We investigated 29 evaluable cases who received concurrent chemotherapy with low dose carboplatin and radiotherapy among 99 cases diagnosed with head and neck cancer at our institute in the 2 years and 5 months prior to December 1993.
Approximately 90% had advanced cancer, and all cases involved squamous cell carcinoma (SCC) except for one case involving adenocarcinoma that metastasized from the lung.
Among 28 cases of SCC which could be assessed by TNM classification, 17 of 25 lesions (68%) showed clinical or pathological CR as determined by tumor volume (T).
CR occurred in one T
1 (100% of evaluable cases), seven T
2 (70%), three T
3 (60%) and six T
4 (67%) cases.
In consideration of the lymphnodes (N), 15 for 20 cases (75%) showed CR, including three N
1 (100%) and twelve N
2 (100%) cases. Five N
3 cases showed no response. From these results, we conclude that it is possible to expectacure of the lesion and functional preservation, even in such advenced cancer using combined therapy alone, if case selection is carefully performed.
抄録全体を表示