Journal of Oleo Science
Online ISSN : 1347-3352
Print ISSN : 1345-8957
ISSN-L : 1345-8957
Symposium on the Chemistry of Terpenes, Essential Oils and Aromatics (TEAC)
Collagen Synthesis-Promoting Effects of Andiroba Oil and its Limonoid Constituents in Normal Human Dermal Fibroblasts
Toshio MorikawaAkifumi NagatomoKayako KitazawaOsamu MuraokaTakashi KikuchiTakeshi YamadaReiko TanakaKiyofumi Ninomiya
ジャーナル フリー

2018 年 67 巻 10 号 p. 1271-1277


The seed oil of andiroba (Carapa guianensis, Meliaceae) was found to promote collagen synthesis in normal human dermal fibroblasts. To characterize the active constituents of this oil, the collagen synthesis-promoting activities of 10 principal limonoid constituents, gedunin (1), 6α-acetoxygedunin (2), 7-deacetoxy-7-oxogedunin (3), 7-deacetoxy-7α-hydroxygedunin (4), andirolide H (5), 6α-hydroxygedunin (6), methyl angolensate (7), 17β-hydroxyazadiradione (8), and carapanosides C (9) and R (10), were examined. Among them, 1–4, 6, 7, and 9 were found to significantly promote collagen synthesis without cytotoxicity at the effective concentrations.

© 2018 by Japan Oil Chemists' Society
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