test and patch test were both negative, oral provocation test of the drug was positive. We therefore diagnosed the patient to have a maculopapular type drug eruption caused by Sitagliptin. 167 cases of skin tissue and subcutaneous tissue disorders have been reported based on postmarketing surveillance regarding Sitagliptin, wherein among these, 2 cases showed serious side effects of Stevens-Johnson syndrome. We herein report that as far as we have been able to research at the current phase, there have not been many reports in the form of research papers regarding the occurrence of any drug induced rash associated with Sitagliptin, except for these 3 cases among both domestic and international reports.Skin Research, 11: 160-164, 2012

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A 76-year-old man presented with systemic erythema and high fever. Ten hours before the onset of the symptom, he was examined by cystography computed tomography using the nonionic iodocontrast media, iohexol because of the pancreatic cyst. Two days later, he developed small pustules on his back, abdomen and axilla. Histopathology of a biopsy specimen taken from a back showed subcorneal pustules. According to the skin test and drug-induced lymphocyte stimulation test (DLST), he was diagnosed as acute generalized exanthematous pustulosis (AGEP) induced by iohexol. AGEP induced by nonionic iodocontrast media was rare, but we need to recognize nonionic iodocontrast media is one of the cause of AGEP. And in our case, there is a possibility that preceding upper respiratory infection and anti-SSA antibody were with positive did some kind of contribution for the onset of the AGEP.Skin Research, 11: 165-169, 2012

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A 77-years-old woman presented with a 4-year history of nodules on the sole. Physical examination revealed two black nodules, 10×8mm in size and 3mm in diameter on the left sole. Dermoscopic features showed blue-whitish veil, suggestive of malignant melanoma. Biopsy specimen from the sole revealed basal cell carcinoma (BCC) histopathologically, and we resected both nodules. BCCs occur rarely on the sole. We reported our case with review of literature and speculation about the origin of plantar BCC.Skin Research, 11: 170-172, 2012

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A 53-years-old man presented with asymptomatic brownish plaques of the trunk since 7 years before. He was suffering from lasting fever, lymphadenopathy, nausea, diarrhea and dizziness. A skin biopsy showed nodular infiltrates of plasma cells in the dermis. A lymph node biopsy revealed marked plasma cells beneath the capsule. Laboratory examinations indicated polyclonal hypergammaglobulinemia, whereas C-reactive protein was elevated slightly and IL-6 was 3.4pg/ml. The diagnosis of systemic plasmacytosis was made. Although the treatment with betamethasone 6mg/day was not sufficient, these symptoms were improved after the addition of mizoribine 300mg/day.Skin Research, 11: 173-178, 2012

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